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Ak2 adenylate kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24184, updated on 2-May-2024

Summary

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Official Symbol
Ak2provided by RGD
Official Full Name
adenylate kinase 2provided by RGD
Primary source
RGD:2077
See related
Ensembl:ENSRNOG00000000122 AllianceGenome:RGD:2077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables adenylate kinase activity. Contributes to nucleobase-containing compound kinase activity. Involved in several processes, including oxidative phosphorylation; purine nucleotide metabolic process; and response to thyroid hormone. Located in cytosol; mitochondrial intermembrane space; and nucleus. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 732.2), Kidney (RPKM 532.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ak2 in Genome Data Viewer
Location:
5q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (146609469..146649008)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (141308650..141364633)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (147185474..147204050)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 62 Neighboring gene antizyme inhibitor 2 Neighboring gene ring finger protein 7-like Neighboring gene uncharacterized LOC102551249 Neighboring gene ring finger protein 19B Neighboring gene transmembrane protein 54 Neighboring gene hippocalcin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dynamic expression of adenylate kinase 2 in the hippocampus of pilocarpine model rats. Peng X, et al. J Mol Neurosci, 2012 May. PMID 22246993
  2. Distinct behaviors of adenylate kinase and cytochrome c observed following induction of mitochondrial permeability transition by Ca(2+) in the absence of respiratory substrate. Yamamoto T, et al. J Bioenerg Biomembr, 2008 Dec. PMID 19139979
  3. Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Eimre M, et al. Biochim Biophys Acta, 2008 Jun. PMID 18423391
  4. Evidence of a new phosphoryl transfer system in nucleotide metabolism. Vannoni D, et al. FEBS J, 2009 Jan. PMID 19049516
  5. Adenosine triphosphate-adenosine-5'-monophosphate phosphotransferase from normal human liver mitochondria. Isolation, chemical properties, and immunochemical comparison with Duchenne dystrophic serum aberrant adenylate kinase. Hamada M, et al. J Biol Chem, 1982 Nov 10. PMID 6182143

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AK2 participates in the pathophysiological process of temporal lobe epilepsy.
    Title: Dynamic expression of adenylate kinase 2 in the hippocampus of pilocarpine model rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables adenylate kinase activity TAS
Traceable Author Statement
more info
 PubMed 
contributes_to nucleobase-containing compound kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleobase-containing compound kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ADP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ADP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in AMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in AMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in adenine metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in dATP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in oxidative phosphorylation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to thyroid hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm mitochondrial sheath ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenylate kinase 2, mitochondrial
Names
AK 2
ATP-AMP transphosphorylase 2
ATP:AMP phosphotransferase
adenylate monophosphate kinase
NP_001029139.1
NP_112248.2
XP_038965181.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033967.2 → NP_001029139.1  adenylate kinase 2, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001029139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    BC061727, CO570724
    UniProtKB/Swiss-Prot
    P29410, Q6P7C6
    UniProtKB/TrEMBL
    A0A0G2JSG6, A6ISG7
    Related
    ENSRNOP00000000134.2, ENSRNOT00000000134.5
    Conserved Domains (2) summary
    PRK00279
    Location:17 → 229
    adk; adenylate kinase; Reviewed
    cd01428
    Location:17 → 219
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

  2. NM_030986.2 → NP_112248.2  adenylate kinase 2, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_112248.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform a).
    Source sequence(s)
    AA956036, CO570724
    UniProtKB/Swiss-Prot
    P29410, Q6P7C6
    UniProtKB/TrEMBL
    A6ISG8
    Conserved Domains (2) summary
    PRK00279
    Location:17 → 229
    adk; adenylate kinase; Reviewed
    cd01428
    Location:17 → 219
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    146609469..146649008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109253.2 → XP_038965181.1  adenylate kinase 2, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK00279
    Location:1 → 181
    adk; adenylate kinase; Reviewed
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29410.2 GenPept UniProtKB/Swiss-Prot:P29410

Gene LinkOut

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