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Cpa2 carboxypeptidase A2, pancreatic [ Mus musculus (house mouse) ]

Gene ID: 232680, updated on 9-May-2024

Summary

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Official Symbol
Cpa2provided by MGI
Official Full Name
carboxypeptidase A2, pancreaticprovided by MGI
Primary source
MGI:MGI:3617840
See related
Ensembl:ENSMUSG00000071553 AllianceGenome:MGI:3617840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. The encoded preproprotein undergoes proteolytic processing that removes the N-terminal activation peptide to generate a functional enzyme. This gene is expressed by the pancreatic exocrine cells which secrete the enzyme during digestion. This gene is located in a cluster of carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jul 2016]
Expression
Biased expression in spleen adult (RPKM 67.2), small intestine adult (RPKM 62.2) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A3.3; 6 12.52 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30541641..30564475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30541642..30564476)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 209 Neighboring gene STARR-seq mESC enhancer starr_15468 Neighboring gene serine-rich single-pass membrane protein 1 Neighboring gene predicted gene, 53278 Neighboring gene carboxypeptidase A4 Neighboring gene predicted gene, 31453

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional Trajectories in Mouse Limb Buds Reveal the Transition from Anterior-Posterior to Proximal-Distal Patterning at Early Limb Bud Stage. Desanlis I, et al. J Dev Biol, 2020 Dec 7. PMID 33297480, Free PMC Article
  2. The single-cell transcriptional landscape of mammalian organogenesis. Cao J, et al. Nature, 2019 Feb. PMID 30787437, Free PMC Article
  3. p27 Regulates the transition of beta-cells from quiescence to proliferation. Georgia S, et al. Diabetes, 2006 Nov. PMID 17065330
  4. Wnt/beta-catenin signaling is required for development of the exocrine pancreas. Wells JM, et al. BMC Dev Biol, 2007 Jan 12. PMID 17222338, Free PMC Article
  5. Conditional ablation of Notch signaling in pancreatic development. Nakhai H, et al. Development, 2008 Aug. PMID 18635610

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC107514

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxypeptidase A2
NP_001019869.1
XP_011239359.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024698.3 → NP_001019869.1  carboxypeptidase A2 preproprotein

    See identical proteins and their annotated locations for NP_001019869.1

    Status: REVIEWED

    Source sequence(s)
    BB610349, BP772440, CO428705
    Consensus CDS
    CCDS19974.1
    UniProtKB/Swiss-Prot
    Q504N0
    Related
    ENSMUSP00000093771.5, ENSMUST00000096066.5
    Conserved Domains (2) summary
    cd03870
    Location:116 → 415
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    pfam02244
    Location:27 → 99
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30541641..30564475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241057.2 → XP_011239359.1  carboxypeptidase A2 isoform X1

    Conserved Domains (1) summary
    cd03870
    Location:13 → 312
    M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q504N0.1 GenPept UniProtKB/Swiss-Prot:Q504N0

Gene LinkOut

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