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Ubqln3 ubiquilin 3 [ Mus musculus (house mouse) ]

Gene ID: 244178, updated on 9-May-2024

Summary

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Official Symbol
Ubqln3provided by MGI
Official Full Name
ubiquilin 3provided by MGI
Primary source
MGI:MGI:3045291
See related
Ensembl:ENSMUSG00000051618 AllianceGenome:MGI:3045291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933400K24Rik
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Is expressed in olfactory epithelium. Orthologous to human UBQLN3 (ubiquilin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 198.8) See more
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Genomic context

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See Ubqln3 in Genome Data Viewer
Location:
7 E3; 7 54.85 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103789828..103792528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104140625..104143295, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily D member 1 Neighboring gene STARR-seq mESC enhancer starr_19730 Neighboring gene ubiquilin 5 Neighboring gene ubiquilin-like Neighboring gene olfactomedin 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice. Yuan S, et al. Mol Reprod Dev, 2015 Apr. PMID 25776854, Free PMC Article
  2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice.
    Title: Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquilin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384184.1 → NP_001371113.1  ubiquilin-3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC123830
    UniProtKB/TrEMBL
    B2RWV8
    Conserved Domains (3) summary
    smart00727
    Location:212 → 256
    STI1; Heat shock chaperonin-binding motif
    cd14399
    Location:641 → 678
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    cd01808
    Location:43 → 115
    Ubl_PLICs; ubiquitin-like (Ubl) domain found in eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

  2. NM_198623.3 → NP_941025.1  ubiquilin-3 isoform 2

    See identical proteins and their annotated locations for NP_941025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC123830
    Consensus CDS
    CCDS21610.1
    UniProtKB/Swiss-Prot
    Q8C5U9
    UniProtKB/TrEMBL
    B2RWV8, Q497R3
    Conserved Domains (3) summary
    smart00727
    Location:189 → 233
    STI1; Heat shock chaperonin-binding motif
    cd14399
    Location:618 → 655
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    cd01808
    Location:20 → 92
    Ubl_PLICs; ubiquitin-like (Ubl) domain found in eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    103789828..103792528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153120.1 → XP_036009013.1  ubiquilin-3 isoform X1

    UniProtKB/Swiss-Prot
    Q8C5U9
    UniProtKB/TrEMBL
    B2RWV8, Q497R3
    Related
    ENSMUSP00000055229.6, ENSMUST00000057254.6
    Conserved Domains (3) summary
    smart00727
    Location:189 → 233
    STI1; Heat shock chaperonin-binding motif
    cd14399
    Location:618 → 655
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    cd01808
    Location:20 → 92
    Ubl_PLICs; ubiquitin-like (Ubl) domain found in eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C5U9.1 GenPept UniProtKB/Swiss-Prot:Q8C5U9

Gene LinkOut

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