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Alb albumin [ Rattus norvegicus (Norway rat) ]

Gene ID: 24186, updated on 4-Jan-2025

Summary

Official Symbol
Albprovided by RGD
Official Full Name
albuminprovided by RGD
Primary source
RGD:2085
See related
EnsemblRapid:ENSRNOG00000002911 AllianceGenome:RGD:2085
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Alb1; Albza
Summary
Enables several functions, including fatty acid binding activity; modified amino acid binding activity; and zinc ion binding activity. Involved in several processes, including positive regulation of circadian sleep/wake cycle, non-REM sleep; response to biphenyl; and response to platinum ion. Located in basement membrane and extracellular space. Used to study familial hyperlipidemia. Biomarker of Reye syndrome; obstructive jaundice; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including blood protein disease; hepatobiliary system cancer (multiple); hyperthyroxinemia; middle cerebral artery infarction; and psoriasis. Orthologous to human ALB (albumin). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 349119.2) See more
Orthologs
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Genomic context

See Alb in Genome Data Viewer
Location:
14p22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (17891564..17907043, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (17607397..17622814, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (19176275..19191793, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481728 Neighboring gene alpha-fetoprotein Neighboring gene ribosomal protein L8, pseudogene 4 Neighboring gene ankyrin repeat domain 17 Neighboring gene uncharacterized LOC134481729

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 32
Function Evidence Code Pubs
enables DNA binding  
enables DNA binding  
enables DNA binding  
enables enterobactin binding  
enables enterobactin binding  
enables enterobactin binding  
enables enterobactin binding  
enables enzyme binding PubMed 
enables exogenous protein binding  
enables exogenous protein binding  
enables fatty acid binding PubMed 
enables fatty acid binding  
enables fatty acid binding  
enables fatty acid binding  
enables identical protein binding  
enables identical protein binding  
enables lipid binding  
enables metal ion binding  
enables modified amino acid binding PubMed 
enables oxygen binding  
contributes_to oxygen binding  
contributes_to oxygen binding  
enables protein-folding chaperone binding  
enables protein-folding chaperone binding  
enables pyridoxal phosphate binding  
enables pyridoxal phosphate binding  
enables pyridoxal phosphate binding  
enables small molecule binding  
enables toxic substance binding  
enables toxic substance binding  
enables toxic substance binding  
enables zinc ion binding PubMed 
Items 1 - 25 of 32
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi apparatus  
located_in basement membrane PubMed 
is_active_in cytoplasm  
located_in cytoplasm  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in extracellular exosome  
located_in extracellular exosome  
located_in extracellular region  
located_in extracellular space PubMed 
located_in extracellular space  
located_in extracellular space  
part_of protein-containing complex  
part_of protein-containing complex  
part_of protein-containing complex  

General protein information

Preferred Names
albumin
Names
serum albumin
NP_599153.2
XP_063128922.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134326.2NP_599153.2  albumin precursor

    See identical proteins and their annotated locations for NP_599153.2

    Status: PROVISIONAL

    Source sequence(s)
    BC085359
    UniProtKB/Swiss-Prot
    P02770, P11382, Q5U3X3
    UniProtKB/TrEMBL
    A0A0G2JSH5
    Related
    ENSRNOP00000003921.3, ENSRNOT00000003921.6
    Conserved Domains (1) summary
    smart00103
    Location:21204
    ALBUMIN; serum albumin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    17891564..17907043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272852.1XP_063128922.1  albumin isoform X1

    UniProtKB/Swiss-Prot
    P02770, P11382, Q5U3X3
    UniProtKB/TrEMBL
    A0A0G2JSH5
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