Dnajc2 DnaJ heat shock protein family (Hsp40) member C2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnajc2provided by MGI
Official Full Name: DnaJ heat shock protein family (Hsp40) member C2provided by MGI
Primary source: MGI:MGI:99470
See related: Ensembl:ENSMUSG00000029014 AllianceGenome:MGI:99470
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zrf1; Zrf2; MIDA1
Summary: Predicted to enable several functions, including Hsp70 protein binding activity; ribosome binding activity; and ubiquitin modification-dependent histone binding activity. Acts upstream of or within DNA replication and negative regulation of DNA biosynthetic process. Predicted to be located in cytoplasm; nuclear membrane; and nucleolus. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; blastocyst; brain; hemolymphoid system gland; and reproductive system. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 20.3), CNS E11.5 (RPKM 19.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 9.97 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (21962279..21990183, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (21757266..21785264, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Invalidation of DNAJC2 leads to early post-implantation lethality of mouse embryos. Dnajc2 is expressed throughout early mouse embryogenesis. Maternal Dnajc2 mRNAs allow early preimplantation mouse embryonic development.
Title: DNAJC2 is required for mouse early embryonic development.
These findings reveal a mechanism by which nutrient sensing pathways impact on cell senescence through the activation of mTORC1-S6 kinases and the phosphorylation of ZRF1.
Title: ZRF1 is a novel S6 kinase substrate that drives the senescence programme.
Zrf1 is identified as a novel regulator of the mesodermal lineage that might facilitate spatiotemporal expression of genes.
Title: Zrf1 controls mesoderm lineage genes and cardiomyocyte differentiation.
Data suggest involvement of MIDA1 in the stimulation of transcription in concert with Hsp70/Hsc70 molecular chaperones.
Title: Reporter gene stimulation by MIDA1 through its DnaJ homology region.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136383 (e-PCR)
- UniSTS:210373

RH142375 (e-PCR)
- UniSTS:231622

Dnajc2 (e-PCR), detects polymorphism
- UniSTS:144847

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-modified histone reader activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 'de novo' cotranslational protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational fidelity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dnaJ homolog subfamily C member 2

Names: DnaJ (Hsp40) homolog, subfamily C, member 2; Id associate 1; zuotin related factor 2; zuotin-related factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417606.1 → NP_001404535.1 dnaJ homolog subfamily C member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC125313

UniProtKB/TrEMBL

E9Q9H2

Related

ENSMUSP00000110849.2, ENSMUST00000115195.8
NM_001417607.1 → NP_001404536.1 dnaJ homolog subfamily C member 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC125313

Related

ENSMUST00000147987.2
NM_001417608.1 → NP_001404537.1 dnaJ homolog subfamily C member 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC125313
NM_009584.5 → NP_033610.1 dnaJ homolog subfamily C member 2 isoform 1

See identical proteins and their annotated locations for NP_033610.1

Status: VALIDATED

Source sequence(s)

AC125313

Consensus CDS

CCDS19107.1

UniProtKB/Swiss-Prot

P54103, Q61866

UniProtKB/TrEMBL

E9Q9H3

Related

ENSMUSP00000030771.6, ENSMUST00000030771.12

Conserved Domains (5) summary

smart00717
Location:552 → 602

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

COG5269
Location:75 → 368

ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]

cd00167
Location:553 → 600

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00226
Location:88 → 158

DnaJ; DnaJ domain

pfam16717
Location:349 → 420

RAC_head; Ribosome-associated complex head domain