U.S. flag

An official website of the United States government

Asip agouti signaling protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 24152, updated on 4-Jan-2025

Summary

Official Symbol
Asipprovided by RGD
Official Full Name
agouti signaling proteinprovided by RGD
Primary source
RGD:2003
See related
AllianceGenome:RGD:2003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ASP
Summary
This gene is involved in hair pigmentation. In several strains (ACI, IS, LEA, LEC, NER, and WKAH) this gene encodes a functional protein while in others (BN, BUF, DON, F344, SD, SHR, TM, WKY, and WTC) it lacks a 19 nt indel and is non-protein coding. [provided by RefSeq, Apr 2015]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Asip in Genome Data Viewer
Location:
3q41
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (163933768..164021377)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (143473584..143561170)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (150492010..150579870)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 subunit beta Neighboring gene small nucleolar RNA SNORA44 Neighboring gene transfer RNA alanine (anticodon AGC) 28 Neighboring gene adenosylhomocysteinase Neighboring gene ribosomal protein L12, pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables melanocortin receptor binding  
enables melanocortin receptor binding  
enables neuropeptide hormone activity  
enables signaling receptor binding  
enables type 3 melanocortin receptor binding  
enables type 3 melanocortin receptor binding  
enables type 4 melanocortin receptor binding  
enables type 4 melanocortin receptor binding  
Process Evidence Code Pubs
involved_in adult feeding behavior  
acts_upstream_of_or_within adult feeding behavior  
involved_in biological_process  
involved_in epigenetic programming in the zygotic pronuclei  
acts_upstream_of_or_within epigenetic programming in the zygotic pronuclei  
acts_upstream_of_or_within epigenetic regulation of gene expression  
involved_in generation of precursor metabolites and energy  
acts_upstream_of_or_within generation of precursor metabolites and energy  
involved_in hormone-mediated signaling pathway  
involved_in melanin biosynthetic process  
acts_upstream_of_or_within melanin biosynthetic process  
involved_in melanin biosynthetic process  
involved_in melanin biosynthetic process  
involved_in melanosome organization  
involved_in melanosome organization  
acts_upstream_of_or_within melanosome organization  
involved_in melanosome transport  
acts_upstream_of_or_within melanosome transport  
acts_upstream_of_or_within pigmentation  
involved_in positive regulation of melanin biosynthetic process  
involved_in positive regulation of melanin biosynthetic process  
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  
located_in extracellular space  

General protein information

Preferred Names
agouti-signaling protein
Names
Agouti (coat color)
agouti switch protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052979.2NP_443211.1  agouti-signaling protein precursor

    See identical proteins and their annotated locations for NP_443211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the protein-coding allele.
    Source sequence(s)
    AB045587
    UniProtKB/Swiss-Prot
    Q99JA2
    UniProtKB/TrEMBL
    F1LQS7
    Conserved Domains (1) summary
    smart00792
    Location:6127
    Agouti; Agouti protein

RNA

  1. NR_131764.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) represents the pseudogene allele.
    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    163933768..164021377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.