Kir3dl1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kir3dl1provided by MGI
Official Full Name: killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1provided by MGI
Primary source: MGI:MGI:2652397
See related: Ensembl:ENSMUSG00000031424 AllianceGenome:MGI:2652397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Krl1; Kirl1; Kirl2
Summary: Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human KIR3DL3 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: X F1; X 58.77 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (135418748..135435055)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (136517999..136534306)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

studies indicate that KIR3DL1 expression may negatively regulate Treg function and suggest a previously undescribed target for improving immune tolerance for potential treatment of autoimmune diseases like IDDM
Title: Killer cell Ig-like receptor (KIR) 3DL1 down-regulation enhances inhibition of type 1 diabetes by autoantigen-specific regulatory T cells.
cloned Kir cDNAs from multiple strains of mice. Sequencing of the cDNA clones showed that the Kir3dl1 gene is found in C3H/HeJ and CBA/J but not in B6 mice.
Title: Expression of murine killer immunoglobulin-like receptor KIRL1 on CD1d-independent NK1.1(+) T cells.
Selective expression of killer cell immunoglobulin-like receptor (KIR) genes in subregions of the mouse brain where synaptic plasticity and neurogenesis occur, including olfactory bulbs, rostral migratory stream and dentate gyrus of hippocampus.
Title: Expression of a killer cell receptor-like gene in plastic regions of the central nervous system.
first close rodent homologue of the NK receptor KIR family; shares 40% amino acid identity with primate KIR family members
Title: Identification of the mouse killer immunoglobulin-like receptor-like (Kirl) gene family mapping to chromosome X.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:485048

Kir3dl1 (e-PCR), detects polymorphism
- UniSTS:256443

NoName (e-PCR)
- UniSTS:494282

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class Ib protein binding	ISO Inferred from Sequence Orthology more info
enables MHC class Ib receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: killer cell immunoglobulin-like receptor 3DL1

Names: KIR-like receptor 1; killer cell immunoglobulin-like receptor Kir3dl1; killer immunoglobulin receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310690.1 → NP_001297619.1 killer cell immunoglobulin-like receptor 3DL1 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AL672068, AY152727, AY530782

Consensus CDS

CCDS81176.1

UniProtKB/TrEMBL

D3Z751

Related

ENSMUSP00000108728.2, ENSMUST00000113104.8

Conserved Domains (1) summary

cl11960
Location:28 → 124

Ig; Immunoglobulin domain
NM_177749.4 → NP_808417.2 killer cell immunoglobulin-like receptor 3DL1 isoform 1 precursor

See identical proteins and their annotated locations for NP_808417.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AY152727, AY530782

Consensus CDS

CCDS41134.1

UniProtKB/Swiss-Prot

P83555

UniProtKB/TrEMBL

Q673W3, Q673W4

Related

ENSMUSP00000108729.3, ENSMUST00000113105.3

Conserved Domains (2) summary

smart00410
Location:35 → 95

IG_like; Immunoglobulin like

cl11960
Location:121 → 217

Ig; Immunoglobulin domain