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Myom3 myomesin family, member 3 [ Mus musculus (house mouse) ]

Gene ID: 242702, updated on 9-May-2024

Summary

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Official Symbol
Myom3provided by MGI
Official Full Name
myomesin family, member 3provided by MGI
Primary source
MGI:MGI:2685280
See related
Ensembl:ENSMUSG00000037139 AllianceGenome:MGI:2685280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm434; 8430427K15Rik
Summary
Enables protein homodimerization activity. Predicted to be involved in muscle contraction. Located in M band. Is expressed in diaphragm; leg; skeletal musculature; and somite. Orthologous to human MYOM3 (myomesin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 2.0), placenta adult (RPKM 0.8) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 68.0 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135486688..135542882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135758800..135815571)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene interleukin 22 receptor, alpha 1 Neighboring gene S-phase kinase-associated protein 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_11736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135411492-135411675 Neighboring gene STARR-positive B cell enhancer ABC_E7999 Neighboring gene serine and arginine-rich splicing factor 10 Neighboring gene STARR-positive B cell enhancer ABC_E4683 Neighboring gene proline-rich nuclear receptor coactivator 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sarcosin (Krp1) in skeletal muscle differentiation: gene expression profiling and knockdown experiments. du Puy L, et al. Int J Dev Biol, 2012. PMID 22562206
  2. Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies. Rouillon J, et al. Hum Mol Genet, 2015 Sep 1. PMID 26060189, Free PMC Article
  3. Myomesin 3, a novel structural component of the M-band in striated muscle. Schoenauer R, et al. J Mol Biol, 2008 Feb 15. PMID 18177667
  4. CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. Beqqali A, et al. J Cell Sci, 2010 Apr 1. PMID 20215401
  5. The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis. Gómez-Del Arco P, et al. Cell Metab, 2016 May 10. PMID 27166947

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYOM3 fragments hold promise for minimally invasive assessment of experimental therapies for DMD and other neuromuscular disorders.
    Title: Serum proteomic profiling reveals fragments of MYOM3 as potential biomarkers for monitoring the outcome of therapeutic interventions in muscular dystrophies.
  2. Myomesin 3, a novel structural component of the M-band in striated muscle.
    Title: Myomesin 3, a novel structural component of the M-band in striated muscle.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in M band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myomesin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085509.2 → NP_001078978.1  myomesin-3

    See identical proteins and their annotated locations for NP_001078978.1

    Status: VALIDATED

    Source sequence(s)
    AL662911
    Consensus CDS
    CCDS38921.1
    UniProtKB/Swiss-Prot
    A2ABU4
    Related
    ENSMUSP00000101480.2, ENSMUST00000105854.2
    Conserved Domains (5) summary
    cd00096
    Location:171 → 244
    Ig; Immunoglobulin domain
    smart00410
    Location:1137 → 1207
    IG_like; Immunoglobulin like
    cd00063
    Location:804 → 893
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:1343 → 1426
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:1336 → 1426
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135486688..135542882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320223.3 → XP_017175712.1  myomesin-3 isoform X1

    Conserved Domains (3) summary
    cd00063
    Location:804 → 893
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:154 → 247
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:272 → 363
    Ig; Immunoglobulin domain

  2. XM_017320224.2 → XP_017175713.1  myomesin-3 isoform X2

    Conserved Domains (3) summary
    cd00063
    Location:221 → 310
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:555 → 619
    Ig; Immunoglobulin domain
    cl11960
    Location:753 → 843
    Ig; Immunoglobulin domain

RNA

  1. XR_003954947.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2ABU4.1 GenPept UniProtKB/Swiss-Prot:A2ABU4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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