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Zfp180 zinc finger protein 180 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246279, updated on 13-Apr-2024

Summary

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Official Symbol
Zfp180provided by RGD
Official Full Name
zinc finger protein 180provided by RGD
Primary source
RGD:631380
See related
Ensembl:ENSRNOG00000029336 AllianceGenome:RGD:631380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rKr1
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Orthologous to human ZNF180 (zinc finger protein 180). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 151.1), Muscle (RPKM 98.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp180 in Genome Data Viewer
Location:
1q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88780342..88800637)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (79652441..79672737)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80920745..80940038)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily, member 23 Neighboring gene CEA cell adhesion molecule 20 Neighboring gene SUB1 regulator of transcription, pseudogene 1 Neighboring gene thymosin beta-4-like Neighboring gene zinc finger protein 112 Neighboring gene zinc finger protein 235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A new Cys2/His2 zinc finger gene, rKr1, expressed in oligodendrocytes and neurons. Pott U, et al. Brain Res Mol Brain Res, 1996 May. PMID 8737674
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 180
Names
Cys2/His2 zinc finger protein (rKr1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271280.1 → NP_001258209.1  zinc finger protein 180 isoform 2

    See identical proteins and their annotated locations for NP_001258209.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6J8W2, A6J8W3, Q62886
    Related
    ENSRNOP00000026077.2, ENSRNOT00000026077.5
    Conserved Domains (4) summary
    COG5048
    Location:292 → 646
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:483 → 503
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:313 → 335
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:523 → 548
    zf-H2C2_2; Zinc-finger double domain

  2. NM_144757.3 → NP_653358.2  zinc finger protein 180 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000001
    Conserved Domains (3) summary
    COG5048
    Location:395 → 657
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:560 → 580
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:685 → 709
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    88780342..88800637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228387.5 → XP_006228449.1  zinc finger protein 180 isoform X1

    See identical proteins and their annotated locations for XP_006228449.1

    UniProtKB/TrEMBL
    A6J8W2, A6J8W3, Q62886
    Related
    ENSRNOP00000082065.1
    Conserved Domains (4) summary
    COG5048
    Location:292 → 646
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:483 → 503
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:313 → 335
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:523 → 548
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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