Cd200 Cd200 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd200provided by RGD
Official Full Name: Cd200 moleculeprovided by RGD
Primary source: RGD:3104
See related: Ensembl:ENSRNOG00000002141 AllianceGenome:RGD:3104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mox2; Cspmo2; MRCOX2
Summary: Enables protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including negative regulation of interleukin-6 production; negative regulation of leukocyte migration; and negative regulation of neuroinflammatory response. Located in cell surface; neuron projection; and neuronal cell body. Orthologous to human CD200 (CD200 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 878.4), Brain (RPKM 271.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (68916200..68943570)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (55410166..55437527)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (60371617..60398450)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats.
Title: Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats.
PPAR-gamma promotes the polarization of rat retinal microglia to M2 phenotype by regulating the expression of CD200-CD200R1 under hypoxia.
Title: PPAR-γ promotes the polarization of rat retinal microglia to M2 phenotype by regulating the expression of CD200-CD200R1 under hypoxia.
Specificity of CD200/CD200R pathway in LPS-induced lung inflammation.
Title: Specificity of CD200/CD200R pathway in LPS-induced lung inflammation.
The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke.
Title: The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke.
Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems.
Title: Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems.
Using a retinoic acid-induced rat model of spina bifida study demonstrate microglial down-regulation of CD200 expression and up-regulation of CD200R. Findings provide new evidence that microglia activation, including the disruption of the endogenous inhibitory system (CD200-CD200R), may participate in the pathogenesis of spina bifida through late gestation.
Title: CD200-CD200R imbalance correlates with microglia and pro-inflammatory activation in rat spinal cords exposed to amniotic fluid in retinoic acid-induced spina bifida.
CD200R expression is up-regulated in a cell model of peripheral blood monocyte tolerance following induced neuroinflammation.
Title: Peripheral Blood Monocyte Tolerance Alleviates Intraperitoneal Lipopolysaccharides-Induced Neuroinflammation in Rats Via Upregulating the CD200R Expression.
evidence indicates that this is a consequence of increased phagocytosis, associated with increased lysosomal activity in CD200-deficient microglia
Title: Analysis of the Impact of CD200 on Phagocytosis.
Subcutaneous transplantation of C6 glioma cells in rat back metastasized into the lung. Two CD200 variants are full-length CD200 (CD200L) and truncated CD200 (CD200S). CD200S-expressing C6 cells reduced lung metastasis and elongated survival period of rats.
Title: Truncated CD200 stimulates tumor immunity leading to fewer lung metastases in a novel Wistar rat metastasis model.
These results suggest that CD200S activates TAMs to become DC-like antigen presenting cells, leading to the activation of CD8(+) cytotoxic T lymphocytes, which induce apoptotic elimination of tumor cells.
Title: A Truncated form of CD200 (CD200S) Expressed on Glioma Cells Prolonged Survival in a Rat Glioma Model by Induction of a Dendritic Cell-Like Phenotype in Tumor-Associated Macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Wox3 (e-PCR)
- UniSTS:118035

RH133122 (e-PCR)
- UniSTS:216405

D11Arb6 (e-PCR)
- UniSTS:239702

AF004023 (e-PCR)
- UniSTS:180921

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cell-cell adhesion mediator activity	IEA Inferred from Electronic Annotation more info
enables protein binding involved in heterotypic cell-cell adhesion	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterotypic cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterotypic cell-cell adhesion	IPI Inferred from Physical Interaction more info	PubMed
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of matrix metallopeptidase secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of matrix metallopeptidase secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuroinflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuroinflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transforming growth factor beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuroinflammatory response	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: OX-2 membrane glycoprotein

Names: Cd200 antigen; MRC OX-2 antigen; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031518.3 → NP_113706.2 OX-2 membrane glycoprotein precursor

See identical proteins and their annotated locations for NP_113706.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

P04218

UniProtKB/TrEMBL

A0A5D0, A6IQY8

Related

ENSRNOP00000055253.2, ENSRNOT00000058453.4

Conserved Domains (2) summary

cd05846
Location:44 → 140

Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins

pfam00047
Location:143 → 229

ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

68916200..68943570

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597873.2 → XP_017453362.1 OX-2 membrane glycoprotein isoform X2
XM_006248325.5 → XP_006248387.2 OX-2 membrane glycoprotein isoform X1

UniProtKB/TrEMBL

A0A1W2Q5Z8

Conserved Domains (3) summary

pfam00047
Location:175 → 261

ig; Immunoglobulin domain

cd00096
Location:199 → 205

Ig; Ig strand C [structural motif]

cd05846
Location:64 → 171

IgV_1_MRC-OX-2_like; First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains
XM_017597875.2 → XP_017453364.1 OX-2 membrane glycoprotein isoform X3