Il6r interleukin 6 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il6rprovided by RGD
Official Full Name: interleukin 6 receptorprovided by RGD
Primary source: RGD:2902
See related: Ensembl:ENSRNOG00000020811 AllianceGenome:RGD:2902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IL6R1; Il6ra
Summary: Predicted to enable several functions, including cytokine binding activity; cytokine receptor activity; and protein homodimerization activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and interleukin-6 receptor binding activity. Involved in several processes, including response to cAMP; response to gamma radiation; and response to lipopolysaccharide. Located in extracellular space and neuronal cell body membrane. Biomarker of several diseases, including congestive heart failure; mental depression; orchitis; sciatic neuropathy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 128.0), Spleen (RPKM 103.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (177582020..177646705, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (175289157..175347719, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (189196180..189255987, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-6 Receptor Blockade by Tocilizumab Has Anti-absence and Anti-epileptogenic Effects in the WAG/Rij Rat Model of Absence Epilepsy.
Title: IL-6 Receptor Blockade by Tocilizumab Has Anti-absence and Anti-epileptogenic Effects in the WAG/Rij Rat Model of Absence Epilepsy.
The role of interleukin-6/interleukin-6 receptor signaling in the mechanical stress-induced extracellular matrix remodeling of bladder smooth muscle.
Title: The role of interleukin-6/interleukin-6 receptor signaling in the mechanical stress-induced extracellular matrix remodeling of bladder smooth muscle.
CRNDE could induce interleukin 6 receptor (IL6R) expression positively.
Title: CRNDE enhances neuropathic pain via modulating miR-136/IL6R axis in CCI rat models.
Aerobic exercise improves the lipid metabolism disorder and interferes with germ cell apoptosis by reducing interleukin-6 and interleukin-6 receptor expression in nutritional obesity rat model.
Title: Aerobic exercise blocks interleukin-6 levels and germ cell apoptosis in obese rats.
Diabetic rats show an increase in the contractions of distal colon partly via the IL-6-IL-6 receptor pathway.
Title: Interleukin-6 (IL-6) mediated the increased contraction of distal colon in streptozotocin-induced diabetes in rats via IL-6 receptor pathway.
antisense to IL-6 receptor subunit gp130 (gp130), but not to tumor necrosis factor receptor type 1 (TNFR1), inhibited hyperalgesia in NLB rats. However, antisense against either gp130 or TNFR1 inhibited sound stress-induced enhancement of hyperalgesia.
Title: Stress in the adult rat exacerbates muscle pain induced by early-life stress.
Paradoxically, the association of pregnancy, inflammation and anti-IL-6R increases the inflammatory effects of LPS.
Title: Effect of interleukin-6 receptor blockade on feto-maternal outcomes in a rat model of intrauterine inflammation.
CB1R and IL-6R co-stimulation enhanced the differentiation of rat cortical neuron primary cultures.
Title: Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth.
Asymmetrical release of brain IL-6 by cerebral cortical astrocytes to the inflammatory insults both in protein and mRNA levels.
Title: Asymmetrical release of interleukin-6 by cultured cerebral cortical astrocytes treated with lipopolysaccharide.
Results suggest that the ERK1/2 pathway is involved in the process of lipopolysaccharide-induced IL-6R alpha up-regulation in leptomeningeal cells.
Title: Lipopolysaccharide up-regulates IL-6R alpha expression in cultured leptomeningeal cells via activation of ERK1/2 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

RH132797 (e-PCR)
- UniSTS:216080

BM389764 (e-PCR)
- UniSTS:260525

RH127619 (e-PCR)
- UniSTS:210929

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor binding	IEA Inferred from Electronic Annotation more info
enables ciliary neurotrophic factor binding	ISO Inferred from Sequence Orthology more info
enables ciliary neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to ciliary neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables interleukin-11 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-11 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-6 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-6 binding	IEA Inferred from Electronic Annotation more info
enables interleukin-6 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-6 receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-6 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-6 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-6 receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables interleukin-6 receptor binding	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-6 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T-helper 17 cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocrine pancreas development	IEA Inferred from Electronic Annotation more info
involved_in endocrine pancreas development	ISO Inferred from Sequence Orthology more info
involved_in interleukin-11-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-6-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-6-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activation of Janus kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glomerular mesangial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gamma radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ciliary neurotrophic factor receptor complex	IEA Inferred from Electronic Annotation more info
part_of ciliary neurotrophic factor receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of interleukin-6 receptor complex	IEA Inferred from Electronic Annotation more info
part_of interleukin-6 receptor complex	ISO Inferred from Sequence Orthology more info
part_of interleukin-6 receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-6 receptor subunit alpha

Names: IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; interleukin 6 receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017020.3 → NP_058716.2 interleukin-6 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_058716.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P22273

UniProtKB/TrEMBL

A6J6I0, G3V8T6

Related

ENSRNOP00000028234.6, ENSRNOT00000028234.8

Conserved Domains (4) summary

smart00408
Location:39 → 93

IGc2; Immunoglobulin C-2 Type

smart00060
Location:213 → 290

FN3; Fibronectin type 3 domain

smart00410
Location:33 → 92

IG_like; Immunoglobulin like

cl21522
Location:114 → 210

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

177582020..177646705 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232588.5 → XP_006232650.1 interleukin-6 receptor subunit alpha isoform X3

UniProtKB/Swiss-Prot

P22273

Conserved Domains (4) summary

smart00408
Location:39 → 93

IGc2; Immunoglobulin C-2 Type

smart00060
Location:213 → 290

FN3; Fibronectin type 3 domain

smart00410
Location:33 → 92

IG_like; Immunoglobulin like

cl21522
Location:114 → 210

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006232587.5 → XP_006232649.1 interleukin-6 receptor subunit alpha isoform X2

UniProtKB/Swiss-Prot

P22273

Conserved Domains (4) summary

smart00408
Location:39 → 93

IGc2; Immunoglobulin C-2 Type

smart00060
Location:213 → 290

FN3; Fibronectin type 3 domain

smart00410
Location:33 → 92

IG_like; Immunoglobulin like

cl21522
Location:114 → 210

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_008761127.4 → XP_008759349.1 interleukin-6 receptor subunit alpha isoform X1

UniProtKB/Swiss-Prot

P22273

Conserved Domains (4) summary

smart00408
Location:39 → 93

IGc2; Immunoglobulin C-2 Type

smart00060
Location:213 → 290

FN3; Fibronectin type 3 domain

smart00410
Location:33 → 92

IG_like; Immunoglobulin like

cl21522
Location:114 → 210

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...