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Gp6 glycoprotein 6 platelet [ Mus musculus (house mouse) ]

Gene ID: 243816, updated on 13-Jan-2025

Summary

Official Symbol
Gp6provided by MGI
Official Full Name
glycoprotein 6 plateletprovided by MGI
Primary source
MGI:MGI:1889810
See related
Ensembl:ENSMUSG00000078810 AllianceGenome:MGI:1889810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpvi; Gm469; 9830166G18Rik
Summary
Enables collagen binding activity and collagen receptor activity. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway; peptidyl-tyrosine phosphorylation; and platelet aggregation. Located in cell surface and plasma membrane. Is expressed in bone marrow; femur; liver; and spleen. Human ortholog(s) of this gene implicated in blood platelet disease (multiple); coronary artery disease (multiple); and type 2 diabetes mellitus. Orthologous to human GP6 (glycoprotein VI platelet). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Gp6 in Genome Data Viewer
Location:
7 A1; 7 2.52 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4365852..4400849, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4362853..4397851, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15931 Neighboring gene STARR-seq mESC enhancer starr_17925 Neighboring gene STARR-seq mESC enhancer starr_17927 Neighboring gene STARR-seq mESC enhancer starr_17928 Neighboring gene STARR-seq mESC enhancer starr_17929 Neighboring gene STARR-seq mESC enhancer starr_17930 Neighboring gene natural cytotoxicity triggering receptor 1 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E1718 Neighboring gene STARR-positive B cell enhancer ABC_E9682 Neighboring gene retinol dehydrogenase 13 (all-trans and 9-cis) Neighboring gene RIKEN cDNA D630041G03 gene Neighboring gene EPS8-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cell surface PubMed 
located_in membrane raft  
is_active_in membrane raft  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in tetraspanin-enriched microdomain  
located_in tetraspanin-enriched microdomain  

General protein information

Preferred Names
platelet glycoprotein VI
Names
glycoprotein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163014.1NP_001156486.1  platelet glycoprotein VI precursor

    See identical proteins and their annotated locations for NP_001156486.1

    Status: VALIDATED

    Source sequence(s)
    AC137969
    Consensus CDS
    CCDS51972.1
    UniProtKB/Swiss-Prot
    E9QPN2, P0C191
    UniProtKB/TrEMBL
    B2RR15
    Related
    ENSMUSP00000145740.2, ENSMUST00000206928.2
    Conserved Domains (2) summary
    smart00410
    Location:3496
    IG_like; Immunoglobulin like
    cl11960
    Location:27109
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4365852..4400849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539910.4XP_006539973.1  platelet glycoprotein VI isoform X2

    Conserved Domains (1) summary
    cl11960
    Location:16105
    Ig; Immunoglobulin domain
  2. XM_006539909.4XP_006539972.1  platelet glycoprotein VI isoform X1

    UniProtKB/TrEMBL
    A0A140T8Q7
    Conserved Domains (1) summary
    cl11960
    Location:114203
    Ig; Immunoglobulin domain
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