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Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein) [ Mus musculus (house mouse) ]

Gene ID: 24053, updated on 4-Jan-2025

Summary

Official Symbol
Sgcgprovided by MGI
Official Full Name
sarcoglycan, gamma (dystrophin-associated glycoprotein)provided by MGI
Primary source
MGI:MGI:1346524
See related
Ensembl:ENSMUSG00000035296 AllianceGenome:MGI:1346524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
35kDa; gamma-SG; 5430420E18Rik
Summary
Acts upstream of or within gene expression. Located in sarcolemma. Part of sarcoglycan complex. Is expressed in tongue; urinary system; and vertebral axis musculature. Used to study autosomal recessive limb-girdle muscular dystrophy type 2C and limb-girdle muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2C and type 2 diabetes mellitus. Orthologous to human SGCG (sarcoglycan gamma). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in heart adult (RPKM 37.1), mammary gland adult (RPKM 4.1) and 1 other tissue See more
Orthologs
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Genomic context

See Sgcg in Genome Data Viewer
Location:
14 D1; 14 32.27 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (61456555..61495939, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (61219106..61275062, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61665054-61665237 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61675420-61675649 Neighboring gene predicted gene, 41167 Neighboring gene predicted gene, 41168 Neighboring gene STARR-positive B cell enhancer ABC_E8562 Neighboring gene sacsin Neighboring gene predicted gene, 17778 Neighboring gene eukaryotic translation initiation factor 3, subunit E pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoskeleton  
part_of dystroglycan complex PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane PubMed 
part_of sarcoglycan complex  
part_of sarcoglycan complex PubMed 
is_active_in sarcolemma  
located_in sarcolemma PubMed 

General protein information

Preferred Names
gamma-sarcoglycan
Names
35 kDa dystrophin-associated glycoprotein
35DAG
sarcoglycan, gamma (35kD dystrophin-associated glycoprotein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011892.3NP_036022.1  gamma-sarcoglycan

    See identical proteins and their annotated locations for NP_036022.1

    Status: VALIDATED

    Source sequence(s)
    AC138718, AK132610
    Consensus CDS
    CCDS27181.1
    UniProtKB/Swiss-Prot
    P82348
    UniProtKB/TrEMBL
    Q9EQ83
    Related
    ENSMUSP00000077106.6, ENSMUST00000077954.13
    Conserved Domains (1) summary
    pfam04790
    Location:25278
    Sarcoglycan_1; Sarcoglycan complex subunit protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    61456555..61495939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158597.1XP_036014490.1  gamma-sarcoglycan isoform X1

    UniProtKB/Swiss-Prot
    P82348
    UniProtKB/TrEMBL
    Q9EQ83
    Related
    ENSMUSP00000112576.2, ENSMUST00000121148.8
    Conserved Domains (1) summary
    pfam04790
    Location:25278
    Sarcoglycan_1; Sarcoglycan complex subunit protein
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