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Cnot6l CCR4-NOT transcription complex, subunit 6-like [ Mus musculus (house mouse) ]

Gene ID: 231464, updated on 12-May-2024

Summary

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Official Symbol
Cnot6lprovided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 6-likeprovided by MGI
Primary source
MGI:MGI:2443154
See related
Ensembl:ENSMUSG00000034724 AllianceGenome:MGI:2443154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932442K20Rik
Summary
Enables poly(A)-specific ribonuclease activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and positive regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and white fat. Orthologous to human CNOT6L (CCR4-NOT transcription complex subunit 6 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 4.5), bladder adult (RPKM 3.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Cnot6l in Genome Data Viewer
Location:
5 E3; 5 47.29 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (96218192..96312044, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (96070333..96164198, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 13 Neighboring gene STARR-seq mESC enhancer starr_13673 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:96589986-96590095 Neighboring gene STARR-positive B cell enhancer mm9_chr5:96592485-96592786 Neighboring gene STARR-positive B cell enhancer ABC_E2159 Neighboring gene STARR-positive B cell enhancer mm9_chr5:96638970-96639271 Neighboring gene STARR-positive B cell enhancer ABC_E10331 Neighboring gene STARR-positive B cell enhancer ABC_E6348 Neighboring gene STARR-seq mESC enhancer starr_13674 Neighboring gene STARR-seq mESC enhancer starr_13675 Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene predicted gene, 33050

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of Cnot6l in maternal mRNA turnover. Horvat F, et al. Life Sci Alliance, 2018 Aug. PMID 30456367, Free PMC Article
  2. CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development. Dai XX, et al. Cell Rep, 2021 Nov 16. PMID 34788619
  3. Loss of Cnot6l Impairs Inosine RNA Modifications in Mouse Oocytes. Brachova P, et al. Int J Mol Sci, 2021 Jan 26. PMID 33530472, Free PMC Article
  4. Identification of Novel Binding Partners for Transcription Factor Emx2. Groves JA, et al. Protein J, 2019 Feb. PMID 30628007
  5. CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte. Sha QQ, et al. EMBO J, 2018 Dec 14. PMID 30478191, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.
    Title: Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.
  2. CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.
    Title: CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development.
  3. FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development.
    Title: FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development.
  4. Loss of Cnot6l Impairs Inosine RNA Modifications in Mouse Oocytes.
    Title: Loss of Cnot6l Impairs Inosine RNA Modifications in Mouse Oocytes.
  5. This study provides the first direct genetic evidence that CCR4-NOT-dependent and particularly CNOT6L-dependent decay of selective maternal mRNAs is a prerequisite for meiotic maturation of oocytes.
    Title: CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte.
  6. Using the 3'-UTRs of mouse Cpeb1, Btg4 and Cnot6l mRNAs, we deciphered the combinatorial code that controls developmental stage-specific translation during meiotic maturation
    Title: A combinatorial code for mRNA 3'-UTR-mediated translational control in the mouse oocyte.
  7. This initial screen isolated two potential Emx2-binding partner proteins, Cnot6l and QkI-7. These novel Emx2-binding proteins are involved in multiple levels of mRNA metabolism that including splicing, mRNA export, translation, and destruction
    Title: Identification of Novel Binding Partners for Transcription Factor Emx2.
  8. CCR4b may be involved in various cellular events that include cell proliferation.
    Title: Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29037, DKFZp434K098

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A)-specific ribonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables poly(A)-specific ribonuclease activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytoplasmic mRNA processing body assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 6-like
NP_001272440.1
NP_001272443.1
NP_659159.1
NP_849185.2
XP_006534933.1
XP_006534934.1
XP_006534935.1
XP_030110258.1
XP_030110259.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285511.1 → NP_001272440.1  CCR4-NOT transcription complex subunit 6-like isoform 1

    See identical proteins and their annotated locations for NP_001272440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (1), which is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AC129600, AK030112, AK151728
    Consensus CDS
    CCDS19448.1
    UniProtKB/Swiss-Prot
    Q8VEG6
    Conserved Domains (3) summary
    cd10312
    Location:186 → 533
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52 → 178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:33 → 52
    LRR_1; leucine-rich repeat [structural motif]

  2. NM_001285514.1 → NP_001272443.1  CCR4-NOT transcription complex subunit 6-like isoform 3

    See identical proteins and their annotated locations for NP_001272443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 2.
    Source sequence(s)
    AC129600, AK030112, AK151728
    UniProtKB/Swiss-Prot
    Q8VEG6
    Conserved Domains (2) summary
    cd10312
    Location:91 → 438
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:3 → 83
    LRR; Leucine-rich repeat (LRR) protein [Transcription]

  3. NM_144910.2 → NP_659159.1  CCR4-NOT transcription complex subunit 6-like isoform 1

    See identical proteins and their annotated locations for NP_659159.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (1), which is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AC129600, AK030112, AK151728, BC018506, CF173938
    Consensus CDS
    CCDS19448.1
    UniProtKB/Swiss-Prot
    Q8VEG6
    Related
    ENSMUSP00000119415.2, ENSMUST00000155901.8
    Conserved Domains (3) summary
    cd10312
    Location:186 → 533
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52 → 178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:33 → 52
    LRR_1; leucine-rich repeat [structural motif]

  4. NM_178854.4 → NP_849185.2  CCR4-NOT transcription complex subunit 6-like isoform 2

    See identical proteins and their annotated locations for NP_849185.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AC129600, AK030112, AK151728
    Consensus CDS
    CCDS51566.1
    UniProtKB/Swiss-Prot
    Q3U9M0, Q8C0P4, Q8VEG6
    Related
    ENSMUSP00000108629.3, ENSMUST00000113005.9
    Conserved Domains (3) summary
    cd10312
    Location:191 → 538
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:57 → 183
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:38 → 57
    LRR_1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    96218192..96312044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534870.5 → XP_006534933.1  CCR4-NOT transcription complex subunit 6-like isoform X1

    See identical proteins and their annotated locations for XP_006534933.1

    UniProtKB/Swiss-Prot
    Q8VEG6
    Conserved Domains (3) summary
    cd10312
    Location:186 → 533
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52 → 178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:33 → 52
    LRR_1; leucine-rich repeat [structural motif]

  2. XM_030254398.1 → XP_030110258.1  CCR4-NOT transcription complex subunit 6-like isoform X2

    Conserved Domains (2) summary
    cd10312
    Location:91 → 438
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:3 → 83
    LRR; Leucine-rich repeat (LRR) protein [Transcription]

  3. XM_006534871.3 → XP_006534934.1  CCR4-NOT transcription complex subunit 6-like isoform X1

    See identical proteins and their annotated locations for XP_006534934.1

    UniProtKB/Swiss-Prot
    Q8VEG6
    Conserved Domains (3) summary
    cd10312
    Location:186 → 533
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52 → 178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:33 → 52
    LRR_1; leucine-rich repeat [structural motif]

  4. XM_030254399.2 → XP_030110259.1  CCR4-NOT transcription complex subunit 6-like isoform X2

    Conserved Domains (2) summary
    cd10312
    Location:91 → 438
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:3 → 83
    LRR; Leucine-rich repeat (LRR) protein [Transcription]

  5. XM_006534872.4 → XP_006534935.1  CCR4-NOT transcription complex subunit 6-like isoform X3

    Conserved Domains (1) summary
    cd10312
    Location:50 → 397
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEG6.2 GenPept UniProtKB/Swiss-Prot:Q8VEG6

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