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Ggt5 gamma-glutamyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 23887, updated on 14-May-2024

Summary

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Official Symbol
Ggt5provided by MGI
Official Full Name
gamma-glutamyltransferase 5provided by MGI
Primary source
MGI:MGI:1346063
See related
Ensembl:ENSMUSG00000006344 AllianceGenome:MGI:1346063
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GGL; Ggtla1; GGT-REL
Summary
Enables leukotriene-C(4) hydrolase. Acts upstream of or within inflammatory response and leukotriene D4 biosynthetic process. Located in plasma membrane. Orthologous to human GGT5 (gamma-glutamyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 21.4), mammary gland adult (RPKM 16.4) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Ggt5 in Genome Data Viewer
Location:
10 C1; 10 38.55 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75425161..75453034)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75589327..75617200)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 75B Neighboring gene gamma-glutamyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E5147 Neighboring gene predicted gene, 26402 Neighboring gene predicted gene, 19688 Neighboring gene sushi domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Augmented expression of gamma-glutamyl transferase 5 (GGT5) impairs testicular steroidogenesis by deregulating local oxidative stress. Li W, et al. Cell Tissue Res, 2016 Nov. PMID 27397680
  2. Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response. Shi ZZ, et al. Mol Cell Biol, 2001 Aug. PMID 11463821, Free PMC Article
  3. Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene. Habib GM, et al. Adv Exp Med Biol, 1999. PMID 10667344
  4. gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. Carter BZ, et al. J Biol Chem, 1998 Oct 23. PMID 9774450
  5. Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. Han B, et al. Am J Pathol, 2002 Aug. PMID 12163373, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
    Title: Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione.
  2. GGT5/oxidative stress cascade plays a central role during luteinizing hormone-stimulated steroidogenesis.
    Title: Augmented expression of gamma-glutamyl transferase 5 (GGT5) impairs testicular steroidogenesis by deregulating local oxidative stress.
  3. plays an important role in inflammatory processes
    Title: Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC132842

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene C4 gamma-glutamyl transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-C(4) hydrolase IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene-C(4) hydrolase IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables leukotriene-C(4) hydrolase ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leukotriene D4 biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within leukotriene D4 biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within leukotriene D4 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leukotriene D4 biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within leukotriene biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione hydrolase 5 proenzyme
Names
gamma-glutamyl leukotrienase
gamma-glutamyltransferase-like activity 1
gamma-glutamyltranspeptidase 5
leukotriene-C4 hydrolase
NP_001346354.1
NP_035950.2
XP_006513710.1
XP_030100950.1
XP_036011677.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359425.2 → NP_001346354.1  glutathione hydrolase 5 proenzyme isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087540
    Conserved Domains (1) summary
    cl19223
    Location:1 → 296
    G_glu_transpept; Gamma-glutamyltranspeptidase

  2. NM_001428895.1 → NP_001415824.1  glutathione hydrolase 5 proenzyme isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC087540

  3. NM_001428896.1 → NP_001415825.1  glutathione hydrolase 5 proenzyme isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087540

  4. NM_011820.6 → NP_035950.2  glutathione hydrolase 5 proenzyme isoform 1 precursor

    See identical proteins and their annotated locations for NP_035950.2

    Status: VALIDATED

    Source sequence(s)
    AC087540
    Consensus CDS
    CCDS23928.1
    UniProtKB/Swiss-Prot
    Q8C7B4, Q9Z2A9
    Related
    ENSMUSP00000072074.3, ENSMUST00000072217.9
    Conserved Domains (1) summary
    pfam01019
    Location:60 → 568
    G_glu_transpept; Gamma-glutamyltranspeptidase

RNA

  1. NR_153110.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087540

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    75425161..75453034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245090.1 → XP_030100950.1  glutathione hydrolase 5 proenzyme isoform X2

    Related
    ENSMUST00000219247.2
    Conserved Domains (1) summary
    cl19223
    Location:2 → 324
    G_glu_transpept; Gamma-glutamyltranspeptidase

  2. XM_006513647.4 → XP_006513710.1  glutathione hydrolase 5 proenzyme isoform X1

    Conserved Domains (1) summary
    cl19223
    Location:58 → 425
    G_glu_transpept; Gamma-glutamyltranspeptidase

  3. XM_036155784.1 → XP_036011677.1  glutathione hydrolase 5 proenzyme isoform X3

    Conserved Domains (1) summary
    cl19223
    Location:1 → 296
    G_glu_transpept; Gamma-glutamyltranspeptidase

RNA

  1. XR_001779525.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2A9.2 GenPept UniProtKB/Swiss-Prot:Q9Z2A9

Gene LinkOut

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