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Insrr insulin receptor-related receptor [ Mus musculus (house mouse) ]

Gene ID: 23920, updated on 4-Jan-2025

Summary

Official Symbol
Insrrprovided by MGI
Official Full Name
insulin receptor-related receptorprovided by MGI
Primary source
MGI:MGI:1346037
See related
Ensembl:ENSMUSG00000005640 AllianceGenome:MGI:1346037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irr
Summary
Predicted to enable insulin receptor activity and insulin receptor substrate binding activity. Involved in cellular response to alkaline pH and protein autophosphorylation. Acts upstream of or within male sex determination. Predicted to be located in membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in brain; early conceptus; ganglia; metanephros; and pancreas. Orthologous to human INSRR (insulin receptor related receptor). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in kidney adult (RPKM 10.4), colon adult (RPKM 3.5) and 9 other tissues See more
Orthologs
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Genomic context

See Insrr in Genome Data Viewer
Location:
3 F1; 3 38.7 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87704215..87723408)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87796908..87816101)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene neurotrophic tyrosine kinase, receptor, type 1 Neighboring gene predicted gene, 40086 Neighboring gene predicted gene, 32470

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables GPI-linked ephrin receptor activity  
enables boss receptor activity  
enables brain-derived neurotrophic factor receptor activity  
enables epidermal growth factor receptor activity  
enables fibroblast growth factor receptor activity  
enables hepatocyte growth factor receptor activity  
enables histone H2AXY142 kinase activity  
enables histone H3Y41 kinase activity  
enables insulin receptor activity  
enables insulin receptor activity  
enables insulin receptor substrate binding  
enables insulin receptor substrate binding  
enables insulin-like growth factor receptor activity  
enables macrophage colony-stimulating factor receptor activity  
enables phosphatidylinositol 3-kinase binding  
enables placental growth factor receptor activity  
enables platelet-derived growth factor alpha-receptor activity  
enables platelet-derived growth factor beta-receptor activity  
enables protein tyrosine kinase collagen receptor activity  
enables stem cell factor receptor activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane-ephrin receptor activity  
enables vascular endothelial growth factor receptor activity  
Process Evidence Code Pubs
involved_in Kit signaling pathway  
involved_in actin cytoskeleton organization  
involved_in actin cytoskeleton organization  
involved_in brain-derived neurotrophic factor receptor signaling pathway  
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
involved_in cellular response to alkaline pH PubMed 
involved_in cellular response to alkaline pH  
involved_in chromatin remodeling  
involved_in collagen-activated tyrosine kinase receptor signaling pathway  
involved_in ephrin receptor signaling pathway  
involved_in epidermal growth factor receptor signaling pathway  
involved_in fibroblast growth factor receptor signaling pathway  
involved_in hepatocyte growth factor receptor signaling pathway  
involved_in insulin receptor signaling pathway  
involved_in insulin-like growth factor receptor signaling pathway  
involved_in macrophage colony-stimulating factor signaling pathway  
acts_upstream_of_or_within male sex determination PubMed 
involved_in multicellular organism development  
involved_in platelet-derived growth factor receptor-alpha signaling pathway  
involved_in platelet-derived growth factor receptor-beta signaling pathway  
involved_in protein autophosphorylation PubMed 
involved_in protein autophosphorylation  
involved_in vascular endothelial growth factor receptor-1 signaling pathway  
involved_in vascular endothelial growth factor signaling pathway  
Component Evidence Code Pubs
is_active_in axon  
part_of insulin receptor complex  
located_in membrane  
is_active_in plasma membrane  
part_of receptor complex PubMed 

General protein information

Preferred Names
insulin receptor-related protein
Names
IR-related receptor
NP_035962.2
XP_006501514.1
XP_006501515.1
XP_006501516.1
XP_006501517.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011832.2NP_035962.2  insulin receptor-related protein precursor

    See identical proteins and their annotated locations for NP_035962.2

    Status: VALIDATED

    Source sequence(s)
    AB007135, AK142578
    Consensus CDS
    CCDS17454.1
    UniProtKB/Swiss-Prot
    B2RQC5, Q9WTL4
    Related
    ENSMUSP00000029711.3, ENSMUST00000029711.9
    Conserved Domains (6) summary
    cd05032
    Location:9721248
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:819908
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:228275
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:173326
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:346460
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:9791246
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87704215..87723408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501451.1XP_006501514.1  insulin receptor-related protein isoform X1

    Conserved Domains (4) summary
    cd05032
    Location:9721261
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:819908
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:173329
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:346459
    Recep_L_domain; Receptor L domain
  2. XM_006501454.1XP_006501517.1  insulin receptor-related protein isoform X4

    UniProtKB/TrEMBL
    Q3UQC8
    Conserved Domains (3) summary
    cd00063
    Location:819861
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:173329
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:346459
    Recep_L_domain; Receptor L domain
  3. XM_006501453.1XP_006501516.1  insulin receptor-related protein isoform X3

    UniProtKB/TrEMBL
    Q3UQC8
    Conserved Domains (3) summary
    cd00063
    Location:819858
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:173329
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:346459
    Recep_L_domain; Receptor L domain
  4. XM_006501452.3XP_006501515.1  insulin receptor-related protein isoform X2

    Conserved Domains (4) summary
    cd05032
    Location:8531142
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:700789
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00757
    Location:54210
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:227340
    Recep_L_domain; Receptor L domain
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