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Kat14 lysine acetyltransferase 14 [ Mus musculus (house mouse) ]

Gene ID: 228714, updated on 28-Apr-2024

Summary

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Official Symbol
Kat14provided by MGI
Official Full Name
lysine acetyltransferase 14provided by MGI
Primary source
MGI:MGI:1917264
See related
Ensembl:ENSMUSG00000027425 AllianceGenome:MGI:1917264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATAC2; Csrp2bp; D2Wsu131e; D2Ertd473e; E430020F17; 2510008M08Rik
Summary
Predicted to enable histone acetyltransferase activity. Acts upstream of or within G2/M transition of mitotic cell cycle and histone acetylation. Located in nucleus. Part of ATAC complex. Is expressed in embryo and extraembryonic component. Orthologous to human KAT14 (lysine acetyltransferase 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.4), placenta adult (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G1; 2 71.01 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144210952..144249595)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144369032..144407675)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 2_1789.1 Neighboring gene STARR-seq mESC enhancer starr_05912 Neighboring gene calcium binding and coiled-coil domain 2 pseudogene Neighboring gene PET117 homolog Neighboring gene STARR-seq mESC enhancer starr_05913 Neighboring gene predicted gene, 46768 Neighboring gene zinc finger protein 133, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The CSRP2BP histone acetyltransferase drives smooth muscle gene expression. Ma Y, et al. Nucleic Acids Res, 2017 Apr 7. PMID 27940555, Free PMC Article
  2. The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene. Shen AL, et al. PLoS One, 2010 Aug 16. PMID 20808945, Free PMC Article
  3. Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression. Shen AL, et al. PLoS One, 2016. PMID 27310661, Free PMC Article
  4. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
  5. The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes. Nagy Z, et al. Cell Mol Life Sci, 2010 Feb. PMID 19936620

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CSRP2BP strongly potentiates the expression of SRF smooth muscle target genes together with either Myocardin or CRP2
    Title: The CSRP2BP histone acetyltransferase drives smooth muscle gene expression.
  2. Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in Csrp2bp, Dzank1, and Ovol2 gene expression have been reported.
    Title: Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cysteine-rich protein 2-binding protein
Names
ADA2A-containing complex subunit 2
CRP2-binding partner
CRP2BP
CSRP2-binding protein
cysteine and glycine-rich protein 2 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166640.1 → NP_001160112.1  cysteine-rich protein 2-binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL808123
    UniProtKB/TrEMBL
    E9QA90
    Related
    ENSMUSP00000130785.2, ENSMUST00000147747.8
    Conserved Domains (2) summary
    COG0456
    Location:554 → 632
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:552 → 621
    Acetyltransf_1; Acetyltransferase (GNAT) family

  2. NM_181417.3 → NP_852082.2  cysteine-rich protein 2-binding protein isoform 1

    See identical proteins and their annotated locations for NP_852082.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL808123
    Consensus CDS
    CCDS16819.1
    UniProtKB/Swiss-Prot
    A2ANA8, Q8CID0
    Related
    ENSMUSP00000028911.9, ENSMUST00000028911.15
    Conserved Domains (2) summary
    COG0456
    Location:648 → 760
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:680 → 749
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    144210952..144249595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CID0.2 GenPept UniProtKB/Swiss-Prot:Q8CID0

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