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Trim47 tripartite motif-containing 47 [ Mus musculus (house mouse) ]

Gene ID: 217333, updated on 30-Apr-2024

Summary

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Official Symbol
Trim47provided by MGI
Official Full Name
tripartite motif-containing 47provided by MGI
Primary source
MGI:MGI:1917374
See related
Ensembl:ENSMUSG00000020773 AllianceGenome:MGI:1917374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2210023F24Rik
Summary
Enables ubiquitin-protein transferase activity. Involved in protein ubiquitination. Predicted to be located in cytosol. Is expressed in aorta and genitourinary system. Orthologous to human TRIM47 (tripartite motif containing 47). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 32.5), ovary adult (RPKM 32.0) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Trim47 in Genome Data Viewer
Location:
11 E2; 11 80.91 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115996576..116001061, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116105750..116110235, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene unc-13 homolog D Neighboring gene STARR-positive B cell enhancer ABC_E10732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115939592-115939779 Neighboring gene STARR-positive B cell enhancer ABC_E381 Neighboring gene WW domain binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E8471 Neighboring gene STARR-seq mESC enhancer starr_31193 Neighboring gene tripartite motif-containing 65 Neighboring gene STARR-positive B cell enhancer ABC_E4017 Neighboring gene mitochondrial ribosomal protein L38

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2. Qian Y, et al. Signal Transduct Target Ther, 2022 May 6. PMID 35513381, Free PMC Article
  2. Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia. Tang J, et al. J Exp Med, 2020 Apr 6. PMID 31999304, Free PMC Article
  3. Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina. Balasubramanian R, et al. Gene Expr Patterns, 2014 Jan. PMID 24333658, Free PMC Article
  4. The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Ji YX, et al. Nat Med, 2018 Feb. PMID 29291351
  5. Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development. Yamamoto H, et al. Cell Rep, 2020 Jan 21. PMID 31968244

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2.
    Title: TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM47
Names
tripartite motif protein 47
tripartite motif-containing protein 47
NP_001192010.1
NP_766158.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205081.1 → NP_001192010.1  E3 ubiquitin-protein ligase TRIM47 isoform 1

    See identical proteins and their annotated locations for NP_001192010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL607108, BC145059, BG065693
    Consensus CDS
    CCDS56823.1
    UniProtKB/TrEMBL
    Q497Z1
    Related
    ENSMUSP00000021120.6, ENSMUST00000021120.6
    Conserved Domains (3) summary
    cd00162
    Location:9 → 61
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:182 → 221
    zf-B_box; B-box zinc finger
    cd15808
    Location:425 → 630
    SPRY_PRY_TRIM47; PRY/SPRY domain in tripartite motif-containing protein 47 (TRIM47), also known as RING finger protein 100 (RNF100) or Gene overexpressed in astrocytoma protein (GOA)

  2. NM_172570.5 → NP_766158.3  E3 ubiquitin-protein ligase TRIM47 isoform 2

    See identical proteins and their annotated locations for NP_766158.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL607108, BC100317, BG065693
    Consensus CDS
    CCDS56822.1
    UniProtKB/Swiss-Prot
    A2A862, Q6P249, Q811J7, Q8BVZ8, Q8C0E3, Q8R1K0, Q8R3Y1
    UniProtKB/TrEMBL
    Q497Z1
    Related
    ENSMUSP00000102049.2, ENSMUST00000106441.8
    Conserved Domains (3) summary
    cd00162
    Location:9 → 61
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam00643
    Location:182 → 221
    zf-B_box; B-box zinc finger
    cd15808
    Location:424 → 629
    SPRY_PRY_TRIM47; PRY/SPRY domain in tripartite motif-containing protein 47 (TRIM47), also known as RING finger protein 100 (RNF100) or Gene overexpressed in astrocytoma protein (GOA)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115996576..116001061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0E3.2 GenPept UniProtKB/Swiss-Prot:Q8C0E3

Gene LinkOut

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