Gp6 glycoprotein 6 platelet [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gp6provided by MGI
Official Full Name: glycoprotein 6 plateletprovided by MGI
Primary source: MGI:MGI:1889810
See related: Ensembl:ENSMUSG00000078810 AllianceGenome:MGI:1889810
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpvi; Gm469; 9830166G18Rik
Summary: Enables collagen binding activity and collagen receptor activity. Involved in vasculature development. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway. Is integral component of plasma membrane. Is expressed in bone marrow; femur; liver; and spleen. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 11. Orthologous to human GP6 (glycoprotein VI platelet). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.52 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4365852..4400849, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4362853..4397851, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction.
Title: Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction.
A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury.
Title: A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury.
Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography.
Title: Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography.
Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability.
Title: Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability.
The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of beta-amyloid.
Title: The collagen receptor glycoprotein VI promotes platelet-mediated aggregation of β-amyloid.
Platelet glycoprotein VI-dependent thrombus stabilization is essential for the intraportal engraftment of pancreatic islets.
Title: Platelet glycoprotein VI-dependent thrombus stabilization is essential for the intraportal engraftment of pancreatic islets.
Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3.
Title: Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3.
Our results show that, contrary to defects in coagulation, bleeding following a loss of vascular integrity caused by platelet CLEC-2 and GPVI deficiency facilitates wound repair by increasing fibrin(ogen) deposition, reducing inflammation, and promoting angiogenesis.
Title: Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice.
the truncated CD45 isoform regulates GPVI-mediated signaling and platelet functional responses by regulating SFK activation
Title: Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice.
GPVI and alpha2beta1 have no influence on the localization of megakaryocytes within the bone marrow, their association to the sinusoids or their maturation
Title: Impact of Itga2-Gp6-double collagen receptor deficient mice for bone marrow megakaryocytes and platelets.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

General gene information

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Markers

Gp6 (e-PCR), detects polymorphism
- UniSTS:528183

Gp6 (e-PCR), detects polymorphism
- UniSTS:186224

NoName (e-PCR)
- UniSTS:494280

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables collagen receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within platelet aggregation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in tetraspanin-enriched microdomain	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: platelet glycoprotein VI

Names: glycoprotein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163014.1 → NP_001156486.1 platelet glycoprotein VI precursor

See identical proteins and their annotated locations for NP_001156486.1

Status: VALIDATED

Source sequence(s)

AC137969

Consensus CDS

CCDS51972.1

UniProtKB/Swiss-Prot

E9QPN2, P0C191

UniProtKB/TrEMBL

B2RR15

Related

ENSMUSP00000145740.2, ENSMUST00000206928.2

Conserved Domains (2) summary

smart00410
Location:34 → 96

IG_like; Immunoglobulin like

cl11960
Location:27 → 109

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

4365852..4400849 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539910.4 → XP_006539973.1 platelet glycoprotein VI isoform X2

Conserved Domains (1) summary

cl11960
Location:16 → 105

Ig; Immunoglobulin domain
XM_006539909.4 → XP_006539972.1 platelet glycoprotein VI isoform X1

UniProtKB/TrEMBL

A0A140T8Q7

Conserved Domains (1) summary

cl11960
Location:114 → 203

Ig; Immunoglobulin domain