Phf13 PHD finger protein 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Phf13provided by MGI
Official Full Name: PHD finger protein 13provided by MGI
Primary source: MGI:MGI:2446217
See related: Ensembl:ENSMUSG00000047777 AllianceGenome:MGI:2446217
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Phf5; SPOC1
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in mitotic chromosome condensation. Predicted to act upstream of or within cell division; chromatin organization; and chromosome condensation. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; early conceptus; ganglia; genitourinary system; and sensory organ. Orthologous to human PHF13 (PHD finger protein 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 19.0), ovary adult (RPKM 18.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 82.81 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (152074088..152080636, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (151989631..151996179, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rods fail to robustly accumulate active ATM at DNA double-strand breakd, exhibit low KAP1 levels, and display high levels of SPOC1, a factor suppressing KAP1 phosphorylation. This results in dramatically reduced KAP1 phosphorylation.
Title: Inefficient double-strand break repair in murine rod photoreceptors with inverted heterochromatin organization.
indispensable for stem cell differentiation in the testis and for sustained spermatogenesis
Title: SPOC1 (PHF13) is required for spermatogonial stem cell differentiation and sustained spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2) 1 citation

General gene information

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Markers

UniSTS:496742 (e-PCR)
- UniSTS:496742

Phf13 (e-PCR), detects polymorphism
- UniSTS:496742

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin-protein adaptor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA repair	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PHD finger protein 13

Names: PHD zinc finger protein PHF5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.