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Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [ Mus musculus (house mouse) ]

Gene ID: 22627, updated on 9-Dec-2024

Summary

Official Symbol
Ywhaeprovided by MGI
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideprovided by MGI
Primary source
MGI:MGI:894689
See related
Ensembl:ENSMUSG00000020849 AllianceGenome:MGI:894689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein domain specific binding activity; protein phosphatase binding activity; and protein phosphatase inhibitor activity. Acts upstream of or within neuron migration; pallium development; and protein targeting. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Miller-Dieker lissencephaly syndrome and left ventricular noncompaction. Orthologous to human YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E11.5 (RPKM 424.9), CNS E18 (RPKM 417.5) and 25 other tissues See more
Orthologs
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Genomic context

See Ywhae in Genome Data Viewer
Location:
11 B5; 11 45.92 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75620121..75656667)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75732887..75765841)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3975 Neighboring gene myosin IC Neighboring gene STARR-positive B cell enhancer ABC_E7018 Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog Neighboring gene STARR-positive B cell enhancer ABC_E3001 Neighboring gene STARR-positive B cell enhancer ABC_E8425 Neighboring gene predicted gene, 57767 Neighboring gene STARR-seq mESC enhancer starr_30005 Neighboring gene STARR-positive B cell enhancer ABC_E5247 Neighboring gene double C2, beta Neighboring gene STARR-seq mESC enhancer starr_30008 Neighboring gene predicted gene 12339 Neighboring gene rabphilin 3A-like (without C2 domains)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 31
Function Evidence Code Pubs
enables calcium channel inhibitor activity  
enables calcium channel inhibitor activity  
enables calcium channel regulator activity  
enables enzyme binding  
enables histone deacetylase binding  
enables histone deacetylase binding  
enables identical protein binding  
enables identical protein binding  
enables phosphoprotein binding  
enables phosphoserine residue binding  
enables phosphoserine residue binding  
enables phosphoserine residue binding  
enables potassium channel regulator activity  
enables potassium channel regulator activity  
enables protein binding PubMed 
enables protein domain specific binding PubMed 
enables protein heterodimerization activity  
enables protein heterodimerization activity  
enables protein phosphatase binding PubMed 
enables protein phosphatase inhibitor activity PubMed 
enables protein sequestering activity  
enables protein sequestering activity  
enables protein-containing complex binding  
enables scaffold protein binding  
enables scaffold protein binding  
enables signaling adaptor activity  
enables signaling adaptor activity  
enables transmembrane transporter binding  
enables transmembrane transporter binding  
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
Items 1 - 25 of 31
Items 1 - 25 of 35
Process Evidence Code Pubs
involved_in MAPK cascade  
involved_in MAPK cascade  
involved_in cellular response to heat  
involved_in cellular response to heat  
acts_upstream_of_or_within cerebral cortex development PubMed 
involved_in cytoplasmic pattern recognition receptor signaling pathway  
involved_in cytoplasmic pattern recognition receptor signaling pathway  
involved_in cytoplasmic sequestering of protein  
involved_in cytoplasmic sequestering of protein  
acts_upstream_of_or_within hippocampus development PubMed 
involved_in negative regulation of calcium ion export across plasma membrane  
involved_in negative regulation of calcium ion export across plasma membrane  
involved_in negative regulation of toll-like receptor signaling pathway  
involved_in negative regulation of toll-like receptor signaling pathway  
acts_upstream_of_or_within neuron migration PubMed 
acts_upstream_of_or_within neuron migration PubMed 
involved_in positive regulation of hippo signaling  
involved_in positive regulation of hippo signaling  
involved_in positive regulation of protein export from nucleus  
involved_in positive regulation of protein export from nucleus  
involved_in protein localization  
involved_in protein localization to endoplasmic reticulum  
involved_in protein localization to endoplasmic reticulum  
involved_in protein localization to nucleus  
involved_in protein localization to nucleus  
acts_upstream_of_or_within protein targeting PubMed 
involved_in regulation of cytosolic calcium ion concentration  
involved_in regulation of cytosolic calcium ion concentration  
involved_in regulation of membrane repolarization  
involved_in regulation of membrane repolarization  
involved_in regulation of mitotic cell cycle  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
involved_in regulation of potassium ion transmembrane transport  
involved_in regulation of potassium ion transmembrane transporter activity  
involved_in signal transduction  
Items 1 - 25 of 35
Component Evidence Code Pubs
located_in axon  
located_in central region of growth cone  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in endoplasmic reticulum  
is_active_in endoplasmic reticulum  
is_active_in glutamatergic synapse  
part_of kinesin complex  
located_in melanosome  
located_in mitochondrion PubMed 
located_in nucleus  
located_in nucleus  
located_in plasma membrane  
colocalizes_with plasma membrane  
is_active_in synapse  

General protein information

Preferred Names
14-3-3 protein epsilon
Names
14-3-3 epsilon
14-3-3E
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009536.4NP_033562.3  14-3-3 protein epsilon

    See identical proteins and their annotated locations for NP_033562.3

    Status: VALIDATED

    Source sequence(s)
    AK135831, BC058686, BY293945
    Consensus CDS
    CCDS25056.1
    UniProtKB/Swiss-Prot
    P62259
    UniProtKB/TrEMBL
    Q5SS40, Q8BPH1
    Related
    ENSMUSP00000070993.4, ENSMUST00000067664.10
    Conserved Domains (1) summary
    cd10020
    Location:4233
    14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75620121..75656667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156631.1XP_036012524.1  14-3-3 protein epsilon isoform X1

    UniProtKB/TrEMBL
    Q8BPH1
    Conserved Domains (1) summary
    cd10020
    Location:4233
    14-3-3_epsilon; 14-3-3 epsilon, an isoform of 14-3-3 protein
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