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Foxred1 FAD-dependent oxidoreductase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 235169, updated on 9-May-2024

Summary

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Official Symbol
Foxred1provided by MGI
Official Full Name
FAD-dependent oxidoreductase domain containing 1provided by MGI
Primary source
MGI:MGI:2446262
See related
Ensembl:ENSMUSG00000039048 AllianceGenome:MGI:2446262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tex23; TEG-23
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 19. Orthologous to human FOXRED1 (FAD dependent oxidoreductase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 17.5), subcutaneous fat pad adult (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A4; 9 20.08 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35115504..35122499, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35204208..35211171, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene decapping enzyme, scavenger Neighboring gene predicted gene, 24262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:34983517-34983704 Neighboring gene STARR-positive B cell enhancer ABC_E6723 Neighboring gene toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Neighboring gene predicted gene, 39318 Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene STARR-seq mESC enhancer starr_23764 Neighboring gene STARR-seq mESC enhancer starr_23765 Neighboring gene signal recognition particle receptor alpha Neighboring gene family with sequence similarity 118, member B Neighboring gene STARR-positive B cell enhancer ABC_E3823 Neighboring gene RNA pseudouridylate synthase domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. López-Fernández LA, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464256
  2. Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. López-Fernández LA, et al. Mamm Genome, 1996 Sep. PMID 8703127
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC38853

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FAD-dependent oxidoreductase domain-containing protein 1
Names
testis expressed gene 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291448.2 → NP_001278377.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001278377.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 2.
    Source sequence(s)
    AC140448
    Consensus CDS
    CCDS80974.1
    UniProtKB/Swiss-Prot
    Q3TQB2, Q8R1D0
    Related
    ENSMUSP00000118037.2, ENSMUST00000127996.8
    Conserved Domains (2) summary
    COG0665
    Location:60 → 479
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    cl21454
    Location:65 → 98
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001291449.2 → NP_001278378.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice near its 5' end that results in translation initiation at a downstream AUG compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC140448
    Conserved Domains (1) summary
    COG0665
    Location:3 → 302
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  3. NM_001359815.2 → NP_001346744.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice near its 5' end that results in translation initiation at a downstream AUG compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AC140448
    Conserved Domains (1) summary
    COG0665
    Location:3 → 302
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  4. NM_001421609.1 → NP_001408538.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140448

  5. NM_001421610.1 → NP_001408539.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140448

  6. NM_172291.3 → NP_758495.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_758495.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC140448
    Consensus CDS
    CCDS22958.1
    UniProtKB/Swiss-Prot
    Q3TQB2
    Related
    ENSMUSP00000038924.9, ENSMUST00000043805.15
    Conserved Domains (2) summary
    COG0665
    Location:60 → 485
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    cl21454
    Location:65 → 98
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_185317.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140448

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35115504..35122499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244290.2 → XP_030100150.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

    Conserved Domains (1) summary
    COG0665
    Location:1 → 291
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  2. XM_011242483.4 → XP_011240785.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011240785.1

    Conserved Domains (1) summary
    COG0665
    Location:3 → 308
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  3. XM_017313309.3 → XP_017168798.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    COG0665
    Location:60 → 404
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  4. XM_006510223.5 → XP_006510286.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    COG0665
    Location:60 → 410
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  5. XM_030244288.2 → XP_030100148.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

    Conserved Domains (1) summary
    COG0665
    Location:1 → 291
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  6. XM_006510226.5 → XP_006510289.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X5

    Conserved Domains (1) summary
    COG0665
    Location:1 → 297
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  7. XM_036154879.1 → XP_036010772.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

    Related
    ENSMUST00000130072.8
    Conserved Domains (1) summary
    COG0665
    Location:1 → 291
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  8. XM_030244291.2 → XP_030100151.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

    Conserved Domains (1) summary
    COG0665
    Location:1 → 291
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  9. XM_036154873.1 → XP_036010766.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    COG0665
    Location:3 → 308
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  10. XM_036154874.1 → XP_036010767.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    COG0665
    Location:3 → 308
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  11. XM_030244289.2 → XP_030100149.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

    Conserved Domains (1) summary
    COG0665
    Location:1 → 291
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  12. XM_006510224.5 → XP_006510287.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006510287.1

    Conserved Domains (1) summary
    COG0665
    Location:3 → 308
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  13. XM_036154875.1 → XP_036010768.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    COG0665
    Location:3 → 302
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  14. XM_036154872.1 → XP_036010765.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    COG0665
    Location:3 → 308
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

  15. XM_036154877.1 → XP_036010770.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X5

    Related
    ENSMUST00000143039.8
    Conserved Domains (1) summary
    COG0665
    Location:1 → 297
    DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

RNA

  1. XR_004935399.1 RNA Sequence

  2. XR_004935398.1 RNA Sequence

  3. XR_003947868.2 RNA Sequence

  4. XR_379114.5 RNA Sequence

  5. XR_379113.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TQB2.1 GenPept UniProtKB/Swiss-Prot:Q3TQB2

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