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Ppp1r3b protein phosphatase 1, regulatory subunit 3B [ Mus musculus (house mouse) ]

Gene ID: 244416, updated on 25-Apr-2024

Summary

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Official Symbol
Ppp1r3bprovided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 3Bprovided by MGI
Primary source
MGI:MGI:2177268
See related
Ensembl:ENSMUSG00000046794 AllianceGenome:MGI:2177268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GL; PTG; 6430576E21
Summary
Predicted to enable several functions, including [phosphorylase] phosphatase activity; glycogen binding activity; and protein phosphatase 1 binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within regulation of glycogen catabolic process. Predicted to be located in glycogen granule and intracellular membrane-bounded organelle. Predicted to be part of protein phosphatase type 1 complex. Is expressed in several structures, including alimentary system; hindlimb mesenchyme; respiratory system; sensory organ; and urinary system. Orthologous to human PPP1R3B (protein phosphatase 1 regulatory subunit 3B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 47.3), liver E18 (RPKM 22.7) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp1r3b in Genome Data Viewer
Location:
8 A4; 8 21.16 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (35842847..35855293)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (35375694..35388139)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:36313763-36314027 Neighboring gene predicted gene, 34647 Neighboring gene STARR-seq mESC enhancer starr_21182 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:36384665-36384970 Neighboring gene predicted gene, 34705 Neighboring gene predicted gene 45301 Neighboring gene predicted gene, 34911 Neighboring gene predicted gene, 51567

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis. Mehta MB, et al. J Biol Chem, 2017 Jun 23. PMID 28473467, Free PMC Article
  2. Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride. Stender S, et al. Hepatology, 2018 Jun. PMID 29266543, Free PMC Article
  3. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. von Wilamowitz-Moellendorff A, et al. Diabetes, 2013 Dec. PMID 23990365, Free PMC Article
  4. Identification and expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells. Niimi T, et al. Biochem Biophys Res Commun, 2006 Oct 20. PMID 16949035
  5. Human skeletal muscle expresses a glycogen-targeting subunit of PP1 that is identical to the insulin-sensitive glycogen-targeting subunit G(L) of liver. Munro S, et al. Diabetes, 2002 Mar. PMID 11872655

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b.
    Title: mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b.
  2. Mice lacking protein phosphatase 1 regulatory subunit 3B (PPP1R3B) were deficient in hepatic glycogen, whereas HTGC was unchanged. Hepatic overexpression of PPP1R3B caused accumulation of hepatic glycogen and elevated plasma levels of ALT, but did not change HTGC
    Title: Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride.
  3. findings indicate a major role for Ppp1r3b in regulating hepatic glycogen stores and whole-body glucose/energy homeostasis.
    Title: Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis.
  4. analysis of expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells
    Title: Identification and expression of alternative splice variants of the mouse Ppp1r3b gene in lung epithelial cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables [phosphorylase] phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables glycogen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glycogen biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in glycogen granule ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 3B
Names
PP1 subunit R4
hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL
protein phosphatase 1 regulatory subunit 4
protein phosphatase 1, regulatory (inhibitor) subunit 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364450.1 → NP_001351379.1  protein phosphatase 1 regulatory subunit 3B

    Status: VALIDATED

    Source sequence(s)
    BC079666, CD355429
    Consensus CDS
    CCDS22243.1
    UniProtKB/Swiss-Prot
    Q6PAJ7, Q8C767
    Related
    ENSMUSP00000147736.2, ENSMUST00000210337.2
    Conserved Domains (1) summary
    pfam03370
    Location:126 → 231
    CBM_21; Carbohydrate/starch-binding module (family 21)

  2. NM_001364451.1 → NP_001351380.1  protein phosphatase 1 regulatory subunit 3B

    Status: VALIDATED

    Source sequence(s)
    AC159316
    Consensus CDS
    CCDS22243.1
    UniProtKB/Swiss-Prot
    Q6PAJ7, Q8C767
    Related
    ENSMUSP00000147633.2, ENSMUST00000211648.2
    Conserved Domains (1) summary
    pfam03370
    Location:126 → 231
    CBM_21; Carbohydrate/starch-binding module (family 21)

  3. NM_001364452.1 → NP_001351381.1  protein phosphatase 1 regulatory subunit 3B

    Status: VALIDATED

    Source sequence(s)
    BC060261, BC079666, BY784264
    Consensus CDS
    CCDS22243.1
    UniProtKB/Swiss-Prot
    Q6PAJ7, Q8C767
    Conserved Domains (1) summary
    pfam03370
    Location:126 → 231
    CBM_21; Carbohydrate/starch-binding module (family 21)

  4. NM_177741.4 → NP_808409.1  protein phosphatase 1 regulatory subunit 3B

    See identical proteins and their annotated locations for NP_808409.1

    Status: VALIDATED

    Source sequence(s)
    BC079666
    Consensus CDS
    CCDS22243.1
    UniProtKB/Swiss-Prot
    Q6PAJ7, Q8C767
    Related
    ENSMUSP00000065679.7, ENSMUST00000070481.8
    Conserved Domains (1) summary
    pfam03370
    Location:126 → 231
    CBM_21; Carbohydrate/starch-binding module (family 21)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    35842847..35855293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312797.3 → XP_017168286.1  protein phosphatase 1 regulatory subunit 3B isoform X1

    UniProtKB/Swiss-Prot
    Q6PAJ7, Q8C767
    Conserved Domains (1) summary
    pfam03370
    Location:126 → 231
    CBM_21; Carbohydrate/starch-binding module (family 21)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C767.1 GenPept UniProtKB/Swiss-Prot:Q8C767

Gene LinkOut

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