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Calca calcitonin-related polypeptide alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 24241, updated on 4-Jan-2025

Summary

Official Symbol
Calcaprovided by RGD
Official Full Name
calcitonin-related polypeptide alphaprovided by RGD
Primary source
RGD:2254
See related
EnsemblRapid:ENSRNOG00000011130 AllianceGenome:RGD:2254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CAL6; CGRP; Cal1; Calc; CGRP1; RATCAL6; calcitonin
Summary
Predicted to enable calcitonin receptor binding activity; hormone activity; and identical protein binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; cellular response to tumor necrosis factor; and vasodilation. Located in axon; extracellular space; and neuronal cell body. Is active in hippocampal mossy fiber to CA3 synapse and neuronal dense core vesicle. Used to study acute necrotizing pancreatitis; ischemia; and stomach disease. Biomarker of middle cerebral artery infarction; migraine; prediabetes syndrome; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in migraine and osteoporosis. Orthologous to human CALCA (calcitonin related polypeptide alpha). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Uterus (RPKM 51.7), Brain (RPKM 7.1) and 2 other tissues See more
Orthologs
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Genomic context

See Calca in Genome Data Viewer
Location:
1q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (178312636..178317588, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (168878212..168883176, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (184184018..184188922, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-like protein FUBI-like Neighboring gene phosphodiesterase 3B Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1 Neighboring gene calcitonin-related polypeptide, beta Neighboring gene INSC, spindle orientation adaptor protein Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcitonin receptor binding  
enables calcitonin receptor binding  
enables calcitonin receptor binding PubMed 
enables hormone activity  
enables hormone activity  
enables identical protein binding  
enables neuropeptide hormone activity PubMed 
enables protein-containing complex binding  
enables signaling receptor binding  
Items 1 - 25 of 56
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization  
acts_upstream_of_or_within activation of adenylate cyclase activity  
involved_in activation of adenylate cyclase activity  
involved_in activation of protein kinase activity  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in amylin receptor 1 signaling pathway  
involved_in amylin receptor 2 signaling pathway  
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
acts_upstream_of_or_within artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure  
involved_in calcitonin family receptor signaling pathway  
involved_in calcitonin gene-related peptide receptor signaling pathway  
acts_upstream_of cell adhesion  
involved_in cellular response to nerve growth factor stimulus PubMed 
acts_upstream_of_or_within cellular response to nerve growth factor stimulus  
involved_in cellular response to tumor necrosis factor PubMed 
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain  
involved_in embryo implantation  
involved_in endothelial cell migration  
involved_in endothelial cell proliferation  
acts_upstream_of_or_within feeding behavior  
acts_upstream_of_or_within inflammatory response  
involved_in innate immune response  
acts_upstream_of_or_within intracellular calcium ion homeostasis  
involved_in leukocyte cell-cell adhesion  
involved_in monocyte chemotaxis  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of blood pressure PubMed 
acts_upstream_of_or_within negative regulation of blood pressure  
involved_in negative regulation of bone resorption  
involved_in negative regulation of calcium ion transport into cytosol  
acts_upstream_of_or_within negative regulation of ossification  
involved_in negative regulation of osteoclast differentiation  
involved_in negative regulation of smooth muscle contraction PubMed 
acts_upstream_of_or_within negative regulation of smooth muscle contraction  
acts_upstream_of_or_within nervous system process involved in regulation of systemic arterial blood pressure  
acts_upstream_of_or_within neuropeptide signaling pathway  
acts_upstream_of ossification  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within positive regulation of cell adhesion  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of interleukin-1 alpha production  
involved_in positive regulation of interleukin-8 production  
involved_in positive regulation of macrophage differentiation  
involved_in protein phosphorylation  
involved_in receptor internalization  
involved_in regulation of cytosolic calcium ion concentration  
involved_in regulation of cytosolic calcium ion concentration  
acts_upstream_of_or_within response to heat  
acts_upstream_of_or_within response to pain  
involved_in signal transduction  
acts_upstream_of smooth muscle contraction  
involved_in vasculature development  
involved_in vasodilation PubMed 
involved_in vasodilation  
Items 1 - 25 of 56
Component Evidence Code Pubs
located_in axon PubMed 
located_in axon  
located_in cytoplasm  
located_in extracellular region  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
is_active_in extracellular space  
located_in extracellular space  
is_active_in hippocampal mossy fiber to CA3 synapse PubMed 
located_in neuron projection  
located_in neuronal cell body PubMed 
is_active_in neuronal dense core vesicle PubMed 
located_in terminal bouton  

General protein information

Preferred Names
calcitonin gene-related peptide 1
Names
CGRP-I
alpha-type CGRP
calcitonin gene-related peptide I
calcitonin/calcitonin-related polypeptide, alpha
procalcitonin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033955.1NP_001029127.1  calcitonin gene-related peptide 1 isoform Cgrp preproprotein

    See identical proteins and their annotated locations for NP_001029127.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (Cgrp) has a shorter and distinct C-terminus compared to isoform Calca.
    Source sequence(s)
    AW523601, BG663259, CB711853, CB746609, CF978038
    UniProtKB/Swiss-Prot
    P01256
    UniProtKB/TrEMBL
    A0A0G2JSX2, A6I8B3
    Related
    ENSRNOP00000051997.2, ENSRNOT00000055124.6
    Conserved Domains (1) summary
    pfam00214
    Location:1124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  2. NM_001033956.1NP_001029128.1  calcitonin gene-related peptide 1 isoform Cgrp preproprotein

    See identical proteins and their annotated locations for NP_001029128.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding sequence compared to variant 1. The resulting isoform (Cgrp) has a shorter and distinct C-terminus compared to isoform Calca.
    Source sequence(s)
    AW523601, BG663259, CB746609, CF978038
    UniProtKB/Swiss-Prot
    P01256
    UniProtKB/TrEMBL
    A0A0G2JSX2, A6I8B3
    Conserved Domains (1) summary
    pfam00214
    Location:1124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  3. NM_017338.2NP_059034.1  calcitonin gene-related peptide 1 isoform Calca preproprotein

    See identical proteins and their annotated locations for NP_059034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (Calca).
    Source sequence(s)
    BG663259, CF978038, V01228
    UniProtKB/Swiss-Prot
    P01257
    UniProtKB/TrEMBL
    A6I8B8
    Related
    ENSRNOP00000014948.2, ENSRNOT00000014948.7
    Conserved Domains (1) summary
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    178312636..178317588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759676.4XP_008757898.1  calcitonin gene-related peptide 1 isoform X1

    See identical proteins and their annotated locations for XP_008757898.1

    UniProtKB/Swiss-Prot
    P01257
    UniProtKB/TrEMBL
    A6I8B8
    Conserved Domains (1) summary
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
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