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Lgi2 leucine-rich repeat LGI family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 246316, updated on 8-May-2024

Summary

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Official Symbol
Lgi2provided by MGI
Official Full Name
leucine-rich repeat LGI family, member 2provided by MGI
Primary source
MGI:MGI:2180196
See related
Ensembl:ENSMUSG00000039252 AllianceGenome:MGI:2180196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1916
Summary
Involved in inhibitory synapse assembly. Located in extracellular space. Is expressed in alimentary system; central nervous system; nose; and orbito-sphenoid. Orthologous to human LGI2 (leucine rich repeat LGI family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 13.1), cortex adult (RPKM 6.4) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Lgi2 in Genome Data Viewer
Location:
5 C1; 5 28.25 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (52690859..52723689, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (52533517..52566306, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene superoxide dismutase 3, extracellular Neighboring gene coiled-coil domain containing 149 Neighboring gene predicted gene 3519 Neighboring gene STARR-seq mESC enhancer starr_13063 Neighboring gene STARR-seq mESC enhancer starr_13064 Neighboring gene predicted gene 5866 Neighboring gene RIKEN cDNA 8030423F21 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy. Senechal KR, et al. Hum Mol Genet, 2005 Jun 15. PMID 15857855
  2. LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period. Kozar-Gillan N, et al. J Cell Biol, 2023 Apr 3. PMID 36828548, Free PMC Article
  3. Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain. Herranz-Pérez V, et al. Brain Res, 2010 Jan 11. PMID 19833108
  4. The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders. Staub E, et al. Trends Biochem Sci, 2002 Sep. PMID 12217514
  5. Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits. Favuzzi E, et al. Science, 2019 Jan 25. PMID 30679375

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in inhibitory synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inhibitory synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space HDA PubMed 

General protein information

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Preferred Names
leucine-rich repeat LGI family member 2
Names
leucine-rich glioma-inactivated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310604.1 → NP_001297533.1  leucine-rich repeat LGI family member 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001297533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon and uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC120128, AI843865, AJ487515, CJ124394
    Consensus CDS
    CCDS80281.1
    UniProtKB/TrEMBL
    Q50DZ7
    Related
    ENSMUSP00000143707.2, ENSMUST00000199942.5
    Conserved Domains (5) summary
    sd00031
    Location:108 → 131
    LRR_1; leucine-rich repeat [structural motif]
    pfam03736
    Location:216 → 257
    EPTP; EPTP domain
    pfam12799
    Location:107 → 146
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:107 → 166
    LRR_8; Leucine rich repeat
    cl15307
    Location:164 → 198
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  2. NM_144945.3 → NP_659194.1  leucine-rich repeat LGI family member 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_659194.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encode the longer isoform (1).
    Source sequence(s)
    AC120128, AI843865, AJ487515
    Consensus CDS
    CCDS19285.1
    UniProtKB/Swiss-Prot
    Q80T76, Q8K4Z0
    Related
    ENSMUSP00000040436.6, ENSMUST00000039750.7
    Conserved Domains (6) summary
    sd00031
    Location:108 → 131
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:63 → 83
    LRR_RI; leucine-rich repeat [structural motif]
    pfam03736
    Location:224 → 265
    EPTP; EPTP domain
    pfam12799
    Location:107 → 143
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:94 → 142
    LRR_8; Leucine rich repeat
    cl15307
    Location:140 → 174
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    52690859..52723689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503965.4 → XP_006504028.1  leucine-rich repeat LGI family member 2 isoform X1

    UniProtKB/TrEMBL
    Q8BYS1
    Conserved Domains (1) summary
    pfam03736
    Location:48 → 87
    EPTP; EPTP domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4Z0.1 GenPept UniProtKB/Swiss-Prot:Q8K4Z0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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