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Tfg Trk-fused gene [ Mus musculus (house mouse) ]

Gene ID: 21787, updated on 14-May-2024

Summary

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Official Symbol
Tfgprovided by MGI
Official Full Name
Trk-fused geneprovided by MGI
Primary source
MGI:MGI:1338041
See related
Ensembl:ENSMUSG00000022757 AllianceGenome:MGI:1338041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables identical protein binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum exit site. Is expressed in several structures, including branchial arch; limb; nasal process; and nervous system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 57. Orthologous to human TFG (trafficking from ER to golgi regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 162.5), small intestine adult (RPKM 131.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C1.1; 16 34.22 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (56510692..56541801, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (56690329..56717467, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41064 Neighboring gene discs, large homolog-associated protein 5 pseudogene Neighboring gene ABI family member 3 binding protein Neighboring gene STARR-seq mESC enhancer starr_41065 Neighboring gene STARR-seq mESC enhancer starr_41066 Neighboring gene STARR-seq mESC enhancer starr_41067 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:56717659-56717768 Neighboring gene STARR-seq mESC enhancer starr_41068 Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene predicted gene 15693 Neighboring gene transmembrane protein 45a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells. Steinmetz TD, et al. Autophagy, 2021 Sep. PMID 32910713, Free PMC Article
  2. Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity. Yamamotoya T, et al. Sci Rep, 2017 Oct 12. PMID 29026155, Free PMC Article
  3. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure. Beetz C, et al. Proc Natl Acad Sci U S A, 2013 Mar 26. PMID 23479643, Free PMC Article
  4. Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases. Yamamotoya T, et al. Sci Rep, 2022 Feb 4. PMID 35121777, Free PMC Article
  5. Characterization of TFG in mus musculus and Caenorhabditis elegans. Mencinger M, et al. Biochem Biophys Res Commun, 1999 Apr 2. PMID 10092511

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells.
    Title: TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells.
  2. TFG in pancreatic beta-cells plays a vital role in maintaining both the mass and function of beta-cells, and its dysfunction increases the tendency to develop glucose intolerance.
    Title: Trk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.
  3. Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.
    Title: Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein TFG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252443.1 → NP_001239372.1  protein TFG isoform 2

    See identical proteins and their annotated locations for NP_001239372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    CT025158
    UniProtKB/TrEMBL
    Q8C2C6, Q9D828
    Conserved Domains (1) summary
    cd06401
    Location:11 → 89
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

  2. NM_001357124.1 → NP_001344053.1  protein TFG isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT025158
    Conserved Domains (1) summary
    cd06401
    Location:11 → 91
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

  3. NM_001357125.1 → NP_001344054.1  protein TFG isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT025158
    UniProtKB/TrEMBL
    Q9D828
    Conserved Domains (2) summary
    cd06401
    Location:11 → 91
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    cl28271
    Location:291 → 393
    dnaA; chromosomal replication initiation protein; Provisional

  4. NM_001357126.1 → NP_001344055.1  protein TFG isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT025158
    Conserved Domains (1) summary
    cd06401
    Location:11 → 91
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...

  5. NM_019678.3 → NP_062652.1  protein TFG isoform 1

    See identical proteins and their annotated locations for NP_062652.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AK158539, BB783895, BB856666, BY061830
    Consensus CDS
    CCDS28224.1
    UniProtKB/TrEMBL
    Q9D828, Q9Z1A1
    Related
    ENSMUSP00000067867.8, ENSMUST00000065515.14
    Conserved Domains (2) summary
    cd06401
    Location:11 → 91
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    PRK14086
    Location:295 → 397
    dnaA; chromosomal replication initiator protein DnaA

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    56510692..56541801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521980.4 → XP_006522043.1  protein TFG isoform X1

    See identical proteins and their annotated locations for XP_006522043.1

    UniProtKB/TrEMBL
    Q9D828, Q9Z1A1
    Conserved Domains (2) summary
    cd06401
    Location:11 → 91
    PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
    PRK14086
    Location:295 → 397
    dnaA; chromosomal replication initiator protein DnaA
Nucleotide Protein Strain
Heading Accession and Version

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