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Skic3 SKI3 subunit of superkiller complex [ Mus musculus (house mouse) ]

Gene ID: 218343, updated on 21-May-2024

Summary

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Official Symbol
Skic3provided by MGI
Official Full Name
SKI3 subunit of superkiller complexprovided by MGI
Primary source
MGI:MGI:2679923
See related
Ensembl:ENSMUSG00000033991 AllianceGenome:MGI:2679923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ski3; Ttc37
Summary
Predicted to be involved in nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'. Predicted to be located in cytosol; nucleoplasm; and transcriptionally active chromatin. Predicted to be part of Ski complex. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 1. Orthologous to human TTC37 (tetratricopeptide repeat domain 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 4.4), CNS E11.5 (RPKM 3.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Skic3 in Genome Data Viewer
Location:
13 C1; 13 40.95 cM
Exon count:
50
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (76246837..76338437)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (76098705..76190318)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41006 Neighboring gene predicted gene, 31161 Neighboring gene arylsulfatase K Neighboring gene STARR-positive B cell enhancer ABC_E8536 Neighboring gene STARR-positive B cell enhancer ABC_E2413 Neighboring gene STARR-seq mESC enhancer starr_35057 Neighboring gene STARR-seq mESC enhancer starr_35058 Neighboring gene family with sequence similarity 81, member B Neighboring gene predicted gene, 31219 Neighboring gene predicted gene, 31516

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition. Akagi K, et al. Genome Res, 2008 Jun. PMID 18381897, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • KIAA0372

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in RNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ski complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ski complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
superkiller complex protein 3
Names
SKI3 subunit of superkiller complex protein
tetratricopeptide repeat domain 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081352.3 → NP_001074821.1  superkiller complex protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001074821.1

    Status: VALIDATED

    Source sequence(s)
    AC122242, CT010470
    Consensus CDS
    CCDS36735.1
    UniProtKB/Swiss-Prot
    F8VPK0
    Related
    ENSMUSP00000153521.2, ENSMUST00000224386.2
    Conserved Domains (3) summary
    TIGR02917
    Location:2 → 673
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:530 → 555
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:566 → 592
    TPR; TPR repeat [structural motif]

  2. NM_001426640.1 → NP_001413569.1  superkiller complex protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122242, CT010470
    UniProtKB/Swiss-Prot
    F8VPK0

  3. NM_001426641.1 → NP_001413570.1  superkiller complex protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122242, CT010470
    UniProtKB/Swiss-Prot
    F8VPK0

  4. NM_001426642.1 → NP_001413571.1  superkiller complex protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122242, CT010470

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    76246837..76338437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517233.4 → XP_006517296.1  superkiller complex protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006517296.1

    UniProtKB/Swiss-Prot
    F8VPK0
    Related
    ENSMUSP00000089045.4, ENSMUST00000091466.4
    Conserved Domains (3) summary
    TIGR02917
    Location:2 → 673
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:530 → 555
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:566 → 592
    TPR; TPR repeat [structural motif]

  2. XM_036158010.1 → XP_036013903.1  superkiller complex protein 3 isoform X3

    Conserved Domains (3) summary
    TIGR02917
    Location:93 → 493
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:350 → 375
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:386 → 412
    TPR; TPR repeat [structural motif]

  3. XM_036158009.1 → XP_036013902.1  superkiller complex protein 3 isoform X3

    Conserved Domains (3) summary
    TIGR02917
    Location:93 → 493
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:350 → 375
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:386 → 412
    TPR; TPR repeat [structural motif]

  4. XM_006517236.5 → XP_006517299.1  superkiller complex protein 3 isoform X4

    Conserved Domains (3) summary
    TIGR02917
    Location:2 → 673
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:530 → 555
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:566 → 592
    TPR; TPR repeat [structural motif]

  5. XM_036158007.1 → XP_036013900.1  superkiller complex protein 3 isoform X1

    UniProtKB/Swiss-Prot
    F8VPK0
    Conserved Domains (3) summary
    TIGR02917
    Location:2 → 673
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:530 → 555
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:566 → 592
    TPR; TPR repeat [structural motif]

  6. XM_036158008.1 → XP_036013901.1  superkiller complex protein 3 isoform X1

    UniProtKB/Swiss-Prot
    F8VPK0
    Conserved Domains (3) summary
    TIGR02917
    Location:2 → 673
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:530 → 555
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:566 → 592
    TPR; TPR repeat [structural motif]

  7. XM_006517234.3 → XP_006517297.1  superkiller complex protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006517297.1

    UniProtKB/Swiss-Prot
    F8VPK0
    Conserved Domains (3) summary
    TIGR02917
    Location:2 → 673
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:530 → 555
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:566 → 592
    TPR; TPR repeat [structural motif]

  8. XM_006517235.3 → XP_006517298.1  superkiller complex protein 3 isoform X2

    Conserved Domains (3) summary
    TIGR02917
    Location:225 → 625
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:482 → 507
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:518 → 544
    TPR; TPR repeat [structural motif]

RNA

  1. XR_001780777.3 RNA Sequence

  2. XR_382438.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F8VPK0.1 GenPept UniProtKB/Swiss-Prot:F8VPK0

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