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Adamts17 ADAM metallopeptidase with thrombospondin type 1 motif 17 [ Mus musculus (house mouse) ]

Gene ID: 233332, updated on 12-May-2024

Summary

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Official Symbol
Adamts17provided by MGI
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 17provided by MGI
Primary source
MGI:MGI:3588195
See related
Ensembl:ENSMUSG00000058145 AllianceGenome:MGI:3588195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Located in collagen-containing extracellular matrix. Is expressed in embryo and eye. Used to study Weill-Marchesani syndrome. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS17 (ADAM metallopeptidase with thrombospondin type 1 motif 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 4.9), lung adult (RPKM 1.5) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 C; 7 36.26 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (66487387..66802373)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (66839699..67153171)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1735 Neighboring gene ankyrin repeat and SOCS box-containing 7 Neighboring gene lines homolog 1 Neighboring gene ceramide synthase 3 Neighboring gene STARR-seq mESC enhancer starr_19091 Neighboring gene predicted gene, 33627 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:74058062-74058215 Neighboring gene predicted gene, 51511 Neighboring gene predicted gene, 53393 Neighboring gene Y box protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19094 Neighboring gene RIKEN cDNA 1700112J16 gene Neighboring gene STARR-positive B cell enhancer ABC_E4933 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. Morales J, et al. Am J Hum Genet, 2009 Nov. PMID 19836009, Free PMC Article
  2. Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway. Oichi T, et al. Cell Mol Life Sci, 2019 Dec. PMID 31201465, Free PMC Article
  3. Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics. Dubail J, et al. Matrix Biol, 2015 May-Jul. PMID 25770910
  4. Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development. Mead TJ, et al. Elife, 2022 May 3. PMID 35503090, Free PMC Article
  5. Tracing the origin of hair follicle stem cells. Morita R, et al. Nature, 2021 Jun. PMID 34108685

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 17
Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033877.4 → NP_001029049.2  A disintegrin and metalloproteinase with thrombospondin motifs 17 precursor

    Status: VALIDATED

    Source sequence(s)
    AC119810, AK053131, BG085304, CF741491, CN530432, CO043544, CX769149
    Consensus CDS
    CCDS21349.2
    UniProtKB/TrEMBL
    D3YX90, E9Q4D1
    Related
    ENSMUSP00000095984.4, ENSMUST00000098382.10
    Conserved Domains (7) summary
    smart00209
    Location:544 → 596
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:230 → 447
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam00090
    Location:892 → 946
    TSP_1; Thrombospondin type 1 domain
    pfam01421
    Location:230 → 447
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:75 → 179
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:698 → 808
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1080 → 1106
    PLAC; PLAC (protease and lacunin) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    66487387..66802373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540842.5 → XP_006540905.1  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform X1

    Conserved Domains (5) summary
    smart00209
    Location:544 → 596
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:230 → 447
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:35 → 179
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:698 → 808
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam17771
    Location:464 → 531
    ADAM_CR_2; ADAM cysteine-rich domain

  2. XM_006540843.5 → XP_006540906.1  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform X2

    Conserved Domains (5) summary
    smart00209
    Location:544 → 596
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:230 → 447
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:35 → 179
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:698 → 808
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam17771
    Location:464 → 531
    ADAM_CR_2; ADAM cysteine-rich domain

  3. XM_006540844.5 → XP_006540907.1  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform X3

    Conserved Domains (5) summary
    smart00209
    Location:544 → 596
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:230 → 447
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:35 → 179
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:698 → 808
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam17771
    Location:464 → 531
    ADAM_CR_2; ADAM cysteine-rich domain

  4. XM_006540845.5 → XP_006540908.1  A disintegrin and metalloproteinase with thrombospondin motifs 17 isoform X4

    Conserved Domains (5) summary
    smart00209
    Location:303 → 355
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:1 → 206
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:457 → 567
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam17771
    Location:223 → 290
    ADAM_CR_2; ADAM cysteine-rich domain
    cl15278
    Location:651 → 705
    TSP_1; Thrombospondin type 1 domain
Nucleotide Protein Strain
Heading Accession and Version

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