Foxg1 forkhead box G1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Foxg1provided by RGD
Official Full Name: forkhead box G1provided by RGD
Primary source: RGD:2619
See related: Ensembl:ENSRNOG00000047891 AllianceGenome:RGD:2619
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BF1A; Fkhl1; RATBF1A
Summary: Predicted to enable sequence-specific double-stranded DNA binding activity. Involved in aging and brain development. Predicted to be active in nucleus. Orthologous to human FOXG1 (forkhead box G1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 6q22

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (72401582..72404392)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (66674797..66677611)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (69971227..69974037)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways.
Title: The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways.
TLE1 cooperates with FoxG1 to promote neuronal survival in a CK2- and PI3K-Akt-dependent manner.
Title: Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival.
The antioxidant Trolox attenuates mechanical ventilation-induced diaphragmatic atrophy independent of alterations in Akt regulation of FoxO transcription factors and expression of MAFbx or MuRF-1.
Title: Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling.
FoxG1 may interact with AR in vivo, thereby targeting its repressor function specifically to sex hormone signaling.
Title: FoxG1, a member of the forkhead family, is a corepressor of the androgen receptor.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Foxg1 (e-PCR), detects polymorphism
- UniSTS:530688

Foxg1 (e-PCR), detects polymorphism
- UniSTS:164909

Foxg1 (e-PCR), detects polymorphism
- UniSTS:515965

UniSTS:225243 (e-PCR)
- UniSTS:225243

Foxg1 (e-PCR), detects polymorphism
- UniSTS:527351

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon midline choice point recognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pyramidal neuron migration to cerebral cortex	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein G1

Names: BF-1; BF1; brain factor 1; forkhead-like transcription factor BF-1; forkhead-related protein FKHL1; transcription factor BF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012560.4 → NP_036692.1 forkhead box protein G1

See identical proteins and their annotated locations for NP_036692.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q00939

UniProtKB/TrEMBL

A6HBG0

Related

ENSRNOP00000067118.1, ENSRNOT00000075349.2

Conserved Domains (2) summary

COG5025
Location:175 → 347

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

cd20021
Location:172 → 250

FH_FOXG; Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily