Klk1b3 kallikrein 1-related peptidase B3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klk1b3provided by RGD
Official Full Name: kallikrein 1-related peptidase B3provided by RGD
Primary source: RGD:3175
See related: Ensembl:ENSRNOG00000068069 AllianceGenome:RGD:3175
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Klk1; Ngfg; rK-1; Klna4; rGK-1; Klk1c1
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of systemic arterial blood pressure and zymogen activation. Predicted to be active in secretory granule. Used to study hypertension. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to human KLK1 (kallikrein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1905.4) See more
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Genomic context

Location:: 1q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (103845647..103849854)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (94709105..94713308)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100199057..100203260)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ability of hTK gene-transduced EPCs can be enhanced in vitro, in which integrin alphavbeta3 plays a role in the process
Title: Kallikrein gene-modified EPCs induce angiogenesis in rats with ischemic hindlimb and correlate with integrin αvβ3 expression.
Observations demonstrate a novel role of plasma kallikrein and bradykinin activation in the synovial recruitment of endothelial stem cells in arthritis, acting via kallikrein activation and B2R-dependent mechanisms.
Title: Role of plasma kallikrein-kinin system activation in synovial recruitment of endothelial progenitor cells in experimental arthritis.
Results suggest that the results suggest that the kallikrein-kinin system (KKS) plays a role in the effects of radiation on cardiac function and recruitment of inflammatory cells.
Title: Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system.
The study demonstrates a novel role of TK in skin wound healing uncovering new signaling pathway mediated by TK in promoting keratinocyte migration through activation of the PAR(1)-PKC-Src-MMP pathway and HB-EGF/AR shedding-dependent EGFR transactivation.
Title: A novel signaling pathway of tissue kallikrein in promoting keratinocyte migration: activation of proteinase-activated receptor 1 and epidermal growth factor receptor.
The present findings suggest that at least NGF does not act as a proper proinflammatory factor but most probably as a neuroimmune modulator molecule of the allergic state.
Title: Allergic bronchial airway inflammation in nerve growth factor (NGF)-deprived rats: evidence suggesting a neuroimmunomodulatory role of NGF.
PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling
Title: PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells.
the the kallikrein-kinin system has roles in intramyocardial inflammation, endothelial dysfunction and oxidative stress in diabetic cardiomyopathy
Title: Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein 1-related peptidase B3

Names: PS kallikrein; gamma-NGF; kallikrein 1; kallikrein a4; nerve growth factor gamma chain; nerve growth factor gamma polypeptide; pancreatic kallikrein; true tissue kallikrein

NP_113711.1

EC 3.4.21.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031523.1 → NP_113711.1 kallikrein 1-related peptidase B3 precursor

See identical proteins and their annotated locations for NP_113711.1

Status: PROVISIONAL

Source sequence(s)

M11563

UniProtKB/Swiss-Prot

P00758, Q68G17

UniProtKB/TrEMBL

A0A0G2JSQ7

Related

ENSRNOP00000025831.1, ENSRNOT00000025831.3

Conserved Domains (2) summary

smart00020
Location:28 → 257

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:29 → 260

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...