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Slc5a9 solute carrier family 5 (sodium/glucose cotransporter), member 9 [ Mus musculus (house mouse) ]

Gene ID: 230612, updated on 11-Apr-2024

Summary

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Official Symbol
Slc5a9provided by MGI
Official Full Name
solute carrier family 5 (sodium/glucose cotransporter), member 9provided by MGI
Primary source
MGI:MGI:2140201
See related
Ensembl:ENSMUSG00000028544 AllianceGenome:MGI:2140201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SGLT4
Summary
Predicted to enable glucose:sodium symporter activity. Predicted to be involved in sodium ion transport. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Orthologous to human SLC5A9 (solute carrier family 5 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 7.9), thymus adult (RPKM 7.5) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D1; 4 51.53 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (111732571..111759993, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (111875374..111902796, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 6 Neighboring gene predicted gene 12961 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:111490159-111490407 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11094 Neighboring gene STARR-seq mESC enhancer starr_11095 Neighboring gene selection and upkeep of intraepithelial T cells 8 Neighboring gene STARR-seq mESC enhancer starr_11097 Neighboring gene STARR-seq mESC enhancer starr_11098 Neighboring gene selection and upkeep of intraepithelial T cells 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Tazawa S, et al. Life Sci, 2005 Jan 14. PMID 15607332
  2. Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Wiley LM, et al. Dev Biol, 1991 Jan. PMID 1702069
  3. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SGLT4 would have unique physiological functions (i.e., absorption and/or reabsorption of Man, 1,5AG, and Fru, in addition to Glc).
    Title: SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC29197

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glucose:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium/glucose cotransporter 4
Names
Na(+)/glucose cotransporter 4
mSGLT4
solute carrier family 5 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145551.4 → NP_663526.3  sodium/glucose cotransporter 4

    See identical proteins and their annotated locations for NP_663526.3

    Status: VALIDATED

    Source sequence(s)
    AI159731, AK028743, AK029158, AK033425
    Consensus CDS
    CCDS18474.1
    UniProtKB/Swiss-Prot
    Q8BGU9, Q8BZW1, Q8VDT1
    Related
    ENSMUSP00000099782.2, ENSMUST00000102721.8
    Conserved Domains (1) summary
    cl00456
    Location:45 → 685
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    111732571..111759993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503000.3 → XP_006503063.1  sodium/glucose cotransporter 4 isoform X1

    See identical proteins and their annotated locations for XP_006503063.1

    UniProtKB/Swiss-Prot
    Q8BGU9, Q8BZW1, Q8VDT1
    Related
    ENSMUSP00000099780.2, ENSMUST00000102719.8
    Conserved Domains (1) summary
    cl00456
    Location:45 → 685
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_006503001.2 → XP_006503064.1  sodium/glucose cotransporter 4 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:1 → 593
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_006503002.4 → XP_006503065.1  sodium/glucose cotransporter 4 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:45 → 377
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_376307.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDT1.3 GenPept UniProtKB/Swiss-Prot:Q8VDT1

Gene LinkOut

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