Mog myelin oligodendrocyte glycoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mogprovided by RGD
Official Full Name: myelin oligodendrocyte glycoproteinprovided by RGD
Primary source: RGD:3102
See related: Ensembl:ENSRNOG00000000775 AllianceGenome:RGD:3102
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable signaling receptor binding activity. Involved in aging; response to folic acid; and response to lipid. Located in cell surface; membrane raft; and myelin sheath. Used to study optic neuritis. Human ortholog(s) of this gene implicated in multiple sclerosis; narcolepsy; and optic neuritis. Orthologous to human MOG (myelin oligodendrocyte glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 239.2), Lung (RPKM 35.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (1514110..1528716)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (1513137..1523473)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (2003871..2014284)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The aim of this work was to explore the conformational characteristics of rat/mouse MOG35-55 immunodominant epitope. The results are discussed in terms of rational design of altered peptide ligands or non-peptide mimetics based on rat MOG35-55 that could be served as potential inhibitors of experimental autoimmune encephalomyelitis.
Title: A combined NMR and molecular dynamics simulation study to determine the conformational properties of rat/mouse 35-55 myelin oligodendrocyte glycoprotein epitope implicated in the induction of experimental autoimmune encephalomyelitis.
Identify nerve growth factor as a binding partner for MOG and demonstrate that this interaction is capable of sequestering NGF from TrkA-expressing neurons to modulate axon growth and survival.
Title: The myelin oligodendrocyte glycoprotein directly binds nerve growth factor to modulate central axon circuitry.
MOG(1-125) immunization resulted in an increased incidence of severe experimental autoimmune encephalomyelitis and was accompanied by an increased percentage of CXCR3-expressing CD4+ T cells producing IFNgamma in the CNS.
Title: MOG extracellular domain (p1-125) triggers elevated frequency of CXCR3+ CD4+ Th1 cells in the CNS of mice and induces greater incidence of severe EAE.
Mog levels are significantly increased in cerebellum following maternal deprivation.
Title: Early postnatal repeated maternal deprivation causes a transient increase in OMpg and BDNF in rat cerebellum suggesting precocious myelination.
OMgp was only expressed in the inner plexiform layer of rats with experimental ocular hypertension.
Title: The expression patterns of Nogo-A, myelin associated glycoprotein and oligodendrocyte myelin glycoprotein in the retina after ocular hypertension: the expression of myelin proteins in the retina in glaucoma.
Mechanistic studies reveal that myelin oligodendrocyte glycoprotein (Mog) suppresses long-term potentiation in a Nogo receptor-1 (NgR1)-dependent manner.
Title: Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity.
Thus, our study has provided evidence for temporospatial expression and cellular localization of OMgp following SCI and suggested that this molecule may contribute to the overall inhibition of axonal regeneration.
Title: Temporospatial expression and cellular localization of oligodendrocyte myelin glycoprotein (OMgp) after traumatic spinal cord injury in adult rats.
Diffusion of Mog in living OLN-93 cells was investigated by raster-scanning image correlation spectroscopy.
Title: Diffusion of myelin oligodendrocyte glycoprotein in living OLN-93 cells investigated by raster-scanning image correlation spectroscopy (RICS).
causes experimental autoimmune encephalitis when injected into Dark Agouti rats.
Title: Novel role for SLPI in MOG-induced EAE revealed by spinal cord expression analysis.
We found that after SCI, both OMgp and NgR expressions were detected in neurons and oligodendrocytes with a similar change profile that increased immediately and decreased gradually.
Title: Expression of oligodendrocyte myelin glycoprotein and its receptor NgR after the injury of rat central nervous system.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to folic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myelin-oligodendrocyte glycoprotein

Names: dystonia 2, torsion (autosomal recessive)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022668.2 → NP_073159.2 myelin-oligodendrocyte glycoprotein precursor

See identical proteins and their annotated locations for NP_073159.2

Status: VALIDATED

Source sequence(s)

BC087717

UniProtKB/Swiss-Prot

Q63345

UniProtKB/TrEMBL

F6PTF1, Q6MFX9

Related

ENSRNOP00000001008.1, ENSRNOT00000001008.4

Conserved Domains (2) summary

cd05713
Location:44 → 142

Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

smart00410
Location:38 → 142

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

1514110..1528716

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098414.2 → XP_038954342.1 myelin-oligodendrocyte glycoprotein isoform X2

Conserved Domains (2) summary

cd00096
Location:1 → 6

Ig; Ig strand C [structural motif]

cl11960
Location:1 → 81

Ig; Immunoglobulin domain
XM_006255867.5 → XP_006255929.1 myelin-oligodendrocyte glycoprotein isoform X1

UniProtKB/Swiss-Prot

Q63345

Conserved Domains (2) summary

cd05713
Location:44 → 142

Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

smart00410
Location:38 → 142

IG_like; Immunoglobulin like