U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lax1 lymphocyte transmembrane adaptor 1 [ Mus musculus (house mouse) ]

Gene ID: 240754, updated on 12-May-2024

Summary

Go to the top of the page Help
Official Symbol
Lax1provided by MGI
Official Full Name
lymphocyte transmembrane adaptor 1provided by MGI
Primary source
MGI:MGI:2443362
See related
Ensembl:ENSMUSG00000051998 AllianceGenome:MGI:2443362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A530029E09; E430019B13Rik
Summary
Predicted to enable SH2 domain binding activity and protein kinase binding activity. Acts upstream of or within antigen receptor-mediated signaling pathway and lymphocyte activation. Predicted to be located in Golgi apparatus and cytosol. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human LAX1 (lymphocyte transmembrane adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 14.6), thymus adult (RPKM 5.7) and 7 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Lax1 in Genome Data Viewer
Location:
1 E4; 1 57.95 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133606767..133620760, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133679017..133693022, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02294 Neighboring gene small nuclear ribonucleoprotein E Neighboring gene predicted gene, 53475 Neighboring gene zinc finger CCCH type containing 11A Neighboring gene zinc finger, BED type containing 6 Neighboring gene STARR-seq mESC enhancer starr_02296 Neighboring gene STARR-seq mESC enhancer starr_02297 Neighboring gene STARR-seq mESC enhancer starr_02298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135586656-135586812 Neighboring gene STARR-seq mESC enhancer starr_02299 Neighboring gene ATPase, Ca++ transporting, plasma membrane 4 Neighboring gene STARR-seq mESC enhancer starr_02301 Neighboring gene microRNA 6903 Neighboring gene STARR-seq mESC enhancer starr_02302 Neighboring gene predicted gene, 53476

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX. Zhu M, et al. J Biol Chem, 2006 Jul 7. PMID 16672218
  2. Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX. Arndt B, et al. J Leukoc Biol, 2013 Mar. PMID 23307938
  3. Negative regulation of lymphocyte activation by the adaptor protein LAX. Zhu M, et al. J Immunol, 2005 May 1. PMID 15843560
  4. Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. Zhu M, et al. J Biol Chem, 2002 Nov 29. PMID 12359715
  5. Molecular genetic analysis of two loci (Ity2 and Ity3) involved in the host response to infection with Salmonella typhimurium using congenic mice and expression profiling. Sancho-Shimizu V, et al. Genetics, 2007 Oct. PMID 17660555, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SIT and LAX are important negative regulators of immune responses that functionally cooperate.
    Title: Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX.
  2. Upon T or B cell activation, the LAX protein is up-regulated dramatically. This in vivo study of LAX-deficient mice demonstrates that LAX functions as a negative regulator in lymphocyte signaling.
    Title: Negative regulation of lymphocyte activation by the adaptor protein LAX.
  3. LAX negatively regulates mast cell function
    Title: Negative regulation of Fc epsilonRI-mediated signaling and mast cell function by the adaptor protein LAX.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in antigen receptor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen receptor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in lymphocyte activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lymphocyte activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lymphocyte activation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
lymphocyte transmembrane adapter 1
Names
linker for activation of X cells
membrane-associated adapter protein LAX

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159649.1 → NP_001153121.1  lymphocyte transmembrane adapter 1

    See identical proteins and their annotated locations for NP_001153121.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124338, AY090785
    Consensus CDS
    CCDS35711.1
    UniProtKB/Swiss-Prot
    Q8BHB3, Q8BS18, Q8CGV1
    Related
    ENSMUSP00000131126.2, ENSMUST00000169295.8
    Conserved Domains (1) summary
    pfam15681
    Location:28 → 356
    LAX; Lymphocyte activation family X

  2. NM_172842.3 → NP_766430.3  lymphocyte transmembrane adapter 1

    See identical proteins and their annotated locations for NP_766430.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124338, AY090785
    Consensus CDS
    CCDS35711.1
    UniProtKB/Swiss-Prot
    Q8BHB3, Q8BS18, Q8CGV1
    Conserved Domains (1) summary
    pfam15681
    Location:28 → 356
    LAX; Lymphocyte activation family X

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133606767..133620760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529557.5 → XP_006529620.1  lymphocyte transmembrane adapter 1 isoform X1

    See identical proteins and their annotated locations for XP_006529620.1

    UniProtKB/Swiss-Prot
    Q8BHB3, Q8BS18, Q8CGV1
    Conserved Domains (1) summary
    pfam15681
    Location:28 → 356
    LAX; Lymphocyte activation family X
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHB3.2 GenPept UniProtKB/Swiss-Prot:Q8BHB3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous