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Zfp324 zinc finger protein 324 [ Mus musculus (house mouse) ]

Gene ID: 243834, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp324provided by MGI
Official Full Name
zinc finger protein 324provided by MGI
Primary source
MGI:MGI:2444641
See related
Ensembl:ENSMUSG00000004500 AllianceGenome:MGI:2444641
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZF5128; A930002M05; D430030K24Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in 1st branchial arch maxillary component; early conceptus; genitourinary system; and heart. Orthologous to several human genes including ZNF324 (zinc finger protein 324). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 6.1), adrenal adult (RPKM 3.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp324 in Genome Data Viewer
Location:
7 A1; 7 7.71 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12699765..12707749)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12965838..12974244)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 225 Neighboring gene predicted gene, 26325 Neighboring gene RIKEN cDNA 1810019N24 gene Neighboring gene STARR-seq mESC enhancer starr_18063 Neighboring gene predicted gene 29638 Neighboring gene zinc finger protein 446 Neighboring gene solute carrier family 27 (fatty acid transporter), member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 324A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362139.1 → NP_001349068.1  zinc finger protein 324A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK054407, AK152107, BC053093
    UniProtKB/TrEMBL
    Q8BW39
    Conserved Domains (3) summary
    COG5048
    Location:69 → 269
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:65 → 85
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:274 → 297
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001362140.1 → NP_001349069.1  zinc finger protein 324A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK052251, AK054407, AK152107, BC053093
    UniProtKB/TrEMBL
    Q8BW39
    Conserved Domains (3) summary
    COG5048
    Location:69 → 269
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:65 → 85
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:274 → 297
    zf-H2C2_2; Zinc-finger double domain

  3. NM_178732.4 → NP_848847.3  zinc finger protein 324A isoform 1

    See identical proteins and their annotated locations for NP_848847.3

    Status: VALIDATED

    Source sequence(s)
    AK152107, BC053093
    Consensus CDS
    CCDS20819.1
    UniProtKB/TrEMBL
    Q78F42
    Related
    ENSMUSP00000041944.8, ENSMUST00000038701.8
    Conserved Domains (6) summary
    smart00349
    Location:31 → 91
    KRAB; krueppel associated box
    COG5048
    Location:297 → 497
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293 → 313
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:31 → 70
    KRAB; KRAB box
    pfam13465
    Location:305 → 330
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    12699765..12707749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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