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FABP2 fatty acid binding protein 2 [ Homo sapiens (human) ]

Gene ID: 2169, updated on 4-Jan-2025

Summary

Official Symbol
FABP2provided by HGNC
Official Full Name
fatty acid binding protein 2provided by HGNC
Primary source
HGNC:HGNC:3556
See related
Ensembl:ENSG00000145384 MIM:134640; AllianceGenome:HGNC:3556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FABPI; I-FABP
Summary
The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and proliferation. This protein binds saturated long-chain fatty acids with high affinity, and may act as a lipid sensor to maintain energy homeostasis. [provided by RefSeq, Aug 2017]
Expression
Biased expression in small intestine (RPKM 287.0), duodenum (RPKM 142.3) and 1 other tissue See more
Orthologs
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Genomic context

See FABP2 in Genome Data Viewer
Location:
4q26
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (119317250..119322138, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (122622352..122627246, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (120238405..120243293, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:120133934-120134507 Neighboring gene ubiquitin specific peptidase 53 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21855 Neighboring gene allregulin Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:120263717-120264310 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:120268597-120269585 Neighboring gene kelch like family member 2 pseudogene 1 Neighboring gene RNA, U4 small nuclear 33, pseudogene Neighboring gene uncharacterized LOC107986193 Neighboring gene glycerol kinase 6 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC133132

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in fatty acid metabolic process  
involved_in fatty acid transport  
involved_in intestinal lipid absorption PubMed 
involved_in long-chain fatty acid transport  
Component Evidence Code Pubs
located_in apical cortex  
is_active_in cytosol  
located_in cytosol  
located_in microvillus  
is_active_in nucleus  

General protein information

Preferred Names
fatty acid-binding protein, intestinal
Names
fatty acid binding protein 2, intestinal
intestinal-type fatty acid-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011444.1 RefSeqGene

    Range
    5024..9912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000134.4NP_000125.2  fatty acid-binding protein, intestinal

    See identical proteins and their annotated locations for NP_000125.2

    Status: REVIEWED

    Source sequence(s)
    AK025079, BC069466, BC111791
    Consensus CDS
    CCDS3712.1
    UniProtKB/Swiss-Prot
    P12104, Q2NKJ1
    Related
    ENSP00000274024.3, ENST00000274024.4
    Conserved Domains (1) summary
    pfam00061
    Location:6132
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    119317250..119322138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    122622352..122627246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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