Zc3h12c zinc finger CCCH type containing 12C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zc3h12cprovided by MGI
Official Full Name: zinc finger CCCH type containing 12Cprovided by MGI
Primary source: MGI:MGI:3026959
See related: Ensembl:ENSMUSG00000035164 AllianceGenome:MGI:3026959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1726; A230108E06; C230027N18Rik
Summary: Predicted to enable endoribonuclease activity and mRNA binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12C (zinc finger CCCH-type containing 12C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 3.2), whole brain E14.5 (RPKM 3.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 28.62 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (52020869..52080028, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (52109569..52168730, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology.
Title: Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology.
The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
Title: The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.
PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
Title: PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases.
Gfi1 and Zc3h12c orchestrate a negative feedback loop that inhibits NF-kB activation during inflammation in macrophages.
Title: Gfi1 and Zc3h12c orchestrate a negative feedback loop that inhibits NF-kB activation during inflammation in macrophages.
required for immune homeostasis and regulation of the interferon pathway
Title: Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation.
Title: A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit4 (e-PCR), detects polymorphism
- UniSTS:131931

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable ribonuclease ZC3H12C

Names: regnase-3; zinc finger CCCH domain-containing protein 12C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162921.2 → NP_001156393.1 probable ribonuclease ZC3H12C isoform 1

Status: VALIDATED

Source sequence(s)

CT009732

Consensus CDS

CCDS52794.1

UniProtKB/TrEMBL

E9Q1I3

Related

ENSMUSP00000127603.2, ENSMUST00000165519.2

Conserved Domains (2) summary

PHA03160
Location:519 → 762

PHA03160; hypothetical protein; Provisional

pfam11977
Location:264 → 420

RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
NM_001368810.1 → NP_001355739.1 probable ribonuclease ZC3H12C isoform 2

Status: VALIDATED

Source sequence(s)

CT009732

Conserved Domains (2) summary

cl25932
Location:500 → 743

Peptidase_S21; Assemblin (Peptidase family S21)

cd18729
Location:249 → 379

PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

52020869..52080028 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510333.4 → XP_006510396.1 probable ribonuclease ZC3H12C isoform X1

See identical proteins and their annotated locations for XP_006510396.1

UniProtKB/Swiss-Prot

Q5DTV4

Related

ENSMUSP00000150821.2, ENSMUST00000213645.2

Conserved Domains (5) summary

cl25932
Location:500 → 743

Peptidase_S21; Assemblin (Peptidase family S21)

cd18729
Location:249 → 379

PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins

pfam18039
Location:163 → 204

UBA_6; UBA-like domain

pfam18044
Location:416 → 434

zf-CCCH_4; CCCH-type zinc finger

pfam18561
Location:836 → 879

Regnase_1_C; Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain