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Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 [ Mus musculus (house mouse) ]

Gene ID: 231872, updated on 5-Mar-2024

Summary

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Official Symbol
Aimp2provided by MGI
Official Full Name
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2provided by MGI
Primary source
MGI:MGI:2385237
See related
Ensembl:ENSMUSG00000029610 AllianceGenome:MGI:2385237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jtv1; Aimp2(p38)
Summary
Enables molecular adaptor activity. Involved in positive regulation of aminoacyl-tRNA ligase activity and protein-containing complex assembly. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of protein ubiquitination; and type II pneumocyte differentiation. Located in nucleus. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including olfactory epithelium; orbito-sphenoid; submandibular gland primordium; thymus primordium; and tooth. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human AIMP2 (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 41.7), liver E14.5 (RPKM 30.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Aimp2 in Genome Data Viewer
Location:
5 G2; 5 82.8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143839522..143846657, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143902704..143909839, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D130017N08 gene Neighboring gene STARR-positive B cell enhancer ABC_E10364 Neighboring gene STARR-positive B cell enhancer ABC_E2182 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61 Neighboring gene STARR-positive B cell enhancer ABC_E858 Neighboring gene PMS1 homolog2, mismatch repair system component Neighboring gene CCZ1 vacuolar protein trafficking and biogenesis associated Neighboring gene STARR-positive B cell enhancer ABC_E6396 Neighboring gene predicted gene, 24311 Neighboring gene predicted gene, 54312 Neighboring gene predicted gene, 33427

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death. Kook MG, et al. Mol Neurobiol, 2023 Jan. PMID 36242734
  2. Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis. Choi JW, et al. Carcinogenesis, 2009 Sep. PMID 19622630
  3. Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression. Oh AY, et al. Cancer Res, 2016 Aug 15. PMID 27302160
  4. Autophagy-mediated clearance of aggresomes is not a universal phenomenon. Wong ES, et al. Hum Mol Genet, 2008 Aug 15. PMID 18502787, Free PMC Article
  5. AIMP2 Controls Intestinal Stem Cell Compartments and Tumorigenesis by Modulating Wnt/β-Catenin Signaling. Yum MK, et al. Cancer Res, 2016 Aug 1. PMID 27262173

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death.
    Title: Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death.
  2. our findings show how DX2 promotes lung cancer progression and how its activity may be thwarted as a strategy to treat patients with lung cancers exhibiting elevated DX2 levels
    Title: Inhibiting DX2-p14/ARF Interaction Exerts Antitumor Effects in Lung Cancer and Delays Tumor Progression.
  3. functional significance of AIMP2 in determination of cell proliferation and death, and as a haploinsufficient tumor suppressor.
    Title: Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30261, MGC36346, MGC36522, MGC37389

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within type II pneumocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Names
ARS interacting multifunctional protein 2
multisynthase complex auxiliary component p38
multisynthetase complex auxiliary component p38
protein JTV-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172146.1 → NP_001165617.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001165617.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BY202241, CF732613, CX566811
    Consensus CDS
    CCDS51692.1
    UniProtKB/Swiss-Prot
    E9QP67, Q8R010, Q8R2Y6
    Related
    ENSMUSP00000031613.5, ENSMUST00000031613.11
    Conserved Domains (2) summary
    cd03200
    Location:214 → 309
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2
    pfam16780
    Location:1 → 33
    AIMP2_LysRS_bd; AIMP2 lysyl-tRNA synthetase binding domain

  2. NM_146165.2 → NP_666277.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 2 isoform 2

    See identical proteins and their annotated locations for NP_666277.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the N-terminus, compared to isoform 1.
    Source sequence(s)
    BY202241, CJ051555, CX566811
    Consensus CDS
    CCDS39374.1
    UniProtKB/TrEMBL
    Q8R3V2
    Related
    ENSMUSP00000098052.3, ENSMUST00000100483.3
    Conserved Domains (1) summary
    cd03200
    Location:174 → 269
    GST_C_AIMP2; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    143839522..143846657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R010.2 GenPept UniProtKB/Swiss-Prot:Q8R010

Gene LinkOut

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