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Zfp322a zinc finger protein 322A [ Mus musculus (house mouse) ]

Gene ID: 218100, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp322aprovided by MGI
Official Full Name
zinc finger protein 322Aprovided by MGI
Primary source
MGI:MGI:2442566
See related
Ensembl:ENSMUSG00000046351 AllianceGenome:MGI:2442566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf322; Znf322a
Summary
Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of stem cell population maintenance and regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in central nervous system; early conceptus; genitourinary system; retina; and trunk somite. Orthologous to human ZNF322 (zinc finger protein 322). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 6.1), CNS E14 (RPKM 5.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp322a in Genome Data Viewer
Location:
13 A3.1; 13 9.55 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23537273..23553378, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23353103..23369208, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930557F10 gene Neighboring gene RIKEN cDNA 4930586N03 gene Neighboring gene nuclear encoded tRNA isoleucine 9 (anticodon AAT) Neighboring gene nuclear encoded tRNA methionine 12 (anticodon CAT) Neighboring gene STARR-seq mESC enhancer starr_33930 Neighboring gene STARR-seq mESC enhancer starr_33932 Neighboring gene STARR-positive B cell enhancer mm9_chr13:23460983-23461284 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene nuclear encoded tRNA isoleucine 3 (anticodon AAT)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency. Ma H, et al. PLoS Genet, 2014 Feb. PMID 24550733, Free PMC Article
  2. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • RP23-9O13.9, 9630054P07Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of stem cell population maintenance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 322

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111107.2 → NP_001104577.1  zinc finger protein 322

    See identical proteins and their annotated locations for NP_001104577.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK036302, AL669819, CF743666
    Consensus CDS
    CCDS26337.1
    UniProtKB/Swiss-Prot
    Q8BZ89, Q8K0A0, Q91W42
    UniProtKB/TrEMBL
    Q3TDD5
    Conserved Domains (3) summary
    COG5048
    Location:79 → 229
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:179 → 203
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001286155.1 → NP_001273084.1  zinc finger protein 322

    See identical proteins and their annotated locations for NP_001273084.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK036302, AL669819, CF743666
    Consensus CDS
    CCDS26337.1
    UniProtKB/Swiss-Prot
    Q8BZ89, Q8K0A0, Q91W42
    UniProtKB/TrEMBL
    Q3TDD5
    Conserved Domains (3) summary
    COG5048
    Location:79 → 229
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:179 → 203
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001286156.1 → NP_001273085.1  zinc finger protein 322

    See identical proteins and their annotated locations for NP_001273085.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK036302, AL669819, CF743666
    Consensus CDS
    CCDS26337.1
    UniProtKB/Swiss-Prot
    Q8BZ89, Q8K0A0, Q91W42
    UniProtKB/TrEMBL
    Q3TDD5
    Conserved Domains (3) summary
    COG5048
    Location:79 → 229
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:179 → 203
    zf-H2C2_2; Zinc-finger double domain

  4. NM_172586.4 → NP_766174.1  zinc finger protein 322

    See identical proteins and their annotated locations for NP_766174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 3. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK036302, AL669819
    Consensus CDS
    CCDS26337.1
    UniProtKB/Swiss-Prot
    Q8BZ89, Q8K0A0, Q91W42
    UniProtKB/TrEMBL
    Q3TDD5
    Related
    ENSMUSP00000061524.3, ENSMUST00000050101.9
    Conserved Domains (3) summary
    COG5048
    Location:79 → 229
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:179 → 203
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23537273..23553378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZ89.1 GenPept UniProtKB/Swiss-Prot:Q8BZ89

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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