Ibsp integrin-binding sialoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ibspprovided by RGD
Official Full Name: integrin-binding sialoproteinprovided by RGD
Primary source: RGD:2855
See related: Ensembl:ENSRNOG00000002158 AllianceGenome:RGD:2855
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bsp
Summary: Predicted to enable integrin binding activity. Involved in cell adhesion. Located in extracellular space and vesicle. Orthologous to human IBSP (integrin binding sialoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 35.0), Lung (RPKM 5.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (5744497..5757242, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (5439825..5452570, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (6801200..6813987, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IGF-II increased BSP transcription by targeting CRE, FRE and HOX elements in the proximal promoter of the rat BSP gene. Moreover, phospho-CREB1, c-Fos, c-Jun, Dlx5 and Runx2 transcription factors appear to be key regulators of IGF-II effects on BSP transcription.
Title: Insulin-like growth factor-II regulates bone sialoprotein gene transcription.
ERalpha stimulates BSP gene transcription in a ligand-independent manner by targeting the cAMP response element and AP1/glucocorticoid response elements in the rat BSP gene promoter.
Title: Unliganded estrogen receptor α stimulates bone sialoprotein gene expression.
Protamine stimulates bone sialoprotein gene expression.
Title: Protamine stimulates bone sialoprotein gene expression.
These findings indicate that ET-1 increases BSP transcription via the CRE, FRE and HOX sites in the rat BSP gene promoter.
Title: Endothelin-1 regulates rat bone sialoprotein gene transcription.
These studies demonstrate that SPG25, a polyphosphate stimulates BSP transcription by targeting FRE and HOX elements in the proximal promoter of the rat BSP gene.
Title: Effects of inorganic polyphosphate on bone sialoprotein gene expression.
Upon binding to collagen, rBSP displays an increase in nucleation potency, implying a co-operative effect of BSP and collagen in mineral formation
Title: Bone sialoprotein-collagen interaction promotes hydroxyapatite nucleation.
The orientation of BSP for MC3T3-E1 cell adhesion when it was specifically bound to collagen is examined and compared with OPN.
Title: Adhesion of MC3T3-E1 cells to bone sialoprotein and bone osteopontin specifically bound to collagen I.
gene transcription is stimulated by FGF2 by targeting the FRE and AP1/GRE elements in the rat bone sialoprotein gene promoter
Title: AP1 binding site is another target of FGF2 regulation of bone sialoprotein gene transcription.
Androgen receptor stimulates BSP gene transcription by targeting the cAMP response element (RE) and AP1/glucocorticoid RE elements in the promoter of the rat BSP gene.
Title: Androgen receptor stimulates bone sialoprotein (BSP) gene transcription via cAMP response element and activator protein 1/glucocorticoid response elements.
BSP may serve as a matrix-associated signal directly promoting osteoblast differentiation resulting in the increased production of a mineralized matrix.
Title: Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

D14Arb1 (e-PCR), detects polymorphism
- UniSTS:226592

RH94679 (e-PCR)
- UniSTS:119926

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	IEA Inferred from Electronic Annotation more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in ossification	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: integrin-binding sialoprotein; bone sialoprotein 2

Names: BSP II; bone sialoprotein II; cell-binding sialoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012587.2 → NP_036719.2 integrin-binding sialoprotein precursor

See identical proteins and their annotated locations for NP_036719.2

Status: VALIDATED

Source sequence(s)

BC127506, CB324054, DY313346, DY314698

UniProtKB/TrEMBL

A0JPM6, Q3HLN4

Related

ENSRNOP00000002938.2, ENSRNOT00000002938.4

Conserved Domains (1) summary

pfam05432
Location:17 → 316

BSP_II; Bone sialoprotein II (BSP-II)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

5744497..5757242 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599076.3 → XP_017454565.1 bone sialoprotein 2 isoform X1

UniProtKB/TrEMBL

A0JPM6, Q3HLN4

Conserved Domains (1) summary

pfam05432
Location:17 → 316

BSP_II; Bone sialoprotein II (BSP-II)