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Utp4 UTP4 small subunit processome component [ Mus musculus (house mouse) ]

Gene ID: 21771, updated on 30-Apr-2024

Summary

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Official Symbol
Utp4provided by MGI
Official Full Name
UTP4 small subunit processome componentprovided by MGI
Primary source
MGI:MGI:1096573
See related
Ensembl:ENSMUSG00000041438 AllianceGenome:MGI:1096573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Naic; Cirh1a; Cirhin; Tex292; Teg-292
Summary
Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and regulation of transcription, DNA-templated. Predicted to act upstream of or within rRNA processing. Predicted to be located in chromosome and fibrillar center. Predicted to be part of 90S preribosome; small-subunit processome; and t-UTP complex. Is expressed in peripheral nervous system ganglion; renal cortex; telencephalon ventricular layer; and thymus primordium. Human ortholog(s) of this gene implicated in cholestasis and primary biliary cholangitis. Orthologous to human UTP4 (UTP4 small subunit processome component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 18.0), liver E14 (RPKM 17.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 53.32 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107620272..107649726)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106893640..106923094)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22582 Neighboring gene predicted gene, 53451 Neighboring gene hyaluronan synthase 3 Neighboring gene ES cell cis-regulatory motif 8a Neighboring gene CTF8, chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein Neighboring gene STARR-seq mESC enhancer starr_22583 Neighboring gene ribosomal protein L10, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_22588 Neighboring gene syntrophin, basic 2 Neighboring gene STARR-seq mESC enhancer starr_22589 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:109526496-109526679 Neighboring gene predicted gene, 22085

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. López-Fernández LA, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464256
  2. Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. López-Fernández LA, et al. Mamm Genome, 1996 Sep. PMID 8703127
  3. A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis. Chagnon P, et al. Am J Hum Genet, 2002 Dec. PMID 12417987, Free PMC Article
  4. Development of an efficient screening system to identify novel bone metabolism-related genes using the exchangeable gene trap mutagenesis mouse models. Kurogi S, et al. Sci Rep, 2017 Jan 20. PMID 28106071, Free PMC Article
  5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in maturation of SSU-rRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of t-UTP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of t-UTP complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U3 small nucleolar RNA-associated protein 4 homolog
Names
cirrhosis, autosomal recessive 1A
testis-expressed gene 292 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358982.1 → NP_001345911.1  U3 small nucleolar RNA-associated protein 4 homolog

    Status: VALIDATED

    Source sequence(s)
    AC123864
    Consensus CDS
    CCDS52664.1
    UniProtKB/Swiss-Prot
    Q62306, Q62307, Q69Z48, Q6NVG9, Q8R2N2, Q8VEL5
    UniProtKB/TrEMBL
    Q3UJY3
    Conserved Domains (2) summary
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:16 → 306
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_011574.2 → NP_035704.2  U3 small nucleolar RNA-associated protein 4 homolog

    See identical proteins and their annotated locations for NP_035704.2

    Status: VALIDATED

    Source sequence(s)
    BC068113, CN718589, DV658234
    Consensus CDS
    CCDS52664.1
    UniProtKB/Swiss-Prot
    Q62306, Q62307, Q69Z48, Q6NVG9, Q8R2N2, Q8VEL5
    UniProtKB/TrEMBL
    Q3UJY3
    Related
    ENSMUSP00000048377.6, ENSMUST00000047629.7
    Conserved Domains (2) summary
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:16 → 306
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    107620272..107649726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2N2.3 GenPept UniProtKB/Swiss-Prot:Q8R2N2

Gene LinkOut

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