U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp553 zinc finger protein 553 [ Mus musculus (house mouse) ]

Gene ID: 233887, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp553provided by MGI
Official Full Name
zinc finger protein 553provided by MGI
Primary source
MGI:MGI:2384725
See related
Ensembl:ENSMUSG00000045598 AllianceGenome:MGI:2384725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf48; 2600009K23Rik; C330013F15Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; sensory organ; and skeleton. Orthologous to human ZNF48 (zinc finger protein 48). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 13.4), CNS E11.5 (RPKM 12.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zfp553 in Genome Data Viewer
Location:
7 F3; 7 69.4 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126832233..126837369)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127233061..127238197)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 10b Neighboring gene STARR-positive B cell enhancer ABC_E158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134353944-134354145 Neighboring gene myosin light chain, phosphorylatable, fast skeletal muscle Neighboring gene septin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134361531-134361732 Neighboring gene STARR-seq mESC enhancer starr_20173 Neighboring gene STARR-seq mESC enhancer starr_20176 Neighboring gene predicted gene 4532 Neighboring gene STARR-seq mESC enhancer starr_20179 Neighboring gene STARR-positive B cell enhancer ABC_E6605 Neighboring gene zinc finger protein 771 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134404258-134404441 Neighboring gene dCTP pyrophosphatase 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Zfp553 Is Essential for Maintenance and Acquisition of Pluripotency. Yu S, et al. Stem Cells Dev, 2016 Jan 1. PMID 26423361
  2. Comprehensive interactome of Otx2 in the adult mouse neural retina. Fant B, et al. Genesis, 2015 Nov. PMID 26426291
  3. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC31231

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 48

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360912.1 → NP_001347841.1  zinc finger protein 48

    Status: VALIDATED

    Source sequence(s)
    AC133494, AK146581
    Consensus CDS
    CCDS21860.1
    UniProtKB/Swiss-Prot
    Q3UFP3, Q3US17, Q8R0V0, Q921H7
    Related
    ENSMUSP00000060967.7, ENSMUST00000056232.7
    Conserved Domains (3) summary
    COG5048
    Location:161 → 572
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:85 → 105
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:97 → 120
    zf-H2C2_2; Zinc-finger double domain

  2. NM_146201.2 → NP_666313.1  zinc finger protein 48

    See identical proteins and their annotated locations for NP_666313.1

    Status: VALIDATED

    Source sequence(s)
    AC133494, AK049208
    Consensus CDS
    CCDS21860.1
    UniProtKB/Swiss-Prot
    Q3UFP3, Q3US17, Q8R0V0, Q921H7
    Related
    ENSMUSP00000101919.4, ENSMUST00000106312.4
    Conserved Domains (3) summary
    COG5048
    Location:161 → 572
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:85 → 105
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:97 → 120
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126832233..126837369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3US17.2 GenPept UniProtKB/Swiss-Prot:Q3US17

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous