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Arhgef4 Rho guanine nucleotide exchange factor 4 [ Mus musculus (house mouse) ]

Gene ID: 226970, updated on 30-Apr-2024

Summary

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Official Symbol
Arhgef4provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 4provided by MGI
Primary source
MGI:MGI:2442507
See related
Ensembl:ENSMUSG00000037509 AllianceGenome:MGI:2442507
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asef; 9330140K16Rik; C230030N03Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Predicted to be involved in filopodium assembly and lamellipodium assembly. Predicted to be located in cytoplasm. Is expressed in spinal cord and ventricular layer. Orthologous to human ARHGEF4 (Rho guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 57.8), frontal lobe adult (RPKM 45.1) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgef4 in Genome Data Viewer
Location:
1 B; 1 13.34 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34717263..34851819)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34677949..34812754)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 19 pseudogene Neighboring gene predicted gene, 38647 Neighboring gene predicted gene, 32920 Neighboring gene alpha-endosulfine pseudogene Neighboring gene STARR-seq mESC enhancer starr_00584 Neighboring gene predicted gene, 32790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:34859246-34859433 Neighboring gene small integral membrane protein 39 Neighboring gene family with sequence similarity 168, member B Neighboring gene STARR-seq mESC enhancer starr_00587 Neighboring gene pleckstrin homology domain containing, family B (evectins) member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:34924123-34924424

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rho Guanine Nucleotide Exchange Factor 4 (Arhgef4) Deficiency Enhances Spatial and Object Recognition Memory. Yoo KS, et al. Exp Neurobiol, 2020 Oct 31. PMID 33154196, Free PMC Article
  2. Asef controls vascular endothelial permeability and barrier recovery in the lung. Tian X, et al. Mol Biol Cell, 2015 Feb 15. PMID 25518936, Free PMC Article
  3. The adenomatous polyposis coli-associated guanine nucleotide exchange factor Asef is involved in angiogenesis. Kawasaki Y, et al. J Biol Chem, 2010 Jan 8. PMID 19897489, Free PMC Article
  4. Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction. Meng F, et al. Am J Physiol Lung Cell Mol Physiol, 2015 Mar 1. PMID 25539852, Free PMC Article
  5. The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. Kawasaki Y, et al. EMBO Rep, 2009 Dec. PMID 19893577, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Asef has a role in HGF-mediated protection against endothelial hyperpermeability and lung injury.
    Title: Asef controls vascular endothelial permeability and barrier recovery in the lung.
  2. these results demonstrate potent anti-inflammatory effects by HGF and delineate a key role of Asef in the mediation of the HGF barrier protective and anti-inflammatory effects.
    Title: Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction.
  3. Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.
    Title: The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 4
Names
APC-stimulated guanine nucleotide exchange factor
Rho guanine nucleotide exchange factor (GEF) 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368773.1 → NP_001355702.1  rho guanine nucleotide exchange factor 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC107738, AC107766, AC157813
    Consensus CDS
    CCDS87817.1
    UniProtKB/TrEMBL
    E9PYK8
    Related
    ENSMUSP00000124213.3, ENSMUST00000159747.9
    Conserved Domains (3) summary
    cd11973
    Location:1344 → 1416
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    cd00160
    Location:1450 → 1631
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01224
    Location:1637 → 1776
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  2. NM_183019.3 → NP_898840.2  rho guanine nucleotide exchange factor 4 isoform 2

    See identical proteins and their annotated locations for NP_898840.2

    Status: VALIDATED

    Source sequence(s)
    AC107738
    Consensus CDS
    CCDS14872.1
    UniProtKB/Swiss-Prot
    Q7TNR9, Q80TJ6
    UniProtKB/TrEMBL
    Q3TDW8, Q3TQN9, Q3UYJ6
    Related
    ENSMUSP00000035980.10, ENSMUST00000047664.16
    Conserved Domains (3) summary
    cd00160
    Location:79 → 260
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01224
    Location:266 → 405
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    cl17036
    Location:1 → 45
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    34717263..34851819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNR9.2 GenPept UniProtKB/Swiss-Prot:Q7TNR9

Gene LinkOut

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