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Lin52 lin-52 DREAM MuvB core complex component [ Mus musculus (house mouse) ]

Gene ID: 217708, updated on 30-Apr-2024

Summary

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Official Symbol
Lin52provided by MGI
Official Full Name
lin-52 DREAM MuvB core complex componentprovided by MGI
Primary source
MGI:MGI:3045391
See related
Ensembl:ENSMUSG00000085793 AllianceGenome:MGI:3045391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830457H20Rik
Summary
Predicted to be involved in transcription, DNA-templated. Predicted to be part of DRM complex. Orthologous to human LIN52 (lin-52 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 5.3), cerebellum adult (RPKM 4.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Lin52 in Genome Data Viewer
Location:
12 D1; 12 39.22 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84497965..84593293)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84451508..84531533)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8493 Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2 Neighboring gene aldehyde dehydrogenase family 6, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E80 Neighboring gene STARR-seq mESC enhancer starr_32738 Neighboring gene STARR-seq mESC enhancer starr_32740 Neighboring gene STARR-seq mESC enhancer starr_32741 Neighboring gene visual system homeobox 2 Neighboring gene STARR-seq mESC enhancer starr_32746 Neighboring gene ATP-binding cassette, sub-family D member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  2. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
  3. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DRM complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
protein lin-52 homolog
Names
lin-52 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405332.1 → NP_001392261.1  protein lin-52 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110564, AC120402
    Related
    ENSMUSP00000152849.2, ENSMUST00000221033.2

  2. NM_001405333.1 → NP_001392262.1  protein lin-52 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC110564, AC120402

  3. NM_001405334.1 → NP_001392263.1  protein lin-52 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC110564, AC120402
    UniProtKB/TrEMBL
    A0A8Q0Q6C4

  4. NM_001405335.1 → NP_001392264.1  protein lin-52 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC110564, AC120402

  5. NM_001405336.1 → NP_001392265.1  protein lin-52 homolog isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC110564, AC120402

  6. NM_001405337.1 → NP_001392266.1  protein lin-52 homolog isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC110564, AC120402

  7. NM_173756.5 → NP_776117.2  protein lin-52 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC110564, AC120402
    Consensus CDS
    CCDS49110.1
    UniProtKB/TrEMBL
    A0A8Q0Q6C4
    Related
    ENSMUSP00000133045.3, ENSMUST00000137170.4
    Conserved Domains (1) summary
    pfam10044
    Location:14 → 107
    LIN52; Retinal tissue protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84497965..84593293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157328.1 → XP_036013221.1  protein lin-52 homolog isoform X4

    Conserved Domains (1) summary
    pfam10044
    Location:18 → 98
    LIN52; Retinal tissue protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CD94.1 GenPept UniProtKB/Swiss-Prot:Q8CD94

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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