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Cryge crystallin, gamma E [ Rattus norvegicus (Norway rat) ]

Gene ID: 24279, updated on 29-Feb-2024

Summary

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Symbol
Crygeprovided by RGD
Full Name
crystallin, gamma Eprovided by RGD
Primary source
RGD:2423
See related
AllianceGenome:RGD:2423
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Len; Cryg5
Summary
Predicted to be a structural constituent of eye lens. Involved in lens development in camera-type eye. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Cryge in Genome Data Viewer
Location:
9q32
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (73923661..73926258, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (66429924..66432521, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71764317..71767045, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene basic proline-rich protein-like Neighboring gene frizzled class receptor 5 Neighboring gene pleckstrin homology domain containing M3 Neighboring gene uncharacterized LOC120094696 Neighboring gene uncharacterized LOC102552040 Neighboring gene crystallin, gamma D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Strict co-linearity of genetic and protein folding domains in an intragenically duplicated rat lens gamma-crystallin gene. Moormann RJ, et al. J Mol Biol, 1983 Dec 25. PMID 6319707
  2. Consensus sequences of the Rattus norvegicus B1- and B2 repeats. den Dunnen JT, et al. Nucleic Acids Res, 1987 Mar 25. PMID 3562235, Free PMC Article
  3. Site specific oxidation of amino acid residues in rat lens γ-crystallin induced by low-dose γ-irradiation. Kim I, et al. Biochem Biophys Res Commun, 2015 Oct 30. PMID 26385181
  4. Towards a molecular understanding of phase separation in the lens: a comparison of the X-ray structures of two high Tc gamma-crystallins, gammaE and gammaF, with two low Tc gamma-crystallins, gammaB and gammaD. Norledge BV, et al. Exp Eye Res, 1997 Nov. PMID 9367641
  5. Extensive intragenic sequence homology in two distinct rat lens gamma-crystallin cDNAs suggests duplications of a primordial gene. Moormann RJ, et al. Proc Natl Acad Sci U S A, 1982 Nov. PMID 6294661, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of eye lens IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of eye lens TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in lens development in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lens development in camera-type eye IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-crystallin E
Names
Crystallin, gamma polypeptide 5
gamma-2
gamma-E-crystallin
gamma-crystallin 3-1
gamma-crystallin D-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173289.1 → NP_775411.1  gamma-crystallin E

    See identical proteins and their annotated locations for NP_775411.1

    Status: PROVISIONAL

    Source sequence(s)
    M19359
    UniProtKB/Swiss-Prot
    P02528
    UniProtKB/TrEMBL
    D3ZR45
    Conserved Domains (2) summary
    smart00247
    Location:3 → 82
    XTALbg; Beta/gamma crystallins
    pfam00030
    Location:89 → 170
    Crystall; Beta/Gamma crystallin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    73923661..73926258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02528.2 GenPept UniProtKB/Swiss-Prot:P02528

Gene LinkOut

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