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Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246211, updated on 3-Apr-2024

Summary

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Official Symbol
Hsd3b7provided by RGD
Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7provided by RGD
Primary source
RGD:628727
See related
Ensembl:ENSRNOG00000019080 AllianceGenome:RGD:628727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cca2
Summary
Enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity. Involved in cholesterol catabolic process; liver regeneration; and regulation of cell growth. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 1 and intrahepatic cholestasis. Orthologous to human HSD3B7 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 642.2), Adrenal (RPKM 146.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hsd3b7 in Genome Data Viewer
Location:
1q37
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191842688..191845919)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182412216..182415447)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199248084..199251745)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene SET domain containing 1A, histone lysine methyltransferase Neighboring gene syntaxin 1B Neighboring gene uncharacterized LOC134483916 Neighboring gene syntaxin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation of a novel cDNA whose corresponding mRNA is accumulated in growth-arrested confluent but not in growing sub-confluent rat 3Y1 cells. Hayashi Y, et al. Biochim Biophys Acta, 1997 May 30. PMID 9199244
  2. Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats. Maeda Y, et al. Ann Clin Lab Sci, 2005 Summer. PMID 16081591
  3. Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease. Cheng JB, et al. J Clin Endocrinol Metab, 2003 Apr. PMID 12679481
  4. The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. Schwarz M, et al. J Clin Invest, 2000 Nov. PMID 11067870, Free PMC Article
  5. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Yi T, et al. Immunity, 2012 Sep 21. PMID 22999953, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that the mechanisms of regulation of these bile acid metabolizing enzymes are significantly different during liver regeneration
    Title: Bile acid biosynthesis during liver regeneration: enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in B cell chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in B cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in bile acid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in cholesterol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3 beta-hydroxysteroid dehydrogenase type 7
Names
3 beta-hydroxysteroid dehydrogenase type VII
3-beta-HSD VII
3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase
c(27) 3-beta-HSD
cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase
confluent 3Y1 cell-associated 2
NP_001385604.1
NP_647545.2
XP_038955467.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398675.1 → NP_001385604.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6APT0, A6I9U5
    Related
    ENSRNOP00000091092.1, ENSRNOT00000097840.1
    Conserved Domains (1) summary
    cl21454
    Location:11 → 361
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_139329.3 → NP_647545.2  3 beta-hydroxysteroid dehydrogenase type 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    O35048
    UniProtKB/TrEMBL
    A6I9U6
    Conserved Domains (1) summary
    cl21454
    Location:11 → 330
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    191842688..191845919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099539.2 → XP_038955467.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform X1

    UniProtKB/Swiss-Prot
    O35048
    Conserved Domains (1) summary
    cl21454
    Location:11 → 317
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35048.1 GenPept UniProtKB/Swiss-Prot:O35048

Gene LinkOut

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