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Grin2b glutamate ionotropic receptor NMDA type subunit 2B [ Rattus norvegicus (Norway rat) ]

Gene ID: 24410, updated on 7-Jan-2025

Summary

Official Symbol
Grin2bprovided by RGD
Official Full Name
glutamate ionotropic receptor NMDA type subunit 2Bprovided by RGD
Primary source
RGD:2738
See related
EnsemblRapid:ENSRNOG00000008766 AllianceGenome:RGD:2738
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GluN2B
Summary
Enables several functions, including beta-catenin binding activity; extracellular ligand-gated monoatomic ion channel activity; and signaling receptor binding activity. Involved in several processes, including cellular response to ketone; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and synaptic cleft. Part of NMDA selective glutamate receptor complex. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; parallel fiber to Purkinje cell synapse; and synaptic membrane. Used to study attention deficit hyperactivity disorder; fetal alcohol spectrum disorder; hyperhomocysteinemia; and transient cerebral ischemia. Biomarker of several diseases, including attention deficit hyperactivity disorder; cognitive disorder (multiple); egg allergy; placental insufficiency; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 321.7) See more
Orthologs
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Genomic context

See Grin2b in Genome Data Viewer
Location:
4q43
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (170297811..170775420, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (168580824..169044110, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (169541620..170000216, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486686 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene uncharacterized LOC120102418 Neighboring gene RNA, U2 small nuclear 63 Neighboring gene zinc finger protein 84-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 34
Function Evidence Code Pubs
enables D2 dopamine receptor binding PubMed 
enables NMDA glutamate receptor activity  
enables NMDA glutamate receptor activity PubMed 
enables NMDA glutamate receptor activity  
enables NMDA glutamate receptor activity  
enables beta-catenin binding PubMed 
enables calcium channel activity  
enables cell adhesion molecule binding PubMed 
enables extracellularly glutamate-gated ion channel activity PubMed 
enables glutamate binding PubMed 
enables glutamate receptor binding PubMed 
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated calcium ion channel activity  
enables glutamate-gated receptor activity PubMed 
enables glycine binding  
enables glycine binding  
enables heterocyclic compound binding PubMed 
enables interleukin-1 receptor binding PubMed 
enables ionotropic glutamate receptor binding PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential  
enables metal ion binding  
enables monoatomic cation channel activity  
enables protein binding PubMed 
enables protein tyrosine kinase binding PubMed 
enables protein-containing complex binding PubMed 
enables scaffold protein binding PubMed 
enables signaling receptor binding PubMed 
enables small molecule binding PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential PubMed 
enables zinc ion binding PubMed 
Items 1 - 25 of 34
Items 1 - 25 of 96
Process Evidence Code Pubs
involved_in action potential PubMed 
involved_in associative learning PubMed 
involved_in auditory behavior PubMed 
involved_in behavioral fear response PubMed 
acts_upstream_of_or_within behavioral fear response  
acts_upstream_of_or_within behavioral response to pain  
involved_in calcium ion transmembrane import into cytosol  
involved_in calcium ion transmembrane import into cytosol  
involved_in calcium ion transmembrane import into cytosol  
acts_upstream_of_or_within calcium ion transport  
involved_in calcium-mediated signaling  
involved_in cellular response to amino acid stimulus PubMed 
involved_in cellular response to corticosterone stimulus PubMed 
involved_in cellular response to curcumin PubMed 
involved_in cellular response to dsRNA PubMed 
involved_in cellular response to forskolin PubMed 
involved_in cellular response to growth factor stimulus PubMed 
involved_in cellular response to lipid PubMed 
involved_in cellular response to magnesium starvation PubMed 
involved_in cellular response to manganese ion PubMed 
involved_in cellular response to organic cyclic compound PubMed 
involved_in cerebral cortex development PubMed 
acts_upstream_of_or_within chemical synaptic transmission  
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain  
involved_in excitatory postsynaptic potential  
acts_upstream_of_or_within excitatory postsynaptic potential  
acts_upstream_of_or_within fear response  
involved_in hippocampus development PubMed 
acts_upstream_of_or_within in utero embryonic development  
involved_in intracellular calcium ion homeostasis PubMed 
involved_in ionotropic glutamate receptor signaling pathway PubMed 
involved_in ionotropic glutamate receptor signaling pathway  
involved_in ionotropic glutamate receptor signaling pathway  
acts_upstream_of_or_within learning  
involved_in learning or memory PubMed 
involved_in learning or memory PubMed 
involved_in long-term memory PubMed 
involved_in long-term synaptic potentiation  
involved_in long-term synaptic potentiation PubMed 
acts_upstream_of_or_within long-term synaptic potentiation  
involved_in memory PubMed 
acts_upstream_of_or_within memory  
involved_in monoatomic cation transmembrane transport  
involved_in monoatomic cation transmembrane transport  
acts_upstream_of_or_within monoatomic cation transport  
involved_in multicellular organismal response to stress PubMed 
involved_in negative regulation of dendritic spine maintenance  
involved_in neuron development PubMed 
involved_in positive regulation of excitatory postsynaptic potential PubMed 
involved_in positive regulation of excitatory postsynaptic potential PubMed 
involved_in positive regulation of excitatory postsynaptic potential  
involved_in positive regulation of glutamate secretion PubMed 
involved_in positive regulation of inhibitory postsynaptic potential PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic  
involved_in protein heterotetramerization PubMed 
involved_in receptor clustering PubMed 
involved_in regulation of ARF protein signal transduction PubMed 
involved_in regulation of MAPK cascade PubMed 
acts_upstream_of_or_within regulation of cAMP/PKA signal transduction  
involved_in regulation of long-term neuronal synaptic plasticity PubMed 
involved_in regulation of monoatomic cation transmembrane transport  
involved_in regulation of neuronal synaptic plasticity PubMed 
acts_upstream_of_or_within regulation of postsynaptic membrane potential  
involved_in regulation of presynaptic membrane potential  
acts_upstream_of_or_within regulation of synaptic plasticity  
involved_in response to amine PubMed 
involved_in response to amphetamine PubMed 
involved_in response to calcium ion PubMed 
involved_in response to carbohydrate PubMed 
involved_in response to cocaine PubMed 
involved_in response to cytokine PubMed 
involved_in response to electrical stimulus PubMed 
involved_in response to ethanol  
involved_in response to ethanol PubMed 
acts_upstream_of_or_within response to ethanol  
involved_in response to ethanol  
involved_in response to fungicide PubMed 
involved_in response to growth hormone PubMed 
involved_in response to hydrogen sulfide PubMed 
involved_in response to hypoxia PubMed 
involved_in response to lead ion PubMed 
involved_in response to magnesium ion PubMed 
involved_in response to manganese ion PubMed 
involved_in response to mechanical stimulus PubMed 
involved_in response to methylmercury PubMed 
involved_in response to nicotine PubMed 
involved_in response to organic cyclic compound PubMed 
involved_in response to other organism PubMed 
involved_in response to toxic substance PubMed 
involved_in rhythmic process PubMed 
involved_in sensitization PubMed 
acts_upstream_of_or_within sensory organ development  
acts_upstream_of_or_within startle response  
acts_upstream_of_or_within suckling behavior  
involved_in synaptic transmission, glutamatergic  
Items 1 - 25 of 96
Items 1 - 20 of 56
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex PubMed 
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex  
part_of NMDA selective glutamate receptor complex  
located_in Z disc PubMed 
located_in apical dendrite PubMed 
located_in cell surface PubMed 
located_in cell surface  
located_in cytoplasm PubMed 
located_in cytoskeleton  
located_in dendritic branch PubMed 
located_in dendritic spine PubMed 
located_in endoplasmic reticulum membrane  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
is_active_in hippocampal mossy fiber to CA3 synapse PubMed 
located_in late endosome  
located_in late endosome  
located_in lysosome  
located_in lysosome  
located_in membrane  
located_in membrane  
located_in neuron projection PubMed 
located_in neuron projection  
located_in neuronal cell body PubMed 
is_active_in parallel fiber to Purkinje cell synapse PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
located_in postsynapse  
located_in postsynaptic density PubMed 
is_active_in postsynaptic density  
located_in postsynaptic density  
is_active_in postsynaptic density membrane  
is_active_in postsynaptic density membrane PubMed 
is_active_in postsynaptic density membrane  
located_in postsynaptic density, intracellular component PubMed 
located_in postsynaptic membrane PubMed 
located_in postsynaptic membrane  
located_in postsynaptic membrane  
located_in postsynaptic membrane PubMed 
is_active_in presynaptic active zone membrane PubMed 
is_active_in presynaptic membrane PubMed 
located_in presynaptic membrane PubMed 
located_in presynaptic membrane  
located_in synapse PubMed 
located_in synapse  
located_in synapse PubMed 
located_in synaptic cleft PubMed 
located_in synaptic membrane  
located_in synaptic vesicle  
located_in terminal bouton PubMed 
Items 1 - 20 of 56

General protein information

Preferred Names
glutamate receptor ionotropic, NMDA 2B
Names
N-methyl D-aspartate receptor subtype 2B
NMDAR2B
NR2B
glutamate [NMDA] receptor subunit epsilon-2
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
glutamate receptor, ionotropic, NMDA2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012574.1NP_036706.1  glutamate receptor ionotropic, NMDA 2B precursor

    See identical proteins and their annotated locations for NP_036706.1

    Status: PROVISIONAL

    Source sequence(s)
    U11419
    UniProtKB/Swiss-Prot
    Q00960, Q62684
    Related
    ENSRNOP00000011697.3, ENSRNOT00000011697.6
    Conserved Domains (5) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    COG0834
    Location:459542
    HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:557829
    Lig_chan; Ligand-gated ion channel
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    170297811..170775420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592437.3XP_017447926.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    UniProtKB/Swiss-Prot
    Q00960, Q62684
    UniProtKB/TrEMBL
    A6IMH0, G3V746
    Conserved Domains (5) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    COG0834
    Location:459542
    HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:557829
    Lig_chan; Ligand-gated ion channel
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  2. XM_017592438.3XP_017447927.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    UniProtKB/Swiss-Prot
    Q00960, Q62684
    UniProtKB/TrEMBL
    A6IMH0, G3V746
    Conserved Domains (5) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    COG0834
    Location:459542
    HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:557829
    Lig_chan; Ligand-gated ion channel
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  3. XM_017592439.3XP_017447928.1  glutamate receptor ionotropic, NMDA 2B isoform X2

    UniProtKB/Swiss-Prot
    Q00960, Q62684
    Related
    ENSRNOP00000102212.1, ENSRNOT00000159969.1
  4. XM_017592436.3XP_017447925.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    UniProtKB/Swiss-Prot
    Q00960, Q62684
    UniProtKB/TrEMBL
    A6IMH0, G3V746
    Conserved Domains (5) summary
    cd06378
    Location:33393
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    COG0834
    Location:459542
    HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
    cd13718
    Location:403803
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:557829
    Lig_chan; Ligand-gated ion channel
    pfam10565
    Location:8401482
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
  5. XM_063285520.1XP_063141590.1  glutamate receptor ionotropic, NMDA 2B isoform X1

    UniProtKB/Swiss-Prot
    Q00960, Q62684
    UniProtKB/TrEMBL
    A6IMH0, G3V746
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