Trpc6 transient receptor potential cation channel, subfamily C, member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpc6provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily C, member 6provided by MGI
Primary source: MGI:MGI:109523
See related: Ensembl:ENSMUSG00000031997 AllianceGenome:MGI:109523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRP-6; Trrp6; mtrp6; LLHWJM002; LLHWJM003; LLHWJM004
Summary: Enables store-operated calcium channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Located in plasma membrane and slit diaphragm. Is expressed in several structures, including gut; limb; liver; nervous system; and reproductive system. Used to study focal segmental glomerulosclerosis 2. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 2.0), frontal lobe adult (RPKM 1.1) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A1; 9 2.46 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (8543868..8680753)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (8543867..8680752)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPV4 Channels Promote Pathological, but Not Physiological, Cardiac Remodeling through the Activation of Calcineurin/NFAT and TRPC6.
Title: TRPV4 Channels Promote Pathological, but Not Physiological, Cardiac Remodeling through the Activation of Calcineurin/NFAT and TRPC6.
TRPC6 Deletion Enhances eNOS Expression and Reduces LPS-Induced Acute Lung Injury.
Title: TRPC6 Deletion Enhances eNOS Expression and Reduces LPS-Induced Acute Lung Injury.
Trpc6 knockout protects against renal fibrosis by restraining the CN-NFAT2 signaling pathway in T2DM mice.
Title: Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice.
Low-Level Photobiomodulation Therapy Modulates H2O2 Production, TRPC-6, and PGC-1alpha Levels in the Dystrophic Muscle.
Title: Low-Level Photobiomodulation Therapy Modulates H(2)O(2) Production, TRPC-6, and PGC-1α Levels in the Dystrophic Muscle.
Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.
Title: Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.
Trpc6 knockout improves behavioral dysfunction and reduces Abeta production by inhibiting CN-NFAT1 signaling in T2DM mice.
Title: Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice.
Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling.
Title: Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling.
New Positive TRPC6 Modulator Penetrates Blood-Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice.
Title: New Positive TRPC6 Modulator Penetrates Blood-Brain Barrier, Eliminates Synaptic Deficiency and Restores Memory Deficit in 5xFAD Mice.
Myocardial TRPC6-mediated Zn(2+) influx induces beneficial positive inotropy through beta-adrenoceptors.
Title: Myocardial TRPC6-mediated Zn(2+) influx induces beneficial positive inotropy through β-adrenoceptors.
Stimulation of the EP3 receptor causes lung oedema by activation of TRPC6 in pulmonary endothelial cells.
Title: Stimulation of the EP(3) receptor causes lung oedema by activation of TRPC6 in pulmonary endothelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (128)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpc6 (e-PCR), detects polymorphism
- UniSTS:531243

Trrp6 (e-PCR), detects polymorphism
- UniSTS:144687

px-50g7 (e-PCR)
- UniSTS:257891

U49069 (e-PCR)
- UniSTS:159849

Trpc6 (e-PCR), detects polymorphism
- UniSTS:516717

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actinin binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in single fertilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in slit diaphragm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: short transient receptor potential channel 6

Names: calcium entry channel; transient receptor protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282086.2 → NP_001269015.1 short transient receptor potential channel 6 isoform 2

See identical proteins and their annotated locations for NP_001269015.1

Status: VALIDATED

Source sequence(s)

AC155906, AC156791

Consensus CDS

CCDS90494.1

UniProtKB/TrEMBL

Q3UZG1

Related

ENSMUSP00000149686.2, ENSMUST00000214596.2

Conserved Domains (4) summary

cd00204
Location:104 → 238

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:81 → 818

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:252 → 311

TRP_2; Transient receptor ion channel II

sd00045
Location:131 → 158

ANK; ANK repeat [structural motif]
NM_001282087.2 → NP_001269016.1 short transient receptor potential channel 6 isoform 3

See identical proteins and their annotated locations for NP_001269016.1

Status: VALIDATED

Source sequence(s)

AC155906

Consensus CDS

CCDS90495.1

UniProtKB/TrEMBL

Q6NV56

Related

ENSMUSP00000150193.2, ENSMUST00000217462.2

Conserved Domains (5) summary

cd00204
Location:104 → 238

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08344
Location:252 → 311

TRP_2; Transient receptor ion channel II

pfam12796
Location:136 → 244

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:103 → 152

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:131 → 158

ANK; ANK repeat [structural motif]
NM_001429123.1 → NP_001416052.1 short transient receptor potential channel 6 isoform 1

Status: VALIDATED

Source sequence(s)

AC155906, AC156791
NM_001429124.1 → NP_001416053.1 short transient receptor potential channel 6 isoform 4

Status: VALIDATED

Source sequence(s)

AC155906, AC156791
NM_001429125.1 → NP_001416054.1 short transient receptor potential channel 6 isoform 5

Status: VALIDATED

Source sequence(s)

AC155906, AC156791
NM_001429126.1 → NP_001416055.1 short transient receptor potential channel 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC155906, AC156791
NM_013838.3 → NP_038866.2 short transient receptor potential channel 6 isoform 1

See identical proteins and their annotated locations for NP_038866.2

Status: VALIDATED

Source sequence(s)

AC155906, AC156791

Consensus CDS

CCDS22815.1

UniProtKB/Swiss-Prot

B9EIW2, Q61143, Q9Z2J1

Related

ENSMUSP00000057965.7, ENSMUST00000050433.8

Conserved Domains (2) summary

TIGR00870
Location:81 → 896

trp; transient-receptor-potential calcium channel protein

sd00045
Location:131 → 158

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

8543868..8680753

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242360.4 → XP_011240662.2 short transient receptor potential channel 6 isoform X4

Conserved Domains (2) summary

TIGR00870
Location:131 → 868

trp; transient-receptor-potential calcium channel protein

sd00045
Location:181 → 208

ANK; ANK repeat [structural motif]
XM_006509850.4 → XP_006509913.1 short transient receptor potential channel 6 isoform X1

See identical proteins and their annotated locations for XP_006509913.1

UniProtKB/Swiss-Prot

B9EIW2, Q61143, Q9Z2J1

Conserved Domains (2) summary

TIGR00870
Location:81 → 896

trp; transient-receptor-potential calcium channel protein

sd00045
Location:131 → 158

ANK; ANK repeat [structural motif]
XM_011242359.3 → XP_011240661.1 short transient receptor potential channel 6 isoform X2

Conserved Domains (2) summary

TIGR00870
Location:81 → 868

trp; transient-receptor-potential calcium channel protein

sd00045
Location:131 → 158

ANK; ANK repeat [structural motif]
XM_006509849.4 → XP_006509912.1 short transient receptor potential channel 6 isoform X3

Conserved Domains (2) summary

TIGR00870
Location:100 → 915

trp; transient-receptor-potential calcium channel protein

sd00045
Location:150 → 177

ANK; ANK repeat [structural motif]