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FOLR2 folate receptor beta [ Homo sapiens (human) ]

Gene ID: 2350, updated on 4-Jan-2025

Summary

Official Symbol
FOLR2provided by HGNC
Official Full Name
folate receptor betaprovided by HGNC
Primary source
HGNC:HGNC:3793
See related
Ensembl:ENSG00000165457 MIM:136425; AllianceGenome:HGNC:3793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP; FOLR1; FR-P3; FRbeta; FR-BETA; BETA-HFR; FBP/PL-1
Summary
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 67.9), gall bladder (RPKM 33.0) and 20 other tissues See more
Orthologs
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Genomic context

See FOLR2 in Genome Data Viewer
Location:
11q13.4
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72216794..72221950)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (72143410..72148566)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71927838..71932994)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene folate receptor 3 pseudogene 1 Neighboring gene folate receptor alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3717 Neighboring gene skeletal muscle cis-regulatory module in INPPL1 intron Neighboring gene inositol polyphosphate phosphatase like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3718 Neighboring gene paired like homeobox 2A Neighboring gene dedicator of cytokinesis 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of folate receptor 2 (FOLR2) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cell surface PubMed 
is_active_in external side of plasma membrane  
located_in external side of plasma membrane PubMed 
located_in extracellular region  
located_in plasma membrane  

General protein information

Preferred Names
folate receptor beta
Names
folate receptor 2 (fetal)
folate receptor alpha
folate receptor, fetal/placental
folate-binding protein, fetal/placental
placental folate-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000803.5NP_000794.3  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_000794.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
    Source sequence(s)
    AK222643, CD014063
    Consensus CDS
    CCDS8212.1
    UniProtKB/Swiss-Prot
    P14207, Q05CA5, Q6GTE8
    UniProtKB/TrEMBL
    Q53HP1
    Related
    ENSP00000298223.6, ENST00000298223.11
    Conserved Domains (1) summary
    pfam03024
    Location:30205
    Folate_rec; Folate receptor family
  2. NM_001113534.2NP_001107006.1  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_001107006.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    BM849995, CD014063, CD692073
    Consensus CDS
    CCDS8212.1
    UniProtKB/Swiss-Prot
    P14207, Q05CA5, Q6GTE8
    UniProtKB/TrEMBL
    Q53HP1
    Conserved Domains (1) summary
    pfam03024
    Location:30205
    Folate_rec; Folate receptor family
  3. NM_001113535.2NP_001107007.1  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_001107007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    BM691283, BM849995, CD014063
    Consensus CDS
    CCDS8212.1
    UniProtKB/Swiss-Prot
    P14207, Q05CA5, Q6GTE8
    UniProtKB/TrEMBL
    Q53HP1
    Conserved Domains (1) summary
    pfam03024
    Location:30205
    Folate_rec; Folate receptor family
  4. NM_001113536.2NP_001107008.1  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_001107008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    BY797003, CD014063
    Consensus CDS
    CCDS8212.1
    UniProtKB/Swiss-Prot
    P14207, Q05CA5, Q6GTE8
    UniProtKB/TrEMBL
    Q53HP1
    Conserved Domains (1) summary
    pfam03024
    Location:30205
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    72216794..72221950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426683.1XP_047282639.1  folate receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P14207, Q05CA5, Q6GTE8
    UniProtKB/TrEMBL
    Q53HP1
  2. XM_005273856.5XP_005273913.1  folate receptor beta isoform X1

    UniProtKB/TrEMBL
    Q53HP1
    Conserved Domains (1) summary
    pfam03024
    Location:39214
    Folate_rec; Folate receptor family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    72143410..72148566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368249.1XP_054224224.1  folate receptor beta isoform X2

    UniProtKB/Swiss-Prot
    P14207, Q05CA5, Q6GTE8
    UniProtKB/TrEMBL
    Q53HP1
  2. XM_054368248.1XP_054224223.1  folate receptor beta isoform X1

    UniProtKB/TrEMBL
    Q53HP1
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