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ALOX15 arachidonate 15-lipoxygenase [ Homo sapiens (human) ]

Gene ID: 246, updated on 25-Jan-2025

Summary

Official Symbol
ALOX15provided by HGNC
Official Full Name
arachidonate 15-lipoxygenaseprovided by HGNC
Primary source
HGNC:HGNC:433
See related
Ensembl:ENSG00000161905 MIM:152392; AllianceGenome:HGNC:433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LOG15; 12-LOX; 15-LOX; 15-LOX-1
Summary
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Expression
Biased expression in lung (RPKM 5.0), small intestine (RPKM 1.7) and 11 other tissues See more
Orthologs
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Genomic context

See ALOX15 in Genome Data Viewer
Location:
17p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4630919..4641678, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4520655..4531416, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4534214..4544973, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1996 Neighboring gene uncharacterized LOC105371498 Neighboring gene RNA, U6 small nuclear 955, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4534741-4535270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4535271-4535798 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:4541217-4542416 Neighboring gene uncharacterized LOC105371499 Neighboring gene Sharpr-MPRA regulatory region 3058 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:4552879-4553094 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47177/47178 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47179 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47181 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47184 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47187 Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47196 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47199 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47200 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47201 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47204 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47205 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47206 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47207 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11544 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47211 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47214

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Items 1 - 25 of 29
Process Evidence Code Pubs
involved_in apoptotic cell clearance  
involved_in arachidonate metabolic process  
involved_in arachidonate metabolic process PubMed 
involved_in arachidonate metabolic process PubMed 
involved_in bone mineralization  
involved_in cellular response to calcium ion PubMed 
involved_in cellular response to interleukin-13 PubMed 
involved_in fatty acid oxidation  
involved_in hepoxilin biosynthetic process  
involved_in inflammatory response PubMed 
involved_in linoleic acid metabolic process PubMed 
involved_in lipid metabolic process PubMed 
involved_in lipid oxidation  
involved_in lipoxin A4 biosynthetic process  
involved_in lipoxygenase pathway  
involved_in lipoxygenase pathway PubMed 
involved_in lipoxygenase pathway  
involved_in long-chain fatty acid biosynthetic process  
involved_in negative regulation of adaptive immune response  
involved_in ossification  
involved_in phosphatidylethanolamine biosynthetic process  
involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
involved_in positive regulation of actin filament polymerization  
involved_in positive regulation of cell-substrate adhesion PubMed 
involved_in regulation of engulfment of apoptotic cell  
involved_in regulation of inflammatory response PubMed 
involved_in regulation of peroxisome proliferator activated receptor signaling pathway  
involved_in response to endoplasmic reticulum stress  
involved_in wound healing  
Items 1 - 25 of 29
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane PubMed 
is_active_in cytosol  
located_in cytosol PubMed 
located_in cytosol  
located_in cytosol  
located_in lipid droplet PubMed 
located_in membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
polyunsaturated fatty acid lipoxygenase ALOX15
Names
12/15-lipoxygenase
15-LOX type 1
15-lipooxygenase-1
15-lipoxygenase type 1
arachidonate 12-lipoxygenase, leukocyte-type
arachidonate omega-6 lipoxygenase
hepoxilin A3 synthase Alox15
linoleate 13S-lipoxygenase
NP_001131.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001140.5NP_001131.3  polyunsaturated fatty acid lipoxygenase ALOX15

    See identical proteins and their annotated locations for NP_001131.3

    Status: REVIEWED

    Source sequence(s)
    AK312557, BC029032, M23892
    Consensus CDS
    CCDS11049.1
    UniProtKB/Swiss-Prot
    A8K2P4, B7ZA11, P16050, Q8N6R7, Q99657
    UniProtKB/TrEMBL
    B2R6F7
    Related
    ENSP00000293761.3, ENST00000293761.8
    Conserved Domains (2) summary
    cd01753
    Location:2111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:219653
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    4630919..4641678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    4520655..4531416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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