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Grin2a glutamate ionotropic receptor NMDA type subunit 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24409, updated on 4-Jan-2025

Summary

Official Symbol
Grin2aprovided by RGD
Official Full Name
glutamate ionotropic receptor NMDA type subunit 2Aprovided by RGD
Primary source
RGD:2737
See related
EnsemblRapid:ENSRNOG00000033942 AllianceGenome:RGD:2737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
NR2A; GluN2A; NMDAR2A
Summary
Enables several functions, including enzyme binding activity; glutamate binding activity; and monoatomic ion channel activity. Contributes to extracellularly glutamate-gated ion channel activity and monoatomic cation channel activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of signal transduction. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic membrane. Used to study hyperhomocysteinemia and transient cerebral ischemia. Biomarker of cognitive disorder; placental insufficiency; post-traumatic stress disorder; status epilepticus; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; bipolar disorder; colorectal cancer; and heroin dependence. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 176.8) See more
Orthologs
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Genomic context

See Grin2a in Genome Data Viewer
Location:
10q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (6136458..6560003)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (5629683..6053262)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (5707806..6123568)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 like 1 Neighboring gene uncharacterized LOC108352053 Neighboring gene uncharacterized LOC120095022 Neighboring gene uncharacterized LOC134480648 Neighboring gene similar to 60S ribosomal protein L23a

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 40
Function Evidence Code Pubs
enables ATPase binding PubMed 
enables NMDA glutamate receptor activity PubMed 
enables NMDA glutamate receptor activity  
enables NMDA glutamate receptor activity PubMed 
contributes_to NMDA glutamate receptor activity  
enables NMDA glutamate receptor activity  
contributes_to calcium channel activity  
enables calcium channel activity  
enables calcium-dependent protein binding PubMed 
enables cell adhesion molecule binding PubMed 
contributes_to extracellularly glutamate-gated ion channel activity PubMed 
enables glutamate binding PubMed 
enables glutamate binding PubMed 
enables glutamate receptor activity  
enables glutamate receptor binding PubMed 
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated receptor activity PubMed 
contributes_to glutamate-gated receptor activity PubMed 
enables glutamate-gated receptor activity PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential PubMed 
enables metal ion binding  
contributes_to monoatomic cation channel activity PubMed 
enables monoatomic cation channel activity  
enables protein binding PubMed 
enables protein kinase binding PubMed 
enables protein tyrosine kinase binding PubMed 
enables protein-containing complex binding PubMed 
enables protein-containing complex binding PubMed 
enables scaffold protein binding PubMed 
enables signaling receptor binding PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables voltage-gated monoatomic cation channel activity PubMed 
enables zinc ion binding PubMed 
enables zinc ion binding  
Items 1 - 25 of 40
Items 1 - 25 of 129
Process Evidence Code Pubs
involved_in action potential PubMed 
involved_in auditory behavior PubMed 
involved_in calcium ion transmembrane import into cytosol  
involved_in calcium ion transmembrane import into cytosol  
involved_in calcium ion transmembrane import into cytosol  
involved_in calcium ion transmembrane transport  
acts_upstream_of_or_within calcium ion transport  
involved_in calcium-mediated signaling  
involved_in cellular response to amino acid stimulus PubMed 
NOT involved_in cellular response to amyloid-beta  
involved_in cellular response to dsRNA PubMed 
involved_in cellular response to glycine PubMed 
involved_in cellular response to growth factor stimulus PubMed 
involved_in cellular response to lipid PubMed 
involved_in cellular response to magnesium ion PubMed 
involved_in cellular response to manganese ion PubMed 
involved_in cellular response to zinc ion PubMed 
involved_in cerebral cortex development PubMed 
involved_in chemical synaptic transmission PubMed 
acts_upstream_of_or_within chemical synaptic transmission  
involved_in conditioned place preference PubMed 
involved_in dendritic spine organization PubMed 
NOT acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain  
involved_in directional locomotion  
acts_upstream_of_or_within directional locomotion  
involved_in dopamine metabolic process  
acts_upstream_of_or_within dopamine metabolic process  
involved_in excitatory postsynaptic potential  
involved_in excitatory postsynaptic potential  
involved_in excitatory postsynaptic potential PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential  
involved_in glutamate receptor signaling pathway  
involved_in hippocampus development PubMed 
involved_in ionotropic glutamate receptor signaling pathway PubMed 
involved_in ionotropic glutamate receptor signaling pathway  
involved_in ionotropic glutamate receptor signaling pathway  
acts_upstream_of_or_within learning  
acts_upstream_of_or_within learning or memory  
acts_upstream_of_or_within locomotion  
involved_in long-term synaptic potentiation  
involved_in long-term synaptic potentiation  
involved_in long-term synaptic potentiation PubMed 
acts_upstream_of_or_within long-term synaptic potentiation  
involved_in memory PubMed 
involved_in memory  
acts_upstream_of_or_within memory  
involved_in modulation of chemical synaptic transmission  
involved_in modulation of excitatory postsynaptic potential PubMed 
involved_in monoatomic cation transmembrane transport PubMed 
involved_in monoatomic cation transmembrane transport  
involved_in monoatomic cation transmembrane transport  
involved_in multicellular organismal response to stress PubMed 
involved_in negative regulation of protein catabolic process  
acts_upstream_of_or_within negative regulation of protein catabolic process  
involved_in neurogenesis  
acts_upstream_of_or_within neurogenesis  
involved_in neuron development PubMed 
involved_in neurotransmitter receptor transport, plasma membrane to endosome PubMed 
involved_in positive regulation of apoptotic process  
acts_upstream_of_or_within positive regulation of apoptotic process  
involved_in positive regulation of excitatory postsynaptic potential PubMed 
involved_in positive regulation of excitatory postsynaptic potential PubMed 
involved_in positive regulation of excitatory postsynaptic potential  
involved_in positive regulation of inhibitory postsynaptic potential PubMed 
involved_in positive regulation of protein targeting to membrane PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic  
involved_in protein catabolic process  
acts_upstream_of protein catabolic process  
involved_in protein localization to postsynaptic membrane  
acts_upstream_of_or_within protein localization to postsynaptic membrane  
involved_in receptor recycling PubMed 
involved_in regulation of ARF protein signal transduction PubMed 
involved_in regulation of NMDA receptor activity PubMed 
involved_in regulation of long-term neuronal synaptic plasticity PubMed 
involved_in regulation of membrane potential PubMed 
acts_upstream_of_or_within regulation of membrane potential  
involved_in regulation of monoatomic cation transmembrane transport PubMed 
involved_in regulation of monoatomic cation transmembrane transport  
involved_in regulation of neuronal synaptic plasticity PubMed 
acts_upstream_of_or_within regulation of postsynaptic membrane potential  
involved_in regulation of presynaptic membrane potential  
involved_in regulation of response to alcohol PubMed 
involved_in regulation of synaptic plasticity  
involved_in regulation of synaptic plasticity  
involved_in response to amine PubMed 
involved_in response to ammonium ion PubMed 
involved_in response to amphetamine  
acts_upstream_of_or_within response to amphetamine  
involved_in response to calcium ion PubMed 
involved_in response to carbohydrate PubMed 
involved_in response to cocaine PubMed 
involved_in response to environmental enrichment PubMed 
involved_in response to ethanol  
involved_in response to ethanol PubMed 
involved_in response to ethanol PubMed 
acts_upstream_of_or_within response to ethanol  
involved_in response to ethanol  
involved_in response to fungicide PubMed 
involved_in response to hydrogen sulfide PubMed 
involved_in response to lead ion PubMed 
involved_in response to light stimulus PubMed 
involved_in response to lithium ion PubMed 
involved_in response to manganese ion PubMed 
involved_in response to methylmercury PubMed 
involved_in response to nicotine PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to other organism PubMed 
involved_in response to wounding  
acts_upstream_of_or_within response to wounding  
involved_in response to xenobiotic stimulus  
involved_in response to xenobiotic stimulus PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus  
involved_in rhythmic process PubMed 
involved_in sensory perception of pain  
acts_upstream_of_or_within sensory perception of pain  
involved_in serotonin metabolic process  
acts_upstream_of_or_within serotonin metabolic process  
involved_in sleep  
acts_upstream_of_or_within sleep  
involved_in sodium ion transmembrane transport  
involved_in sodium ion transmembrane transport  
involved_in spinal cord development PubMed 
involved_in startle response  
NOT acts_upstream_of_or_within startle response  
acts_upstream_of_or_within startle response  
involved_in synaptic transmission, glutamatergic  
involved_in visual learning  
acts_upstream_of_or_within visual learning  
Items 1 - 25 of 129
Items 1 - 20 of 51
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex PubMed 
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex  
located_in cell surface PubMed 
located_in cell surface  
located_in cell surface  
located_in cytoplasm PubMed 
located_in cytoplasmic vesicle membrane  
located_in dendrite membrane PubMed 
located_in dendritic spine PubMed 
located_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum membrane  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in glutamatergic synapse  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
located_in membrane  
located_in neuron projection PubMed 
located_in neuron projection  
located_in neuron projection  
is_active_in parallel fiber to Purkinje cell synapse PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in postsynapse  
located_in postsynaptic density PubMed 
is_active_in postsynaptic density  
located_in postsynaptic density  
is_active_in postsynaptic density membrane  
located_in postsynaptic density membrane  
is_active_in postsynaptic density membrane  
located_in postsynaptic density, intracellular component PubMed 
located_in postsynaptic membrane PubMed 
located_in postsynaptic membrane  
located_in postsynaptic membrane PubMed 
is_active_in presynaptic membrane PubMed 
located_in presynaptic membrane PubMed 
located_in presynaptic membrane  
located_in presynaptic membrane  
located_in synapse  
located_in synapse PubMed 
located_in synaptic membrane  
located_in synaptic vesicle  
located_in synaptic vesicle  
located_in terminal bouton PubMed 
Items 1 - 20 of 51

General protein information

Preferred Names
glutamate receptor ionotropic, NMDA 2A
Names
N-methyl D-aspartate receptor subtype 2A
N-methyl-D-aspartate receptor subunit 2A
glutamate [NMDA] receptor subunit epsilon-1
glutamate receptor, ionotropic, N-methyl D-aspartate 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012573.4NP_036705.3  glutamate receptor ionotropic, NMDA 2A precursor

    See identical proteins and their annotated locations for NP_036705.3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010, M91561
    UniProtKB/Swiss-Prot
    O08948, Q00959, Q63728
    UniProtKB/TrEMBL
    A6K4L3, G3V9C5
    Related
    ENSRNOP00000042235.4, ENSRNOT00000044626.5
    Conserved Domains (5) summary
    cd06378
    Location:32392
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    COG0834
    Location:458541
    HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
    cd13718
    Location:403802
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:556828
    Lig_chan; Ligand-gated ion channel
    pfam10565
    Location:8391464
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    6136458..6560003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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