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FGF1 fibroblast growth factor 1 [ Homo sapiens (human) ]

Gene ID: 2246, updated on 11-Apr-2024

Summary

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Official Symbol
FGF1provided by HGNC
Official Full Name
fibroblast growth factor 1provided by HGNC
Primary source
HGNC:HGNC:3665
See related
Ensembl:ENSG00000113578 MIM:131220; AllianceGenome:HGNC:3665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AFGF; ECGF; FGFA; ECGFA; ECGFB; FGF-1; HBGF1; HBGF-1; GLIO703; ECGF-beta; FGF-alpha
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Expression
Biased expression in brain (RPKM 36.0), kidney (RPKM 21.0) and 4 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
5q31.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (142592178..142698070, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (143123428..143229306, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141971743..142077635, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141711019-141711518 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:141721844-141723043 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141734625-141735426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141735427-141736228 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16471 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:141740409-141740647 Neighboring gene Sharpr-MPRA regulatory region 738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141743173-141743894 Neighboring gene SPRY4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23319 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:141768171-141768672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:141771555-141772234 Neighboring gene Sharpr-MPRA regulatory region 12170 Neighboring gene Sharpr-MPRA regulatory region 9292 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:141854065-141854633 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:141854634-141855201 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:141855756-141856266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:141902675-141903176 Neighboring gene VISTA enhancer hs1640 Neighboring gene ribosomal protein S12 pseudogene 10 Neighboring gene FGF1 promoter D Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:142024170-142025369 Neighboring gene FGF1 promoter C Neighboring gene Sharpr-MPRA regulatory region 3450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142039508-142040008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142040009-142040509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142047003-142047511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142047512-142048019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142049247-142049746 Neighboring gene NANOG hESC enhancer GRCh37_chr5:142052360-142052880 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:142064129-142064998 Neighboring gene FGF1 promoter B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16473 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142150581-142151416 Neighboring gene long intergenic non-protein coding RNA 1844 Neighboring gene NANOG hESC enhancer GRCh37_chr5:142176991-142177492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16477 Neighboring gene Rho GTPase activating protein 26 Neighboring gene ARHGAP26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142242364-142242980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142242981-142243597 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142243598-142244214 Neighboring gene Sharpr-MPRA regulatory region 7053

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells. Lampart A, et al. Cells, 2022 Feb 2. PMID 35159330, Free PMC Article
  2. FGF Exhibits an Important Biological Role on Regulating Cell Proliferation of Breast Cancer When it Transports Into The Cell Nuclei. Gao Y, et al. Cell Biochem Biophys, 2022 Jun. PMID 34796419
  3. Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding. Govind Kumar V, et al. J Phys Chem B, 2021 Nov 25. PMID 34762427
  4. Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor. Agrawal S, et al. Sci Rep, 2021 Aug 2. PMID 34341408, Free PMC Article
  5. Expression and function of fibroblast growth factor 1 in the hypertrophied ligamentum flavum of lumbar spinal stenosis. Habibi H, et al. J Orthop Sci, 2022 Mar. PMID 33637374

See all (257) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The optimized priming effect of FGF-1 and FGF-2 enhances preadipocyte lineage commitment in human adipose-derived mesenchymal stem cells.
    Title: The optimized priming effect of FGF-1 and FGF-2 enhances preadipocyte lineage commitment in human adipose-derived mesenchymal stem cells.
  2. Intracellular FGF1 protects cells from apoptosis through direct interaction with p53.
    Title: Intracellular FGF1 protects cells from apoptosis through direct interaction with p53.
  3. FGF1 reduces cartilage injury in osteoarthritis via regulating AMPK/Nrf2 pathway.
    Title: FGF1 reduces cartilage injury in osteoarthritis via regulating AMPK/Nrf2 pathway.
  4. MiR-143-3p Increases the Radiosensitivity of Breast Cancer Cells Through FGF1.
    Title: MiR-143-3p Increases the Radiosensitivity of Breast Cancer Cells Through FGF1.
  5. FGF Exhibits an Important Biological Role on Regulating Cell Proliferation of Breast Cancer When it Transports Into The Cell Nuclei.
    Title: FGF Exhibits an Important Biological Role on Regulating Cell Proliferation of Breast Cancer When it Transports Into The Cell Nuclei.
  6. Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells.
    Title: Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells.
  7. Expression and function of fibroblast growth factor 1 in the hypertrophied ligamentum flavum of lumbar spinal stenosis.
    Title: Expression and function of fibroblast growth factor 1 in the hypertrophied ligamentum flavum of lumbar spinal stenosis.
  8. Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding.
    Title: Mechanistic Picture for Monomeric Human Fibroblast Growth Factor 1 Stabilization by Heparin Binding.
  9. Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos.
    Title: Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos.
  10. Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor.
    Title: Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor.
Submit: New GeneRIF Correction See all GeneRIFs (148)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neurotoxic effects are inhibited by the presence of fibroblast growth factor 1 (FGF1) PubMed
Tat tat HIV-1 Tat induces the expression and secretion of FGF-1 from primary murine embryonic fibroblasts, an effect that may be relevant to the pathophysiological development of AIDS associated Kaposi's sarcoma PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables S100 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables integrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of protein kinase B activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in anatomical structure morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in branch elongation involved in ureteric bud branching IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mesonephric epithelium development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organ induction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of hepatocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of endothelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fibroblast growth factor 1
Names
beta-endothelial cell growth factor
endothelial cell growth factor, alpha
endothelial cell growth factor, beta
fibroblast growth factor 1 (acidic)
heparin-binding growth factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000800.5 → NP_000791.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000791.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the full-length isoform (1). Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DA189432
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Related
    ENSP00000338548.2, ENST00000337706.7
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  2. NM_001144892.3 → NP_001138364.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001138364.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, BC032697
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Related
    ENSP00000352329.6, ENST00000359370.10
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  3. NM_001144934.2 → NP_001138406.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001138406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DA649213
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Related
    ENSP00000404742.2, ENST00000441680.6
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  4. NM_001144935.2 → NP_001138407.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001138407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DA389088, DC344309
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Related
    ENSP00000396195.2, ENST00000419524.6
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  5. NM_001257205.1 → NP_001244134.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001244134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DC344309, DQ655917
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Related
    ENSP00000480791.1, ENST00000621536.4
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  6. NM_001257206.2 → NP_001244135.1  fibroblast growth factor 1 isoform 4

    See identical proteins and their annotated locations for NP_001244135.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 8, 13, 14, 21 and 22 encode isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC005370, AI283639, AK289762, DC344309
    UniProtKB/TrEMBL
    A8K147
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 147
    FGF; Fibroblast growth factor

  7. NM_001257207.2 → NP_001244136.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001244136.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, AK312301
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Related
    ENSP00000479024.1, ENST00000612258.4
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  8. NM_001257208.2 → NP_001244137.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001244137.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DB220987
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Related
    ENSP00000367285.1, ENST00000378046.5
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  9. NM_001257209.1 → NP_001244138.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001244138.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DA111414, DB220987
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Related
    ENSP00000480980.1, ENST00000619447.4
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  10. NM_001257210.2 → NP_001244139.1  fibroblast growth factor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001244139.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1, 4-7, 9-12, and 15-20 encode the same isoform (1).
    Source sequence(s)
    AC005370, AI283639, DA660034
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Related
    ENSP00000481868.1, ENST00000610990.4
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  11. NM_001257211.2 → NP_001244140.1  fibroblast growth factor 1 isoform 4

    See identical proteins and their annotated locations for NP_001244140.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 8, 13, 14, 21 and 22 encode isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC005370, AI283639, DA388578, DB220987
    UniProtKB/TrEMBL
    A8K147
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 147
    FGF; Fibroblast growth factor

  12. NM_001257212.2 → NP_001244141.1  fibroblast growth factor 1 isoform 4

    See identical proteins and their annotated locations for NP_001244141.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 8, 13, 14, 21 and 22 encode isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC005370, AI283639, DA575048
    UniProtKB/TrEMBL
    A8K147
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 147
    FGF; Fibroblast growth factor

  13. NM_001354951.2 → NP_001341880.1  fibroblast growth factor 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 1, 4-7, 9-12, and 16-20, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  14. NM_001354952.2 → NP_001341881.1  fibroblast growth factor 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 1, 4-7, 9-12, 15, and 17-20, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  15. NM_001354953.2 → NP_001341882.1  fibroblast growth factor 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 1, 4-7, 9-12, 15, 16 and 18-20, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  16. NM_001354954.2 → NP_001341883.1  fibroblast growth factor 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 1, 4-7, 9-12, 15-17, 19, and 20, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  17. NM_001354955.2 → NP_001341884.1  fibroblast growth factor 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 1, 4-7, 9-12, 15-18, and 20, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  18. NM_001354956.2 → NP_001341885.1  fibroblast growth factor 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 1, 4-7, 9-12, and 15-19, encodes isoform 1.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4275.1
    UniProtKB/Swiss-Prot
    B2R5T0, D3DQF2, P05230, P07502, Q16588
    UniProtKB/TrEMBL
    A0A7U3JVZ2
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 148
    FGF; Fibroblast growth factor

  19. NM_001354957.2 → NP_001341886.1  fibroblast growth factor 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 8, 13, 14, and 22, encodes isoform 4.
    Source sequence(s)
    AC005370, AC005592
    UniProtKB/TrEMBL
    A8K147
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 147
    FGF; Fibroblast growth factor

  20. NM_001354958.2 → NP_001341887.1  fibroblast growth factor 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22), as well as variants 8, 13, 14, and 21, encodes isoform 4.
    Source sequence(s)
    AC005370, AC005592
    UniProtKB/TrEMBL
    A8K147
    Conserved Domains (1) summary
    pfam00167
    Location:25 → 147
    FGF; Fibroblast growth factor

  21. NM_001354959.2 → NP_001341888.1  fibroblast growth factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 2 and 24-27, encodes isoform 2.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4276.1
    UniProtKB/TrEMBL
    C9JDC5
    Conserved Domains (1) summary
    cl00060
    Location:25 → 57
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

  22. NM_001354961.2 → NP_001341890.1  fibroblast growth factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 2, 23, and 25-27, encodes isoform 2.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4276.1
    UniProtKB/TrEMBL
    C9JDC5
    Conserved Domains (1) summary
    cl00060
    Location:25 → 57
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

  23. NM_001354962.2 → NP_001341891.1  fibroblast growth factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 2, 23, 24, 26, and 27, encodes isoform 2.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4276.1
    UniProtKB/TrEMBL
    C9JDC5
    Conserved Domains (1) summary
    cl00060
    Location:25 → 57
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

  24. NM_001354963.2 → NP_001341892.1  fibroblast growth factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 2, 23-25, and 27, encodes isoform 2.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4276.1
    UniProtKB/TrEMBL
    C9JDC5
    Conserved Domains (1) summary
    cl00060
    Location:25 → 57
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

  25. NM_001354964.2 → NP_001341893.1  fibroblast growth factor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 2 and 23-26, encodes isoform 2.
    Source sequence(s)
    AC005370, AC005592
    Consensus CDS
    CCDS4276.1
    UniProtKB/TrEMBL
    C9JDC5
    Conserved Domains (1) summary
    cl00060
    Location:25 → 57
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

  26. NM_033136.4 → NP_149127.1  fibroblast growth factor 1 isoform 2

    See identical proteins and their annotated locations for NP_149127.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 2 and 23-27 encode the same isoform (2).
    Source sequence(s)
    AC005370, AI283639, DA326831
    Consensus CDS
    CCDS4276.1
    UniProtKB/TrEMBL
    C9JDC5
    Related
    ENSP00000354231.5, ENST00000360966.9
    Conserved Domains (1) summary
    cl00060
    Location:25 → 57
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

  27. NM_033137.4 → NP_149128.1  fibroblast growth factor 1 isoform 3

    See identical proteins and their annotated locations for NP_149128.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks a coding exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005370, AC005592
    UniProtKB/TrEMBL
    C9JDC5, Q16089
    Conserved Domains (1) summary
    cl00060
    Location:25 → 56
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    142592178..142698070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    143123428..143229306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05230.1 GenPept UniProtKB/Swiss-Prot:P05230

Gene LinkOut

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